The Double-Faced Role of Nitric Oxide and Reactive Oxygen Species in Solid Tumors

Effect of the Nrf2‑ARE signaling pathway on biological characteristics and sensitivity to sunitinib in renal cell carcinoma

(2019) Shiliang Ji et al.   Oncology Letters

Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo

(2019) Svetlana Paskas et al.   INVESTIGATIONAL NEW DRUGS

Senescence as a main mechanism of Ritonavir and Ritonavir‐NO action against melanoma

(2019) Svetlana Paskaš et al.   MOLECULAR CARCINOGENESIS

Chemotherapy in Combination With Immune Checkpoint Inhibitors for the First-Line Treatment of Patients With Advanced Non-small Cell Lung Cancer: A Systematic Review and Literature-Based Meta-Analysis

(2019) Alfredo Addeo et al.   Frontiers in Oncology

S-nitrosylation and its role in breast cancer angiogenesis and metastasis

(2019) Pamela Ehrenfeld et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Prognostic Value of Inducible Nitric Oxide Synthase (iNOS) in Human Cancer: A Systematic Review and Meta-Analysis

(2019) Wenbiao Liao et al.   Biomed Research International

Reactive Oxygen Species in the Tumor Microenvironment: An Overview

(2019) Frank Weinberg et al.   Cancers

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

(2018) Luksana Chaiswing et al.   ANTIOXIDANTS & REDOX SIGNALING

Naturally occurring compounds in differentiation based therapy of cancer

(2018) Sanja Mijatović et al.   BIOTECHNOLOGY ADVANCES

New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations

(2018) Elisabetta Bigagli et al.   INVESTIGATIONAL NEW DRUGS

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

(2018) Rom Keshet et al.   Disease Models & Mechanisms

Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells

(2018) Maria Basile et al.   MOLECULES

Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy

(2018) Thibault Le Bourgeois et al.   Frontiers in Oncology

Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors

(2018) Marija Pljesa-Ercegovac et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron in the Tumor Microenvironment—Connecting the Dots

(2018) Christa Pfeifhofer-Obermair et al.   Frontiers in Oncology

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype

(2017) Stefan Rodic et al.   INTERNATIONAL JOURNAL OF CANCER

HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?

(2017) Danijela Maksimovic-Ivanic et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma

(2017) Ali Mehdi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib

(2017) Lixia Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

(2017) Hanna-Riikka Teppo et al.   Oxidative Medicine and Cellular Longevity

Upregulated glutathione transferase omega-1 correlates with progression of urinary bladder carcinoma

(2017) Tatjana Djukic et al.   REDOX REPORT

Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells

(2017) Daniel Bauer et al.   Cell Death & Disease

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

(2017) Nancy D. Ebelt et al.   Oncotarget

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

(2017) Elsa B Krall et al.   eLife

Nitric Oxide Accumulation: The Evolutionary Trigger for Phytopathogenesis

(2017) Margarida M. Santana et al.   Frontiers in Microbiology

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress

(2016) Hesham M. Korashy et al.   TOXICOLOGY LETTERS

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Erlotinib induces the human non-small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways

(2016) Fenglian Shan et al.   Cancer Medicine

NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells

(2016) Pengying Li et al.   Redox Biology

The Redox Code

(2015) Dean P. Jones et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity

(2015) Wenwen Duan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma

(2015) Yang Yuan et al.   BMC CANCER

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Reactive nitrogen species in cellular signaling

(2015) Levi Adams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Gefitinib-mediated Reactive Oxygen Specie (ROS) Instigates Mitochondrial Dysfunction and Drug Resistance in Lung Cancer Cells

(2015) Imoh S. Okon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired endothelium-dependent vasodilation does not initiate the development of sunitinib-associated hypertension

(2015) Anna M.J. Thijs et al.   JOURNAL OF HYPERTENSION

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer

(2015) Sandra M. Swain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction

(2015) Akram Sadeghirizi et al.   TUMOR BIOLOGY

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells

(2015) Maria Beatrice Morelli et al.   Oncotarget

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

(2015) Valentina Tesori et al.   Scientific Reports

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

(2015) Edward L. LaGory et al.   Cell Reports

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics

(2015) Benjamin Bonavida et al.   Redox Biology

The dual role of iNOS in cancer

(2015) Federica Vannini et al.   Redox Biology

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

(2015) Ryuta Tobe et al.   Cancers

Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon

(2015) Cristina Branco-Price et al.   Oncotarget

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nitric Oxide Mediates Metabolic Coupling of Omentum-Derived Adipose Stroma to Ovarian and Endometrial Cancer Cells

(2014) B. Salimian Rizi et al.   CANCER RESEARCH

Mechanisms of Hypoxia-Mediated Immune Escape in Cancer

(2014) I. B. Barsoum et al.   CANCER RESEARCH

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction

(2014) Wei Cui et al.   CNS Neuroscience & Therapeutics

Involvement of superoxide and nitric oxide in BRAFV600E inhibitor PLX4032-induced growth inhibition of melanoma cells

(2014) Ling Yu et al.   Integrative Biology

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Extracellular iron diminishes anticancer effects of vitamin C: An in vitro study

(2014) Marija Mojić et al.   Scientific Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Does Scavenging of Mitochondrial Superoxide Attenuate Cancer Prosurvival Signaling Pathways?

(2013) Rafal R. Nazarewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

(2013) S. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

(2013) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL

(2012) Marija Mojic et al.   CELL CYCLE

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

(2012) Natalie E. Simpson et al.   Epigenetics

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production In Vitro and In Vivo

(2012) R. Coriat et al.   MOLECULAR CANCER THERAPEUTICS

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells

(2012) MARCO DONIA et al.   ONCOLOGY REPORTS

Epithelial transforming growth factor  -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

(2012) E. Omori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer

(2012) Thuy Vu et al.   Frontiers in Oncology

S-Nitrosoglutathione Reductase in Human Lung Cancer

(2011) Nadzeya V. Marozkina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells

(2011) Katherine M. Aird et al.   BREAST CANCER RESEARCH AND TREATMENT

Erlotinib-Mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4

(2011) K. P. Orcutt et al.   CANCER RESEARCH

In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells

(2011) Marco Donia et al.   CELL CYCLE

Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration

(2011) Aristidis S. Veskoukis et al.   CELL STRESS & CHAPERONES

Immunotherapy for Renal Cell Carcinoma

(2011) Momoe Itsumi et al.   Clinical & Developmental Immunology

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

Redox signaling at invasive microdomains in cancer cells

(2011) Begoña Díaz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells

(2011) Shao-Ping Chang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic

(2011) Chang-Lin Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

DNA methylation in cancer development, diagnosis and therapy--multiple opportunities for genotoxic agents to act as methylome disruptors or remediators

(2011) J. Lewandowska et al.   MUTAGENESIS

Stressed tumor cell, chemosensitized cancer

(2011) Erik A C Wiemer   NATURE MEDICINE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant hep G2 cells through a mitochondria-dependent oxidative stress mechanism

(2010) Jeng-Fong Chiou et al.   CANCER BIOLOGY & THERAPY

Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals

(2010) Ghada M. Suddek   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO

(2010) Sanja Mijatovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytotoxic and immune-sensitizing properties of nitric oxide-modified saquinavir in iNOS-positive human melanoma cells

(2010) Sanja Mijatovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Prognostic Significance of Vascular Endothelial Growth Factor in Squamous Cell Carcinomas of the Tonsil in Relation to Human Papillomavirus Status and Epidermal Growth Factor Receptor

(2009) Jimin Fei et al.   ANNALS OF SURGICAL ONCOLOGY

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

(2009) H. Pelicano et al.   CANCER RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Nitrite as regulator of hypoxic signaling in mammalian physiology

(2009) Ernst E. van Faassen et al.   MEDICINAL RESEARCH REVIEWS

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt

(2009) D. Maksimovic-Ivanic et al.   MOLECULAR CANCER THERAPEUTICS

Glutathione S-transferases in kidney and urinary bladder tumors

(2009) Tatjana Simic et al.   Nature Reviews Urology

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

ERLOTINIB ACTIVATES MITOCHONDRIAL DEATH PATHWAYS RELATED TO THE PRODUCTION OF REACTIVE OXYGEN SPECIES IN THE HUMAN NON-SMALL CELL LUNG CANCER CELL LINE A549

(2008) Xia Qian et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo

(2008) D. Maksimovic-Ivanic et al.   MOLECULAR CANCER THERAPEUTICS

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid–nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells

(2008) Sanja Mijatovic et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE