Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells

Naturally occurring compounds in differentiation based therapy of cancer

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Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway

(2018) Jung Min Song et al.   CARCINOGENESIS

Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells

(2018) Jianhua Chen et al.   Molecular Medicine Reports

Overexpression of macrophage migration inhibitory factor and functionally‑related genes, D‑DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma

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Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach

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Autophagy inhibition improves anti-cancer drugs via FOXO3a activation

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Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

(2018) Mariachiara Buccarelli et al.   Cell Death & Disease

HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?

(2017) Danijela Maksimovic-Ivanic et al.   INTERNATIONAL JOURNAL OF CANCER

Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

(2017) Song Xue et al.   Journal of Hematology & Oncology

Chimeric antigen receptor T cells: a novel therapy for solid tumors

(2017) Shengnan Yu et al.   Journal of Hematology & Oncology

Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma

(2017) A Besse et al.   LEUKEMIA

Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells

(2017) Ji-Fan Lin et al.   Drug Design Development and Therapy

Effects of NO-Hybridization on the Immunomodulatory Properties of the HIV Protease Inhibitors Lopinavir and Ritonavir

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Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells

(2015) Richard E. Kast et al.   JOURNAL OF NEURO-ONCOLOGY

The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K

(2015) Danijela Maksimovic-Ivanic et al.   LEUKEMIA RESEARCH

Anticancer Effects of the Nitric Oxide-Modified Saquinavir Derivative Saquinavir-NO against Multidrug-Resistant Cancer Cells

(2015) Florian Rothweiler et al.   NEOPLASIA

Saquinavir-NO Inhibits IL-6 Production in Macrophages

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TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

(2014) J V Joseph et al.   Cell Death & Disease

HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway

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Transgenic analysis ofGFAPpromoter elements

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A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme

(2013) Michelle Alonso-Basanta et al.   JOURNAL OF NEURO-ONCOLOGY

Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis

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Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential

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Matrix Metalloproteinase-2 and -9 in Glioblastoma: A Trio of Old Drugs—Captopril, Disulfiram and Nelfinavir—Are Inhibitors with Potential as Adjunctive Treatments in Glioblastoma

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Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL

(2012) Marija Mojic et al.   CELL CYCLE

Glioblastoma cell line-derived spheres in serum-containing medium versus serum-free medium: A comparison of cancer stem cell properties

(2012) XIN HONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The new and less toxic protease inhibitor saquinavir–NO maintains anti-HIV-1 properties in vitro indistinguishable from those of the parental compound saquinavir

(2011) Filippo Canducci et al.   ANTIVIRAL RESEARCH

S-nitrosylation in the regulation of gene transcription

(2011) Yonggang Sha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells

(2011) Marco Donia et al.   CELL CYCLE

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice

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AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells

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Cytotoxic and immune-sensitizing properties of nitric oxide-modified saquinavir in iNOS-positive human melanoma cells

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Phase II trial of ritonavir/lopinavir in patients with progressive or recurrent high-grade gliomas

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Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism

(2010) Mahlon D. Johnson et al.   JOURNAL OF NEURO-ONCOLOGY

The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt

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