Brain Lactate Metabolism: The Discoveries and the Controversies

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

(2016) Bjørn Quistorff et al.   Aging-US

Simultaneous measurement of glucose transport and utilization in the human brain

(2011) Alexander A. Shestov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dynamic monitoring of cytosolic glucose in single astrocytes

(2011) Mateja Prebil et al.   GLIA

Response to ‘Comment on Recent Modeling Studies of Astrocyte—Neuron Metabolic Interactions’: Much ado about Nothing

(2011) Silvia Mangia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fast and Reversible Stimulation of Astrocytic Glycolysis by K+ and a Delayed and Persistent Effect of Glutamate

(2011) C. X. Bittner et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of Surface Glucose Transporter-3

(2011) J. M. Ferreira et al.   JOURNAL OF NEUROSCIENCE

Intrinsic Bioenergetic Properties and Stress Sensitivity of Dopaminergic Synaptosomes

(2011) S. W. Choi et al.   JOURNAL OF NEUROSCIENCE

In Vivo Evidence for Lactate as a Neuronal Energy Source

(2011) M. T. Wyss et al.   JOURNAL OF NEUROSCIENCE

High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio

(2011) B. Quistorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors

(2011) M. Lavialle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Brain Activation

(2010) Gerald A. Dienel et al.   Annals of the New York Academy of Sciences

Hyperglycaemia and Diabetes Impair Gap Junctional Communication among Astrocytes

(2010) Gautam K Gandhi et al.   ASN Neuro

Morphology and dynamics of perisynaptic glia

(2010) Andreas Reichenbach et al.   BRAIN RESEARCH REVIEWS

Calcium clearance and its energy requirements in cerebellar neurons

(2010) Maxim V. Ivannikov et al.   CELL CALCIUM

Mitochondrial ion circuits

(2010) David G. Nicholls   Essays in Biochemistry

Energetics of Inhibition: Insights with a Computational Model of the Human GABAergic Neuron–Astrocyte Cellular Complex

(2010) Rossana Occhipinti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glycogenolysis in Astrocytes Supports Blood-Borne Glucose Channeling Not Glycogen-Derived Lactate Shuttling to Neurons: Evidence from Mathematical Modeling

(2010) Mauro DiNuzzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comment on Recent Modeling Studies of Astrocyte–Neuron Metabolic Interactions

(2010) Renaud Jolivet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Glutamine Synthesis Requires Neuronal-Born Aspartate as Amino Donor for Glial Glutamate Formation

(2010) Beatriz Pardo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

(2010) F. Boumezbeur et al.   JOURNAL OF NEUROSCIENCE

Dynamic activation model for a glutamatergic neurovascular unit

(2010) Daniela Calvetti et al.   JOURNAL OF THEORETICAL BIOLOGY

Regional aerobic glycolysis in the human brain

(2010) S. Neil Vaishnavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of glutamate in neuron-glia metabolic coupling

(2009) Pierre J Magistretti   AMERICAN JOURNAL OF CLINICAL NUTRITION

Spare respiratory capacity, oxidative stress and excitotoxicity

(2009) David G. Nicholls   BIOCHEMICAL SOCIETY TRANSACTIONS

Glucose and lactate supply to the synapse

(2009) L. Felipe Barros et al.   BRAIN RESEARCH REVIEWS

Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process

(2009) Karin Pierre et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Calcium Signaling in Brain Mitochondria

(2009) Laura Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Glucose Uptake Rather than Lactate Shuttle Take Center Stage in Subserving Neuroenergetics: Evidence from Mathematical Modeling

(2009) Mauro DiNuzzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

(2009) Gautam K. Gandhi et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

Simultaneous single neuron recording of O2consumption, [Ca2+]iand mitochondrial membrane potential in glutamate toxicity

(2009) Marc Gleichmann et al.   JOURNAL OF NEUROCHEMISTRY

Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways

(2009) Gerald A. Dienel et al.   JOURNAL OF NEUROCHEMISTRY

Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas

(2009) Tiago B. Rodrigues et al.   JOURNAL OF NEUROCHEMISTRY

Direct measurement of oxidative metabolism in the living brain by microdialysis: a review

(2009) H. Ronald Zielke et al.   JOURNAL OF NEUROCHEMISTRY

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

(2009) Sung W. Choi et al.   JOURNAL OF NEUROCHEMISTRY

Thein vivoneuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation

(2009) Silvia Mangia et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

(2009) P. Weisova et al.   JOURNAL OF NEUROSCIENCE

Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders

(2009) Y Zhao et al.   MOLECULAR PSYCHIATRY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation

(2009) C. William Shuttleworth   NEUROCHEMISTRY INTERNATIONAL

Balancing Structure and Function at Hippocampal Dendritic Spines

(2008) Jennifer N Bourne et al.   Annual Review of Neuroscience

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes

(2008) Shun Yu et al.   BRAIN RESEARCH

Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons

(2008) Gauri H. Malthankar-Phatak et al.   BRAIN RESEARCH

Brain energetics (thought needs food)

(2008) Luc Pellerin   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lactate fuels the human brain during exercise

(2008) Bjørn Quistorff et al.   FASEB JOURNAL

Stimulation-Induced Increases of Astrocytic Oxidative Metabolism in Rats and Humans Investigated with 1-11C-Acetate

(2008) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolic and Hemodynamic Events after Changes in Neuronal Activity: Current Hypotheses, Theoretical Predictions and in vivo NMR Experimental Findings

(2008) Silvia Mangia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte-Neuron Lactate-Shuttle Hypothesis

(2008) J. S. Erlichman et al.   JOURNAL OF NEUROSCIENCE

Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellumin vivo

(2008) Kirsten Caesar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE