DNA methylation in cancer development, diagnosis and therapy--multiple opportunities for genotoxic agents to act as methylome disruptors or remediators

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

(2010) Christian Popp et al.   NATURE

Quantitative comparison of genome-wide DNA methylation mapping technologies

(2010) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Epigenome: mapping in motion

(2010) Monya Baker   NATURE METHODS

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution

(2010) Hongcang Gu et al.   NATURE METHODS

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease

(2009) R Mayor et al.   BRITISH JOURNAL OF CANCER

Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

(2009) N Steele et al.   BRITISH JOURNAL OF CANCER

The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer

(2009) R Shah et al.   BRITISH JOURNAL OF CANCER

DNA hypomethylation in the origin and pathogenesis of human diseases

(2009) Igor P. Pogribny et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Methylation at the C-5 Position of Cytosine by Methyl Radicals: A Possible Role for Epigenetic Change during Carcinogenesis by Environmental Agents

(2009) Hiroshi Kasai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer

(2009) T. deVos et al.   CLINICAL CHEMISTRY

Global and gene-specific promoter methylation changes are related toanti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals

(2009) Sofia Pavanello et al.   INTERNATIONAL JOURNAL OF CANCER

Determination of 5-methyl-2′-deoxycytidine in genomic DNA using high performance liquid chromatography-ultraviolet detection

(2009) Jatinderpal Sandhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Methods for genome-wide analysis of DNA methylation in intestinal tumors

(2009) Maria A. Hahn et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

(2009) Nidhi Bhutani et al.   NATURE

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine

(2009) Wen-bin Liu et al.   TOXICOLOGY LETTERS

Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors

(2008) T. Vaissiere et al.   CANCER RESEARCH

Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene

(2008) Tetyana V. Bagnyukova et al.   CARCINOGENESIS

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

Use of DNA methylation for cancer detection: Promises and challenges

(2008) Jingde Zhu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas

(2008) Jolanta Guz et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The bisulfite genomic sequencing used in the analysis of epigenetic states, a technique in the emerging environmental genotoxicology research

(2008) H HAYATSU   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cyclical DNA methylation of a transcriptionally active promoter

(2008) Raphaël Métivier et al.   NATURE

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

(2008) Wenqiang Yu et al.   NATURE

Genome-wide approaches to studying chromatin modifications

(2008) Dustin E. Schones et al.   NATURE REVIEWS GENETICS

Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators

(2008) V Tomaić et al.   ONCOGENE

Chemical approach toward efficient DNA methylation analysis

(2008) Akimitsu Okamoto   ORGANIC & BIOMOLECULAR CHEMISTRY

Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

(2008) C. Yauk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA DNA methylation signature for human cancer metastasis

(2008) A. Lujambio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA