Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

(2015) Lili Feng et al.   NEOPLASIA

Prostatic acid phosphatase is the main acid phosphatase with 5′-ectonucleotidase activity in the male mouse saliva and regulates salivation

(2014) César L. Araujo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Early Prediction of Persistent Organ Failure by Soluble CD73 in Patients With Acute Pancreatitis*

(2014) Mikael Maksimow et al.   CRITICAL CARE MEDICINE

The many isoforms of human adenylate kinases

(2014) Christakis Panayiotou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CD73-Generated Adenosine Restricts Lymphocyte Migration into Draining Lymph Nodes

(2014) Masahide Takedachi et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

CD73-TNAP crosstalk regulates the hypertrophic response and cardiomyocyte calcification due to α1 adrenoceptor activation

(2014) Xiaohong Tracey Gan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

(2014) Paulina Navon Elkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

A new, sensitive ecto-5′-nucleotidase assay for compound screening

(2013) Marianne Freundlieb et al.   ANALYTICAL BIOCHEMISTRY

Ecto-5′-Nucleotidase, CD73, Is an Endothelium-Derived Hyperpolarizing Factor Synthase

(2013) Masanori Ohta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel hypothesis for an alkaline phosphatase ‘rescue’ mechanism in the hepatic acute phase immune response

(2013) Adrianne F. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ecto-5′-Nucleotidase on Immune Cells Protects From Adverse Cardiac Remodeling

(2013) Florian Bönner et al.   CIRCULATION RESEARCH

Large-volume sample stacking with polarity switching for monitoring of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) reactions by capillary electrophoresis

(2013) Sang-Yong Lee et al.   ELECTROPHORESIS

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

(2013) Matthew Pettengill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Purinergic Signal Metabolism by Ectonucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke

(2013) Ronald A. Albright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Tissue-Nonspecific Alkaline Phosphatase Acts Redundantly with PAP and NT5E to Generate Adenosine in the Dorsal Spinal Cord

(2013) S. E. Street et al.   JOURNAL OF NEUROSCIENCE

Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus

(2013) Mark J. Wall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Therapeutic Potentials of Ecto-Nucleoside Triphosphate Diphosphohydrolase, Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto-5′-Nucleotidase, and Alkaline Phosphatase Inhibitors

(2013) Mariya al-Rashida et al.   MEDICINAL RESEARCH REVIEWS

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Intestinal alkaline phosphatase: novel functions and protective effects

(2013) Jean-Paul Lallès   NUTRITION REVIEWS

Transmembrane Prostatic Acid Phosphatase (TMPAP) Interacts with Snapin and Deficient Mice Develop Prostate Adenocarcinoma

(2013) Ileana B. Quintero et al.   PLoS One

Role of the ectonucleotidase NTPDase2 in taste bud function

(2013) Aurelie Vandenbeuch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Evolutionary origins of taste buds: phylogenetic analysis of purinergic neurotransmission in epithelial chemosensors

(2013) M. Kirino et al.   Open Biology

The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study

(2013) Geoff Bellingan et al.   Lancet Respiratory Medicine

Adenosine Signaling

(2012) Jiaming Wen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enzyme-coupled assays for simultaneous detection of nanomolar ATP, ADP, AMP, adenosine, inosine and pyrophosphate concentrations in extracellular fluids

(2012) Mikko Helenius et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NPP4 is a procoagulant enzyme on the surface of vascular endothelium

(2012) R. A. Albright et al.   BLOOD

Outcome of hematopoietic stem cell transplantation for adenosine deaminase-deficient severe combined immunodeficiency

(2012) A. Hassan et al.   BLOOD

New insights into NPP1 function: Lessons from clinical and animal studies

(2012) N.C.W. Mackenzie et al.   BONE

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Lack of ecto-5′-nucleotidase (CD73) promotes arteriogenesis

(2012) Yang Chul Böring et al.   CARDIOVASCULAR RESEARCH

Mechanisms of ATP release and signalling in the blood vessel wall

(2012) A. W. Lohman et al.   CARDIOVASCULAR RESEARCH

Crystal Structure of a Soluble Form of Human CD73 with Ecto-5′-Nucleotidase Activity

(2012) Dominic P. H. M. Heuts et al.   CHEMBIOCHEM

Adenosine Deaminase in the Modulation of Immune System and its Potential as a Novel Target for Treatment of Inflammatory Disorders

(2012) Luca Antonioli et al.   CURRENT DRUG TARGETS

Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities

(2012) Gennady G. Yegutkin et al.   FASEB JOURNAL

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5′-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities

(2012) Sang-Yong Lee et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

(2012) T. Kusu et al.   JOURNAL OF IMMUNOLOGY

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

ENTPD1/CD39 is a promising therapeutic target in oncology

(2012) J Bastid et al.   ONCOGENE

Increased CD39 Nucleotidase Activity on Microparticles from Patients with Idiopathic Pulmonary Arterial Hypertension

(2012) Scott H. Visovatti et al.   PLoS One

CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system

(2012) D. A. Mahamed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium

(2012) Elisabet Aliagas et al.   Purinergic Signalling

Purines as potential morphogens during embryonic development

(2012) Karine Massé et al.   Purinergic Signalling

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification

(2012) Silvia Jansen et al.   STRUCTURE

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Origin, utilization, and recycling of nucleosides in the central nervous system

(2011) Piero Luigi Ipata   ADVANCES IN PHYSIOLOGY EDUCATION

Impaired ATP-Induced Coronary Blood Flow and Diminished Aortic NTPDase Activity Precede Lesion Formation in Apolipoprotein E–Deficient Mice

(2011) Nathalie Mercier et al.   AMERICAN JOURNAL OF PATHOLOGY

Ectonucleotidases in the digestive system: focus on NTPDase3 localization

(2011) Elise G. Lavoie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver

(2011) Michel Fausther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle

(2011) Ricardo Villa-Bellosta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells

(2011) Gennady G. Yegutkin et al.   ANGIOGENESIS

Different role of CD73 in leukocyte trafficking via blood and lymph vessels

(2011) A. Algars et al.   BLOOD

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

(2011) A. V. Sauer et al.   BLOOD

A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling

(2011) N Yokdang et al.   BRITISH JOURNAL OF CANCER

Autotaxin and LPA receptor signaling in cancer

(2011) Anna J. S. Houben et al.   CANCER AND METASTASIS REVIEWS

Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice

(2011) Anja Buchheiser et al.   CARDIOVASCULAR RESEARCH

Fluorescent and colorimetric chemosensors for detection of nucleotides, FAD and NADH: highlighted research during 2004–2010

(2011) Ying Zhou et al.   CHEMICAL SOCIETY REVIEWS

Genetics in Arterial Calcification

(2011) Frank Rutsch et al.   CIRCULATION RESEARCH

Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator

(2011) Hua Fan et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression

(2011) Gennady G. Yegutkin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a reversed electrode polarity switching mode

(2011) Jamshed Iqbal et al.   JOURNAL OF CHROMATOGRAPHY A

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Crystallographic Evidence for a Domain Motion in Rat Nucleoside Triphosphate Diphosphohydrolase (NTPDase) 1

(2011) Matthias Zebisch et al.   JOURNAL OF MOLECULAR BIOLOGY

ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer

(2011) Jian Pan et al.   Journal of Translational Medicine

Insights into autotaxin: how to produce and present a lipid mediator

(2011) Wouter H. Moolenaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Learning about the functions of NME/NM23: lessons from knockout mice to silencing strategies

(2011) Mathieu Boissan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Measurement of purine release with microelectrode biosensors

(2011) Nicholas Dale et al.   Purinergic Signalling

The GDA1_CD39 superfamily: NTPDases with diverse functions

(2011) Aileen F. Knowles   Purinergic Signalling

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Pain-relieving prospects for adenosine receptors and ectonucleotidases

(2011) Mark J. Zylka   TRENDS IN MOLECULAR MEDICINE

Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion

(2010) Elise G. Lavoie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Novel Mechanism of γ/δ T-Lymphocyte and Endothelial Activation by Shear Stress

(2010) Yi Fu et al.   CIRCULATION RESEARCH

Tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) as a serum maker for cancer with bone metastasis

(2010) Tsu-Yi Chao et al.   CLINICA CHIMICA ACTA

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

(2010) Anton V. Zavialov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice

(2010) G. G. Yegutkin et al.   JOURNAL OF IMMUNOLOGY

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages

(2010) A. V. Zavialov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ecto-5'-Nucleotidase (CD73) Inhibits Nociception by Hydrolyzing AMP to Adenosine in Nociceptive Circuits

(2010) N. A. Sowa et al.   JOURNAL OF NEUROSCIENCE

Advances in-capillary electrophoretic enzyme assays

(2010) Yi Fan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2010) Yang Zhou et al.   PLoS One

Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation

(2010) R. Corriden et al.   Science Signaling

Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells

(2009) Domenick A. Prosdocimo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis

(2009) Iain L.O. Buxton et al.   CANCER LETTERS

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse

(2009) Gilles Kauffenstein et al.   CARDIOVASCULAR RESEARCH

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing

(2009) Petras Dzeja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nucleoside-5′-monophosphates as Prodrugs of Adenosine A2AReceptor Agonists Activated by ecto-5′-Nucleotidase†† Contribution to celebrate the 100th anniversary of the Division of Medicinal Chemistry of the American Chemical Society.

(2009) Ali El-Tayeb et al.   JOURNAL OF MEDICINAL CHEMISTRY

The NM23 family in development

(2009) Aikaterini Bilitou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pediatric neurological syndromes and inborn errors of purine metabolism

(2009) Marcella Camici et al.   NEUROCHEMISTRY INTERNATIONAL

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostatic acid phosphatase, a neglected ectonucleotidase

(2009) Herbert Zimmermann   Purinergic Signalling

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

(2008) Gennady G. Yegutkin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation

(2008) Yara Banz et al.   BRITISH JOURNAL OF HAEMATOLOGY

Distribution of ectonucleotidases in the rodent brain revisited

(2008) David Langer et al.   CELL AND TISSUE RESEARCH

Ecto-5′ Nucleotidase (CD73)-Mediated Adenosine Generation and Signaling in Murine Cardiac Allograft Vasculopathy

(2008) Tomomi Hasegawa et al.   CIRCULATION RESEARCH

A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions

(2008) Jamshed Iqbal et al.   ELECTROPHORESIS

IFN-β regulates CD73 and adenosine expression at the blood-brain barrier

(2008) Jussi Niemelä et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNAP, TrAP, ecto-purinergic signaling, and bone remodeling

(2008) Jonathan D. Kaunitz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

(2008) Tiejuan Mi et al.   JOURNAL OF CLINICAL INVESTIGATION

Possible Effects of Microbial Ecto-Nucleoside Triphosphate Diphosphohydrolases on Host-Pathogen Interactions

(2008) F. M. Sansom et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation

(2008) Luci Bavaresco et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

(2008) Ulrich Pannicke et al.   NATURE GENETICS

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Prostatic Acid Phosphatase Is an Ectonucleotidase and Suppresses Pain by Generating Adenosine

(2008) Mark J. Zylka et al.   NEURON

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES

Capillary electrophoresis-based nanoscale assays for monitoring ecto-5′-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes

(2007) Jamshed Iqbal et al.   ANALYTICAL BIOCHEMISTRY