Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND

HIV-1 Tat Length: Comparative and Functional Considerations

(2020) Anthony R. Mele et al.   Frontiers in Microbiology

Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

(2019) Huaqian Dong et al.   Frontiers in Neuroscience

Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

(2019) Sonia Mediouni et al.   mBio

Genetic variation and function of the HIV-1 Tat protein

(2019) Cassandra Spector et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND

(2019) Bianca Cotto et al.   JOURNAL OF NEUROVIROLOGY

Effects of HIV ‐1 Tat on oligodendrocyte viability are mediated by Ca MKII β– GSK 3β interactions

(2019) Shiping Zou et al.   JOURNAL OF NEUROCHEMISTRY

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis

(2019) Palsamy Periyasamy et al.   BRAIN BEHAVIOR AND IMMUNITY

Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression

(2019) Ying Liu et al.   JOURNAL OF NEUROVIROLOGY

Role of Cav-1 in HIV-1 Tat-Induced Dysfunction of Tight Junctions and Aβ-Transferring Proteins

(2019) Min Zou et al.   Oxidative Medicine and Cellular Longevity

HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture

(2019) Guoku Hu et al.   Journal of Neuroimmune Pharmacology

Investigating the distribution of HIV-1 Tat lengths present in the Drexel Medicine CARES cohort

(2019) Robert W. Link et al.   VIRUS RESEARCH

Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy

(2019) Lisa J. Henderson et al.   AIDS

Signatures of HIV-1 subtype B and C Tat proteins and their effects in the neuropathogenesis of HIV-associated neurocognitive impairments

(2019) Monray E. Williams et al.   NEUROBIOLOGY OF DISEASE

HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy

(2018) Annadurai Thangaraj et al.   Autophagy

HIV-1 Protein Tat1–72 Impairs Neuronal Dendrites via Activation of PP1 and Regulation of the CREB/BDNF Pathway

(2018) Yu Liu et al.   VIROLOGICA SINICA

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-Tat regulates macrophage gene expression in the context of neuroAIDS

(2017) Loreto Carvallo et al.   PLoS One

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

(2017) Evan Clark et al.   Oncotarget

Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes

(2017) Gi Soo Youn et al.   Redox Biology

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

(2017) Alex M. Dickens et al.   Scientific Reports

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

HIV-1 Tat Inhibits Autotaxin Lysophospholipase D Activity and Modulates Oligodendrocyte Differentiation

(2016) Natalie A. Wheeler et al.   ASN Neuro

HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

(2016) Joan W. Berman et al.   Journal of Neuroinflammation

HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells

(2016) Roberta Mastrantonio et al.   PLoS One

The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes

(2016) Luca Sardo et al.   Retrovirology

Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications

(2016) Guoku Hu et al.   Cell Death & Disease

Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis

(2016) Massimiliano Di Filippo et al.   Scientific Reports

Interactions of innate and adaptive immunity in brain development and function

(2015) Anthony J. Filiano et al.   BRAIN RESEARCH

STAT3 and Its Phosphorylation are Involved in HIV-1 Tat-Induced Transactivation of Glial Fibrillary Acidic Protein

(2015) Yan Fan et al.   CURRENT HIV RESEARCH

Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice

(2015) Sonia Mediouni et al.   CURRENT HIV RESEARCH

Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development

(2015) S. Zou et al.   JOURNAL OF NEUROSCIENCE

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

(2015) Katherine Luzuriaga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update

(2015) Venkata Subba Rao Atluri et al.   Frontiers in Cellular Neuroscience

The Potential of the CNS as a Reservoir for HIV-1 Infection: Implications for HIV Eradication

(2015) Alessandro F. Fois et al.   Current HIV/AIDS Reports

Transcriptional Profile of HIV-induced Nuclear Translocation of Amyloid β in Brain Endothelial Cells

(2014) Ibolya E. András et al.   ARCHIVES OF MEDICAL RESEARCH

Cytokine secretion from brain macrophages infected with human immunodeficiency virus in vitro and treated with raltegravir

(2014) Erick T Tatro et al.   BMC INFECTIOUS DISEASES

HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability

(2014) Ritu Mishra et al.   BMC NEUROSCIENCE

HIV Tat protein affects circadian rhythmicity by interfering with the circadian system

(2014) T Wang et al.   HIV MEDICINE

Differential Effects of Tat Proteins Derived from HIV-1 Subtypes B and Recombinant CRF02_AG on Human Brain Microvascular Endothelial Cells: Implications for Blood–Brain Barrier Dysfunction

(2014) Shawna M Woollard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes mediate HIV-1 Tat-induced neuronal damage via ligand-gated ion channel P2X7R

(2014) Manju Tewari et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes

(2014) Anantha Ram Nookala et al.   Journal of Neuroinflammation

HIV-1 target cells in the CNS

(2014) Sarah B. Joseph et al.   JOURNAL OF NEUROVIROLOGY

HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

(2014) Rong Ma et al.   MOLECULAR NEUROBIOLOGY

Is the central nervous system a reservoir of HIV-1?

(2014) Lachlan R. Gray et al.   Current Opinion in HIV and AIDS

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity

(2013) Caterina Capone et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+T Lymphocytes

(2013) María Rosa López-Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term Reduction in Peripheral Blood HIV Type 1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation

(2013) T. J. Henrich et al.   JOURNAL OF INFECTIOUS DISEASES

Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival

(2013) Adriano Ferrucci et al.   JOURNAL OF NEUROVIROLOGY

NMDA receptors in nervous system diseases

(2013) Qiang Zhou et al.   NEUROPHARMACOLOGY

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

(2013) Kunal Gupta et al.   NEUROSCIENCE LETTERS

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

(2013) Deborah Persaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways

(2013) Anantha R. Nookala et al.   PLoS One

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

(2012) Sylvia Fitting et al.   BIOLOGICAL PSYCHIATRY

Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier

(2012) Shinsuke Nakagawa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

(2012) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human Immunodeficiency Virus Type 1 (HIV-1) Transactivator of Transcription through Its Intact Core and Cysteine-Rich Domains Inhibits Wnt/ -Catenin Signaling in Astrocytes: Relevance to HIV Neuropathogenesis

(2012) L. J. Henderson et al.   JOURNAL OF NEUROSCIENCE

HIV-1 Tat Triggers Nuclear Localization of ZO-1 via Rho Signaling and cAMP Response Element-Binding Protein Activation

(2012) Y. Zhong et al.   JOURNAL OF NEUROSCIENCE

Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures

(2012) Angela H. Shin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir

(2012) Adriano Ferrucci et al.   VIRUS RESEARCH

Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at  -opioid receptor-expressing glia

(2011) S. Zou et al.   BRAIN

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

(2011) Ruifen Xu et al.   BRAIN RESEARCH

Toll-like Receptor Expression and Activation in Astroglia: Differential Regulation by HIV-1 Tat, gp120, and Morphine

(2011) Nazira El-Hage et al.   IMMUNOLOGICAL INVESTIGATIONS

HIV-1 Tat-Mediated Induction of Platelet-Derived Growth Factor in Astrocytes: Role of Early Growth Response Gene 1

(2011) Crystal Bethel-Brown et al.   JOURNAL OF IMMUNOLOGY

Methamphetamine and HIV-1 Tat Down Regulate β-catenin Signaling: Implications for Methampetamine Abuse and HIV-1 Co-morbidity

(2011) Amit Sharma et al.   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression

(2011) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Host factors mediating HIV-1 replication

(2011) Brian M. Friedrich et al.   VIRUS RESEARCH

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

(2010) Samanta Simioni et al.   AIDS

Activation of Egr-1 Expression in Astrocytes by HIV-1 Tat: New Insights into Astrocyte-Mediated Tat Neurotoxicity

(2010) Yan Fan et al.   Journal of Neuroimmune Pharmacology

Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: Implications for HIV-1–associated neurocognitive disorder

(2010) Nimisha Gandhi et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine–glutamate antiporter

(2010) Sunita Gupta et al.   NEUROSCIENCE LETTERS

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: microbial interactions in HIV infection

(2009) Howard CH Yim et al.   AIDS

HIV Subtype D Is Associated with Dementia, Compared with Subtype A, in Immunosuppressed Individuals at Risk of Cognitive Impairment in Kampala, Uganda

(2009) Ned Sacktor et al.   CLINICAL INFECTIOUS DISEASES

Nef and cell signaling transduction: a possible involvement in the pathogenesis of human immunodeficiency virus–associated dementia

(2009) Valeria Bergonzini et al.   JOURNAL OF NEUROVIROLOGY

Acquired immunodeficiency syndrome and the blood-brain barrier

(2009) Nathan S Ivey et al.   JOURNAL OF NEUROVIROLOGY

The biology of CCR5 and CXCR4

(2009) Ghalib Alkhatib   Current Opinion in HIV and AIDS

NADPH Oxidase Drives Cytokine and Neurotoxin Release from Microglia and Macrophages in Response to HIV-Tat

(2008) Jadwiga Turchan–Cholewo et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily

(2008) Jae J. Song et al.   CELLULAR SIGNALLING

HIV-1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology

(2008) Kurt F. Hauser et al.   GLIA

Tight Junction Regulation by Morphine and HIV-1 Tat Modulates Blood–Brain Barrier Permeability

(2008) Supriya D. Mahajan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CCL5/RANTES Gene Deletion Attenuates Opioid-Induced Increases in Glial CCL2/MCP-1 Immunoreactivity and Activation in HIV-1 Tat-Exposed Mice

(2008) Nazira El-Hage et al.   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death

(2008) H. J. Kim et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Activation by HIV-Tat Protein Is Clade Dependent

(2008) W. Li et al.   JOURNAL OF NEUROSCIENCE

HIV-1 Clade-Specific Differences in the Induction of Neuropathogenesis

(2008) V. R. Rao et al.   JOURNAL OF NEUROSCIENCE

Caveolin-1 Regulates Human Immunodeficiency Virus-1 Tat-Induced Alterations of Tight Junction Protein Expression via Modulation of the Ras Signaling

(2008) Y. Zhong et al.   JOURNAL OF NEUROSCIENCE

Human immunodeficiency virus type 1 gp120–mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells

(2008) Shinichi Nakamuta et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

(2008) John P. Norman et al.   PLoS One

Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

(2007) Mamata Mishra et al.   ANNALS OF NEUROLOGY

Human immunodeficiency virus type-1 Tat protein induces nuclear factor (NF)-κB activation and oxidative stress in microglial cultures by independent mechanisms

(2003) Alessia Nicolini et al.   JOURNAL OF NEUROCHEMISTRY