Circular RNAs in cancer: opportunities and challenges in the field

hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma

(2017) Xiaoli Zhu et al.   FEBS Journal

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis

(2017) Wei Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

(2017) Jian Zheng et al.   Journal of Hematology & Oncology

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

ZKSCAN1gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways

(2017) Zhicheng Yao et al.   Molecular Oncology

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family

(2017) L Chen et al.   ONCOGENE

Explaining negative kin discrimination in a cooperative mammal society

(2017) Faye J. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

The Epitranscriptome of Noncoding RNAs in Cancer

(2017) Manel Esteller et al.   Cancer Discovery

RNA in extracellular vesicles

(2017) Kyoung Mi Kim et al.   Wiley Interdisciplinary Reviews-RNA

Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma

(2016) Meilin Qin et al.   Cancer Biomarkers

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

(2016) Jlenia Guarnerio et al.   CELL

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma

(2016) Liangliang Xu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Defective control of pre–messenger RNA splicing in human disease

(2016) Benoit Chabot et al.   JOURNAL OF CELL BIOLOGY

Circular RNA expression in cutaneous squamous cell carcinoma

(2016) Michael Sand et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells

(2016) Huafang Su et al.   Journal of Translational Medicine

Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development

(2016) Xingchen Shang et al.   MEDICINE

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

(2016) Rémy Denzler et al.   MOLECULAR CELL

A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer

(2016) Fernando J. de Miguel et al.   Molecular Oncology

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Detecting circular RNAs: bioinformatic and experimental challenges

(2016) Linda Szabo et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1

(2016) Amaresh C. Panda et al.   NUCLEIC ACIDS RESEARCH

Circular RNA profile in gliomas revealed by identification tool UROBORUS

(2016) Xiaofeng Song et al.   NUCLEIC ACIDS RESEARCH

Long-noncoding RNAs in basal cell carcinoma

(2016) Michael Sand et al.   TUMOR BIOLOGY

Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer

(2016) Jia-ni Guo et al.   OncoTargets and Therapy

Circular RNA expression in basal cell carcinoma

(2016) Michael Sand et al.   Epigenomics

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

CircRNAs in hematopoiesis and hematological malignancies

(2016) A Bonizzato et al.   Blood Cancer Journal

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

(2016) R. Rupaimoole et al.   Cancer Discovery

Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread

(2016) Anna Bachmayr-Heyda et al.   Oncotarget

Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations

(2016) Derya Aslan et al.   Oncotarget

Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation

(2016) Wenjia Xia et al.   Scientific Reports

Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma

(2016) Zhenyu Zhong et al.   Scientific Reports

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNANovelty and Significance

(2015) Jes-Niels Boeckel et al.   CIRCULATION RESEARCH

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

(2015) Peifei Li et al.   CLINICA CHIMICA ACTA

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparison of circular RNA prediction tools

(2015) Thomas B. Hansen et al.   NUCLEIC ACIDS RESEARCH

Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis

(2015) W Yang et al.   ONCOGENE

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

(2015) F J Kohlhapp et al.   ONCOGENE

CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

(2015) Dawood B. Dudekula et al.   RNA Biology

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

(2015) Fang Li et al.   Oncotarget

Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

(2015) Davide Barbagallo et al.   Oncotarget

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Circular RNA biogenesis can proceed through an exon-containing lariat precursor

(2015) Steven P Barrett et al.   eLife

cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway

(2015) Guanli Huang et al.   PLoS One

Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

(2015) Sebastian Memczak et al.   PLoS One

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

Circular RNAs are depleted of polymorphisms at microRNA binding sites

(2014) Laurent F. Thomas et al.   BIOINFORMATICS

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva

(2014) J. H. Bahn et al.   CLINICAL CHEMISTRY

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

(2014) Feng-Yang Zong et al.   PLoS Genetics

Circular RNA and miR-7 in Cancer

(2013) T. B. Hansen et al.   CANCER RESEARCH

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

The need for transparency and good practices in the qPCR literature

(2013) Stephen A Bustin et al.   NATURE METHODS

ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry

(2013) F. A. Karreth et al.   Cancer Discovery

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY