Genetic variation and function of the HIV-1 Tat protein

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

(2018) Andrey Ivanov et al.   Retrovirology

Defining the molecular mechanisms of HIV-1 Tat secretion: PtdIns(4,5)P2 at the epicenter

(2018) Anthony R Mele et al.   TRAFFIC

The evolution of subtype B HIV-1 tat in the Netherlands during 1985–2012

(2018) Antoinette C. van der Kuyl et al.   VIRUS RESEARCH

Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression

(2017) Philippe Selhorst et al.   JOURNAL OF VIROLOGY

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-Tat regulates macrophage gene expression in the context of neuroAIDS

(2017) Loreto Carvallo et al.   PLoS One

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations

(2017) Doreen Kamori et al.   Frontiers in Microbiology

PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription

(2017) Tyler B. Faust et al.   Scientific Reports

Structural Basis for Importin-α Binding of the Human Immunodeficiency Virus Tat

(2017) K. M. Smith et al.   Scientific Reports

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

(2016) Alex J. Fulcher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HIV-associated neurocognitive disorder

(2016) David B. Clifford   CURRENT OPINION IN INFECTIOUS DISEASES

Novel strategies for Alzheimer's disease treatment: An overview of anti-amyloid beta monoclonal antibodies

(2016) Katarzyna Rygiel   INDIAN JOURNAL OF PHARMACOLOGY

The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7

(2016) Ibraheem Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the roles for Vpr in HIV-1-associated neuropathogenesis

(2016) Tony James et al.   JOURNAL OF NEUROVIROLOGY

Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status

(2016) Will Dampier et al.   JOURNAL OF NEUROVIROLOGY

A Test in Context: Neprilysin

(2016) Antoni Bayes-Genis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Utilization of HIV-1 envelope V3 to identify X4- and R5-specific Tat and LTR sequence signatures

(2016) Gregory C. Antell et al.   Retrovirology

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease

(2016) Monique E. Maubert et al.   Frontiers in Microbiology

HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients

(2016) Will Dampier et al.   PLoS One

Viral Evolved Inhibition Mechanism of the RNA Dependent Protein Kinase PKR's Kinase Domain, a Structural Perspective

(2016) K. Hari Krishna et al.   PLoS One

Intersubtype Genetic Variation of HIV-1 Tat Exon 1

(2015) Chandra Nath Roy et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Tat protein: Is Tat-C much trickier than Tat-B?

(2015) Manish Kumar Johri et al.   JOURNAL OF MEDICAL VIROLOGY

p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation

(2015) Cheol-Hee Yoon et al.   JOURNAL OF VIROLOGY

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

Evolutionary Dynamics of Tat in HIV-1 Subtypes B and C

(2015) Chandra Nath Roy et al.   PLoS One

High variability of genomic instability and gene expression profiling in different HeLa clones

(2015) Annalisa Frattini et al.   Scientific Reports

Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4

(2014) Jianyou Gu et al.   CELL CYCLE

Tat-Induced FOXO3a Is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T Lymphocytes

(2014) A. Dabrowska et al.   JOURNAL OF IMMUNOLOGY

Impact of the HIV Tat C30C31S dicysteine substitution on neuropsychological function in patients with clade C disease

(2014) Robert H. Paul et al.   JOURNAL OF NEUROVIROLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Defining Differential Genetic Signatures in CXCR4- and the CCR5-Utilizing HIV-1 Co-Linear Sequences

(2014) Benjamas Aiamkitsumrit et al.   PLoS One

Human immunodeficiency virus Tat associates with a specific set of cellular RNAs

(2014) Russell D Bouwman et al.   Retrovirology

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells

(2014) Sami Kukkonen et al.   Retrovirology

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I

(2014) Sonia Shah et al.   Virology Journal

HIV-1 Tat protein variants: Critical role for the cysteine region in synaptodendritic injury

(2013) Sarah J. Bertrand et al.   EXPERIMENTAL NEUROLOGY

The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+T Lymphocytes

(2013) María Rosa López-Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders

(2013) William Tyor et al.   JOURNAL OF NEUROVIROLOGY

tat Exon 1 Exhibits Functional Diversity during HIV-1 Subtype C Primary Infection

(2013) R. Rossenkhan et al.   JOURNAL OF VIROLOGY

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity

(2013) Minghao He et al.   PLoS One

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein

(2013) Jiyoung Kim et al.   PLoS One

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

The Genomic and Transcriptomic Landscape of a HeLa Cell Line

(2013) Jonathan J. M. Landry et al.   G3-Genes Genomes Genetics

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Sialic Acid Associated with αvβ3Integrin Mediates HIV-1 Tat Protein Interaction and Endothelial Cell Proangiogenic Activation

(2012) Paola Chiodelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development

(2012) S. Dahiya et al.   JOURNAL OF GENERAL VIROLOGY

Transition Step during Assembly of HIV Tat:P-TEFb Transcription Complexes and Transfer to TAR RNA

(2012) I. D'Orso et al.   MOLECULAR AND CELLULAR BIOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus

(2012) Mohamed Ali Jarboui et al.   PLoS One

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression

(2011) S. Tyagi et al.   JOURNAL OF GENERAL VIROLOGY

HIV-1 Infection Induces Acetylation of NPM1 That Facilitates Tat Localization and Enhances Viral Transactivation

(2011) Shrikanth S. Gadad et al.   JOURNAL OF MOLECULAR BIOLOGY

Development of co-selected single nucleotide polymorphisms in the viral promoter precedes the onset of human immunodeficiency virus type 1-associated neurocognitive impairment

(2011) Luna Li et al.   JOURNAL OF NEUROVIROLOGY

The HIV-1 Tat Protein Has a Versatile Role in Activating Viral Transcription

(2011) A. T. Das et al.   JOURNAL OF VIROLOGY

HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes

(2011) Lokesh Agrawal et al.   NEUROBIOLOGY OF DISEASE

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

(2010) Samanta Simioni et al.   AIDS

The Cellular Lysine Methyltransferase Set7/9-KMT7 Binds HIV-1 TAR RNA, Monomethylates the Viral Transactivator Tat, and Enhances HIV Transcription

(2010) Sara Pagans et al.   Cell Host & Microbe

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia

(2010) Daniel Cowley et al.   JOURNAL OF NEUROVIROLOGY

Effect of the redox state on HIV-1 tat protein multimerization and cell internalization and trafficking

(2010) Raffaella Pierleoni et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures

(2010) M.Y. Aksenov et al.   NEUROSCIENCE LETTERS

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon

(2010) M. R. Lopez-Huertas et al.   NUCLEIC ACIDS RESEARCH

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription

(2010) Liling Tang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage

(2010) Evelyn M Kilareski et al.   Retrovirology

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

Functional analysis of HIV-1 subtypes B and C HIV-1 Tat exons and RGD/QGD motifs with respect to Tat-mediated transactivation and apoptosis

(2009) Vikas Sood et al.   AIDS

Differential Effects of HIV Type 1 Clade B and Clade C Tat Protein on Expression of Proinflammatory and Antiinflammatory Cytokines by Primary Monocytes

(2009) Nimisha Gandhi et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures

(2009) Michael Y. Aksenov et al.   EXPERIMENTAL NEUROLOGY

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Clade B Tat, but Not Clade C Tat, Increases X4 HIV-1 Entry into Resting but Not Activated CD4+T Cells

(2009) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex

(2009) I. D'Orso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects

(2009) Filippo Canducci et al.   Retrovirology

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

(2009) Grant R Campbell et al.   Retrovirology

The HIV Tat protein affects processing of ribosomal RNA precursor

(2008) Donatella Ponti et al.   BMC CELL BIOLOGY

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

(2008) Hye-Sook Kwon et al.   Cell Host & Microbe

NMDA Receptor Activation by HIV-Tat Protein Is Clade Dependent

(2008) W. Li et al.   JOURNAL OF NEUROSCIENCE

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

(2008) Pradeep D. Uchil et al.   PLoS Pathogens

Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat

(2008) Caroline Egelé et al.   Retrovirology

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

(2008) Rachel Van Duyne et al.   Retrovirology

Tuning the Transport Properties of HIV-1 Tat Arginine-Rich Motif in Living Cells

(2008) Francesco Cardarelli et al.   TRAFFIC

Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

(2007) Mamata Mishra et al.   ANNALS OF NEUROLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY