Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

(2016) Alexandre J. C. Quaresma et al.   NUCLEIC ACIDS RESEARCH

Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region

(2016) Xuechao Zhao et al.   VIROLOGICA SINICA

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders

(2015) Sonia Mediouni et al.   Frontiers in Microbiology

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

(2015) Eline Boons et al.   EBioMedicine

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4

(2014) Jianyou Gu et al.   CELL CYCLE

Characterization of the Influence of Mediator Complex in HIV-1 Transcription

(2014) Alba Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter

(2014) Hye-Young Kim et al.   Retrovirology

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

(2013) Huasong Lu et al.   CHEMICAL REVIEWS

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Identification of a Highly Conserved Surface on Tat Variants

(2013) Sonia Mediouni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

A Monoclonal Antibody Directed against a Conformational Epitope of the HIV-1 Trans-activator (Tat) Protein Neutralizes Cross-clade

(2012) Sonia Mediouni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein

(2012) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

(2012) D. C. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function and regulation of the Mediator complex

(2011) Ronald C Conaway et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Synthetic studies toward (+)-cortistatin A

(2011) Zhang Wang et al.   TETRAHEDRON

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

(2010) Lisa Muniz et al.   PLoS Pathogens

HIV-1 Tat is unconventionally secreted through the plasma membrane

(2009) Fabienne Rayne et al.   CELL BIOLOGY INTERNATIONAL

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

High yield expression and purification of HIV-1 Tat1−72 for structural studies

(2009) Shaheen Shojania et al.   JOURNAL OF VIROLOGICAL METHODS

Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat

(2009) H. Sivakumaran et al.   JOURNAL OF VIROLOGY

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

(2009) Grant R Campbell et al.   Retrovirology

Short Communication: Cataloguing the HIV Type 1 Human Protein Interaction Network

(2008) Roger G. Ptak et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Binding sites of the viral RNA element TAR and of TAR mutants for various peptide ligands, probed with LILBID: A new laser mass spectrometry

(2008) Nina Morgner et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Role of Cellular RNA Processing Factors in Human Immunodeficiency Virus Type 1 mRNA Metabolism, Replication, and Infectivity

(2008) J. A. Jablonski et al.   JOURNAL OF VIROLOGY

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

(2008) Rachel Van Duyne et al.   Retrovirology