Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

Pathological ATPergic Signaling in Major Depression and Bipolar Disorder

(2020) Peter Illes et al.   Frontiers in Molecular Neuroscience

The P2X7 receptor: a new therapeutic target in Alzheimer’s disease

(2019) Peter Illes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

Targeting P2X4 and P2X7 receptors in multiple sclerosis

(2019) María Domercq et al.   CURRENT OPINION IN PHARMACOLOGY

P2Y 13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release

(2019) Vasiliki Kyrargyri et al.   GLIA

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease

(2019) Melissa Crabbé et al.   Frontiers in Neuroscience

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Astroglia-Derived ATP Modulates CNS Neuronal Circuits

(2019) Peter Illes et al.   TRENDS IN NEUROSCIENCES

The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases

(2018) Amber Ou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Targeting metabotropic glutamate receptors for the treatment of neuroinflammation

(2018) Francesco Fazio et al.   CURRENT OPINION IN PHARMACOLOGY

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

(2018) Alazne Zabala et al.   EMBO Molecular Medicine

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

The Elusive P2X7 Macropore

(2018) Francesco Di Virgilio et al.   TRENDS IN CELL BIOLOGY

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2018) Emilie Faivre et al.   Frontiers in Molecular Neuroscience

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

(2018) Luiz E. B. Savio et al.   Frontiers in Pharmacology

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

(2018) Chris N. J. Young et al.   Frontiers in Chemistry

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

Epigenetics Control Microglia Plasticity

(2018) Mathilde Cheray et al.   Frontiers in Cellular Neuroscience

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn

(2018) Ryuji Terayama et al.   EXPERIMENTAL BRAIN RESEARCH

Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury

(2018) Marina Colella et al.   Frontiers in Neurology

Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis

(2018) Ljiljana Nikolic et al.   GLIA

Microglia and the Purinergic Signaling System

(2018) Stefano Calovi et al.   NEUROSCIENCE

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

(2018) Fan Meng et al.   BRAIN

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations

(2017) Claire Tronel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of microglial P2X7: modulation of cell death and cytokine release

(2017) Yingbo He et al.   Journal of Neuroinflammation

Neuronal P2X7 Receptors Revisited: Do They Really Exist?

(2017) Peter Illes et al.   JOURNAL OF NEUROSCIENCE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

A 2B adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway

(2017) Stefania Merighi et al.   PHARMACOLOGICAL RESEARCH

Microglia in CNS development: Shaping the brain for the future

(2017) Coralie-Anne Mosser et al.   PROGRESS IN NEUROBIOLOGY

P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia

(2017) Paola Fabbrizio et al.   Frontiers in Cellular Neuroscience

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches

(2017) Maria Concetta Geloso et al.   Frontiers in Aging Neuroscience

The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy

(2017) Edward Beamer et al.   Frontiers in Neuroscience

P2X4: A fast and sensitive purinergic receptor

(2017) Jaanus Suurväli et al.   Biomedical Journal

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain

(2017) Marina Matyash et al.   PLoS One

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4and A1receptors

(2016) Jimmy George et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The microglial ATP-gated ion channel P2X7 as a CNS drug target

(2016) Anindya Bhattacharya et al.   GLIA

Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia

(2016) Eva Beins et al.   GLIA

Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

(2016) Mastura Monif et al.   Journal of Neuroinflammation

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

(2016) Giacomo Casella et al.   Journal of Neuroinflammation

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

(2016) Xin-Hong Wang et al.   Molecular Medicine Reports

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

(2016) L Caetano et al.   MOLECULAR PSYCHIATRY

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

(2016) Oihane Abiega et al.   PLOS BIOLOGY

Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid

(2015) Annette Masuch et al.   GLIA

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts

(2015) Michael D. Lovelace et al.   STEM CELLS

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

(2014) Gennady G. Yegutkin   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

(2014) S. Apolloni et al.   Disease Models & Mechanisms

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Adenosine Receptors: Expression, Function and Regulation

(2014) Sandeep Sheth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor

(2014) Paolo Gelosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth

(2014) L. Dissing-Olesen et al.   JOURNAL OF NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

(2014) Stefka Gyoneva et al.   NEUROBIOLOGY OF DISEASE

Nucleoside transporters in the purinome

(2014) Alexandre dos Santos-Rodrigues et al.   NEUROCHEMISTRY INTERNATIONAL

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

(2014) Marta R.S. Carmo et al.   NEUROPHARMACOLOGY

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission

(2014) Youichi Shinozaki et al.   Scientific Reports

Inhibition of P2X4 function by P2Y6 UDP receptors in microglia

(2013) Louis-Philippe Bernier et al.   GLIA

The A1 adenosine receptor as a new player in microglia physiology

(2013) L. Luongo et al.   GLIA

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Involvement of P2X4 receptors in hippocampal microglial activation afterstatus epilepticus

(2013) Lauriane Ulmann et al.   GLIA

Classical and unconventional pathways of vesicular release in microglia

(2013) Ilaria Prada et al.   GLIA

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

P2Y4 Receptor-Mediated Pinocytosis Contributes to Amyloid Beta-Induced Self-Uptake by Microglia

(2013) H.-q. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Microglial P2Y12 Deficiency/Inhibition Protects against Brain Ischemia

(2013) Corey M. Webster et al.   PLoS One

Neurotransmitter signaling in the pathophysiology of microglia

(2013) María Domercq et al.   Frontiers in Cellular Neuroscience

Microglial migration mediated by ATP-induced ATP release from lysosomes

(2012) Ying Dou et al.   CELL RESEARCH

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

P2X4 receptor channels form large noncytolytic pores in resting and activated microglia

(2012) Louis-Philippe Bernier et al.   GLIA

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Development and homeostasis of “resident” myeloid cells: The case of the microglia

(2012) Elisa Gomez Perdiguero et al.   GLIA

Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion

(2012) C. Rigato et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Microglia and neuronal cell death

(2012) José L. Marín-Teva et al.   Neuron Glia Biology

Molecular and functional properties of P2X receptors—recent progress and persisting challenges

(2012) Karina Kaczmarek-Hájek et al.   Purinergic Signalling

NTPDase1 activity attenuates microglial phagocytosis

(2012) Larisa Bulavina et al.   Purinergic Signalling

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development

(2011) Knut Biber et al.   EMBO JOURNAL

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks

(2011) C. Rigato et al.   GLIA

Adenosine Augments IL-10 Production by Microglial Cells through an A2B Adenosine Receptor-Mediated Process

(2011) B. Koscso et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

P2X Receptors and Their Roles in Astroglia in the Central and Peripheral Nervous System

(2011) Peter Illes et al.   NEUROSCIENTIST

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling: From normal behaviour to pathological brain function

(2011) Geoffrey Burnstock et al.   PROGRESS IN NEUROBIOLOGY

Adenosine 2A receptor: a crucial neuromodulator with bidirectional effect in neuroinflammation and brain injury

(2011) Shuang-Shuang Dai et al.   REVIEWS IN THE NEUROSCIENCES

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

The birth and postnatal development of purinergic signalling

(2010) G. Burnstock et al.   Acta Physiologica

Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia

(2010) W Nörenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Rodent Cortical Astroglia Express In Situ Functional P2X7 Receptors Sensing Pathologically High ATP Concentrations

(2010) João Filipe Oliveira et al.   CEREBRAL CORTEX

Early adenosine receptor activation ameliorates spinal cord reperfusion injury

(2010) T Brett Reece et al.   Journal of Cardiovascular Medicine

Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice

(2010) M. Lee Haselkorn et al.   JOURNAL OF NEUROTRAUMA

Evolutionary origins of the purinergic signalling system

(2009) G. Burnstock et al.   Acta Physiologica

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

P2Y12 Receptor Protein in Cortical Gray Matter Lesions in Multiple Sclerosis

(2009) S. Amadio et al.   CEREBRAL CORTEX

Novel investigational adenosine A2Areceptor antagonists for Parkinson's disease

(2009) Annalisa Pinna   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X7receptor action

(2009) Kuan-Min Fang et al.   JOURNAL OF NEUROCHEMISTRY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Evolution of the neocortex: a perspective from developmental biology

(2009) Pasko Rakic   NATURE REVIEWS NEUROSCIENCE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

(2008) Anthony J Sharp et al.   Journal of Neuroinflammation

P2Y12 Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

(2008) K. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia

(2008) Yasuhiro Irino et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

The ectonucleotidasecd39/ENTPDase1 modulates purinergic-mediated microglial migration

(2007) Katrin Färber et al.   GLIA

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING