Microglial P2Y12 Deficiency/Inhibition Protects against Brain Ischemia

P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells

(2012) Christian Gachet   Purinergic Signalling

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

(2011) S. Nisar et al.   BLOOD

Ion Channels on Microglia: Therapeutic Targets for Neuroprotection

(2011) Stephen D. Skaper   CNS & Neurological Disorders-Drug Targets

Adenosine and ATP Receptors in the Brain

(2011) Geoffrey Burnstock et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

(2010) Mitsuyo Maeda et al.   GLIA

On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

(2010) Daniel Marcellino et al.   JOURNAL OF NEURAL TRANSMISSION

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Possible Involvement of P2X7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats

(2008) Daijiro Yanagisawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Purinergic systems in microglia

(2008) K. Inoue   CELLULAR AND MOLECULAR LIFE SCIENCES

FasL shedding is reduced by hypothermia in experimental stroke

(2008) Liping Liu et al.   JOURNAL OF NEUROCHEMISTRY

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

(2008) Anthony J Sharp et al.   Journal of Neuroinflammation

P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

(2008) H. Tozaki-Saitoh et al.   JOURNAL OF NEUROSCIENCE

Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia

(2008) Yasuhiro Irino et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study

(2008) Hans-Christoph Diener et al.   LANCET NEUROLOGY

Inflammation and NFκB activation is decreased by hypothermia following global cerebral ischemia

(2008) Carla M. Webster et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells

(2008) Simona Eleuteri et al.   NEUROSCIENCE LETTERS