The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Additive amelioration of ALS by co-targeting independent pathogenic mechanisms

(2017) Ashley E. Frakes et al.   Annals of Clinical and Translational Neurology

Telomere shortening leads to earlier age of onset in ALS mice

(2016) Birgit Linkus et al.   Aging-US

OldversusNew Mechanisms in the Pathogenesis of ALS

(2016) Simona Rossi et al.   BRAIN PATHOLOGY

scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway

(2016) Ying Wang et al.   BRAIN RESEARCH

MicroRNA-125b regulates microglia activation and motor neuron death in ALS

(2016) C Parisi et al.   CELL DEATH AND DIFFERENTIATION

Comparative morphometric analysis of microglia in the spinal cord of SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2016) Tomohiro Ohgomori et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic administration of AMD3100 increases survival and alleviates pathology in SOD1G93A mice model of ALS

(2016) Inna Rabinovich-Nikitin et al.   Journal of Neuroinflammation

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

(2016) Savina Apolloni et al.   Journal of Neuroinflammation

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1

(2016) M. Gravel et al.   JOURNAL OF NEUROSCIENCE

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

(2016) Chiara Parisi et al.   MEDIATORS OF INFLAMMATION

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

(2016) Aaron R. Haeusler et al.   NATURE REVIEWS NEUROSCIENCE

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

(2016) Chunxing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43/FUS in motor neuron disease: Complexity and challenges

(2016) Erika N. Guerrero et al.   PROGRESS IN NEUROBIOLOGY

C9orf72 is required for proper macrophage and microglial function in mice

(2016) J. G. ORourke et al.   SCIENCE

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

(2016) Seshiru Nakazawa et al.   Nature Communications

Predicting disease progression in amyotrophic lateral sclerosis

(2016) Albert A. Taylor et al.   Annals of Clinical and Translational Neurology

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Kid on the Block: Does Histamine Get Along with Inflammation in Amyotrophic Lateral Sclerosis?

(2015) Cinzia Volonte et al.   CNS & Neurological Disorders-Drug Targets

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

(2015) Weihua Zhao et al.   EXPERIMENTAL NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

(2014) S. Apolloni et al.   Disease Models & Mechanisms

Pattern recognition receptors and central nervous system repair

(2014) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Glial cells in amyotrophic lateral sclerosis

(2014) T. Philips et al.   EXPERIMENTAL NEUROLOGY

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

(2014) Katherine E Lewis et al.   Journal of Neuroinflammation

Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

(2014) Satoru Tada et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2014) Savina Apolloni et al.   MOLECULAR NEUROBIOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology

(2013) Elisa Teyssou et al.   ACTA NEUROPATHOLOGICA

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis

(2013) Chang Zhou et al.   Journal of Neuroinflammation

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats

(2013) Maria Nikodemova et al.   NEUROBIOLOGY OF DISEASE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Motor neuron dysfunction in a mouse model of ALS: Gender-dependent effect of P2X7 antagonism

(2013) Chiara Cervetto et al.   TOXICOLOGY

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Histamine modulates microglia function

(2012) Raquel Ferreira et al.   Journal of Neuroinflammation

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis

(2012) Yannick Nicolas Gerber et al.   PLoS One

The changing phenotype of microglia from homeostasis to disease

(2012) Xiao-Guang Luo et al.   Translational Neurodegeneration

Familial versus sporadic amyotrophic lateral sclerosis--a false dichotomy?

(2011) K. Talbot   BRAIN

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

dl-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis

(2011) Xinhong Feng et al.   NEUROPHARMACOLOGY

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

(2010) David R. Beers et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice

(2010) A. Florence Keller et al.   EXPERIMENTAL NEUROLOGY

Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models

(2010) Eun Jin Yang et al.   Journal of Neuroinflammation

AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

(2010) James C Dodge et al.   MOLECULAR THERAPY

Mutant superoxide dismutase 1-induced IL-1  accelerates ALS pathogenesis

(2010) F. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase

(2009) Genevieve Gowing et al.   EXPERIMENTAL NEUROLOGY

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

(2009) N. D'Ambrosi et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

(2009) Yasushi Ito et al.   NEUROBIOLOGY OF DISEASE

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

Membrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events

(2008) Savina Apolloni et al.   FEBS Journal

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY