Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins

(2020) Adrián Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study

(2020) Di Sotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemosensitization of hepatocellular carcinoma cells to sorafenib by β-caryophyllene oxide-induced inhibition of ABC export pumps

(2019) Silvia Di Giacomo et al.   ARCHIVES OF TOXICOLOGY

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

(2019) Chin-Yap Loh et al.   Frontiers in Oncology

Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization

(2019) Sreevidya Mallappa et al.   MOLECULAR CARCINOGENESIS

Signaling networks in cholangiocarcinoma: molecular pathogenesis, targeted therapies and drug resistance

(2019) Laura Fouassier et al.   LIVER INTERNATIONAL

Medical treatment for cholangiocarcinoma

(2019) Jorge Adeva et al.   LIVER INTERNATIONAL

Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy

(2019) Elisa Lozano et al.   HEPATOLOGY

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

(2019) Tânia Capelôa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

β-caryophyllene, a dietary phytocannabinoid attenuates oxidative stress, inflammation, apoptosis and prevents structural alterations of the myocardium against doxorubicin-induced acute cardiotoxicity in rats: An in vitro and in vivo study

(2019) Hasan Al-Taee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoglycemic, Antiglycation, and Cytoprotective Properties of a Phenol-Rich Extract From Waste Peel of Punica granatum L. var. Dente di Cavallo DC2

(2019) Antonella Di Sotto et al.   MOLECULES

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

(2019) Jong Hyun Lee et al.   Biomolecules

Targeting DNA repair in cancer: current state and novel approaches

(2019) Apostolos Klinakis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice

(2019) Paulina Chávez-Hurtado et al.   JOURNAL OF MEDICINAL FOOD

Cellular and molecular mechanisms of liver regeneration: Proliferation, growth, death and protection of hepatocytes

(2019) Michitaka Ozaki   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway – An in-vitro and in-silico study

(2019) Duraisamy Ramachandhiran et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Attenuation of STAT3 Signaling Cascade by Daidzin Can Enhance the Apoptotic Potential of Bortezomib against Multiple Myeloma

(2019) Min Hee Yang et al.   Biomolecules

Chemoresistance and chemosensitization in cholangiocarcinoma

(2018) Jose J.G. Marin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-Caryophyllene (BCP) ameliorates MPP+ induced cytotoxicity

(2018) Guifang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of lactoferrin and its receptors on biliary epithelium

(2018) Romina Mancinelli et al.   BIOMETALS

Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer

(2018) Jin-Young Lee et al.   CANCER LETTERS

Natural compounds and combination therapy in colorectal cancer treatment

(2018) A. Rejhová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caryophyllane sesquiterpenes inhibit DNA-damage by tobacco smoke in bacterial and mammalian cells

(2018) Silvia Di Giacomo et al.   FOOD AND CHEMICAL TOXICOLOGY

Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells

(2018) P.S. Pavithra et al.   PHYTOMEDICINE

Non-clinical toxicity of β -caryophyllene, a dietary cannabinoid: Absence of adverse effects in female Swiss mice

(2018) George Laylson da Silva Oliveira et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Molecular bases of the poor response of liver cancer to chemotherapy

(2018) Jose J.G. Marin et al.   Clinics and Research in Hepatology and Gastroenterology

Effects of β-caryophyllene on arginine ADP-ribosyltransferase 1-mediated regulation of glycolysis in colorectal cancer under high-glucose conditions

(2018) Li Zhou et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

(2018) Jong Lee et al.   Cancers

SPC Liposomes as Possible Delivery Systems for Improving Bioavailability of the Natural Sesquiterpene β-Caryophyllene: Lamellarity and Drug-Loading as Key Features for a Rational Drug Delivery Design

(2018) Antonella Di Sotto et al.   Pharmaceutics

EGFR-mediated apoptosis via STAT3

(2017) Nicole M. Jackson et al.   EXPERIMENTAL CELL RESEARCH

Signaling pathways as therapeutic targets in biliary tract cancer

(2017) Jennifer Yang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma

(2017) Massimiliano Cadamuro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin

(2017) Ernestina M. De Francesco et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity

(2017) Donato Cappetta et al.   Oxidative Medicine and Cellular Longevity

Comparison of the adverse event profiles of conventional and liposomal formulations of doxorubicin using the FDA adverse event reporting system

(2017) Akiho Fukuda et al.   PLoS One

Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma

(2016) Nestor F. Esnaola et al.   CANCER

Combinatorial immunotherapy strategies for hepatocellular carcinoma

(2016) Maria Tagliamonte et al.   CURRENT OPINION IN IMMUNOLOGY

The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice

(2016) Nan Wu et al.   HEPATOLOGY

Toxicological Evaluation of β-Caryophyllene Oil

(2016) D. Schmitt et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

(2016) Roberta Visconti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

β-caryophyllene andβ-caryophyllene oxide-natural compounds of anticancer and analgesic properties

(2016) Klaudyna Fidyt et al.   Cancer Medicine

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein

(2015) Chiara Riganti et al.   CANCER LETTERS

Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

(2015) Jong Hyun Lee et al.   CANCER LETTERS

β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet–induced obese C57BL/6N mice

(2015) Jae In Jung et al.   CARCINOGENESIS

Mutagenicity of cigarette butt waste in the bacterial reverse mutation assay: The protective effects of β-caryophyllene and β-caryophyllene oxide

(2015) Silvia Di Giacomo et al.   ENVIRONMENTAL TOXICOLOGY

The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna

(2015) Saad Dahham et al.   MOLECULES

Interaction of β-caryophyllene and β-caryophyllene oxide with phospholipid bilayers: Differential scanning calorimetry study

(2015) Maria Grazia Sarpietro et al.   THERMOCHIMICA ACTA

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

(2015) J. Shen et al.   Cancer Discovery

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression

(2014) Hasaya Dokduang et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

(2014) Gautam Sethi et al.   Molecular Cancer

β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

(2014) Amine Bahi et al.   PHYSIOLOGY & BEHAVIOR

β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products

(2013) Chulwon Kim et al.   APOPTOSIS

β-caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase

(2013) Chulwon Kim et al.   MOLECULAR CARCINOGENESIS

Genotoxicity assessment of β-caryophyllene oxide

(2013) Antonella Di Sotto et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Expression of Multidrug Resistance-Associated Protein 2 in Human Gallbladder Carcinoma

(2013) Hyun-Soo Kim et al.   Biomed Research International

Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

(2012) Martin Štěrba et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network

(2012) Anne Trécul et al.   Genes and Nutrition

No Correlation between the Expression of FXR and Genes Involved in Multidrug Resistance Phenotype of Primary Liver Tumors

(2012) P. Martinez-Becerra et al.   MOLECULAR PHARMACEUTICS

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin

(2012) Ji-Eon Kim et al.   XENOBIOTICA

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways

(2011) S. Prakobwong et al.   CARCINOGENESIS

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

(2011) Veronika Hanušová et al.   DRUG METABOLISM REVIEWS

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

Galactosylated α,β-poly[(2-hydroxyethyl)-L-aspartamide]-bound doxorubicin

(2010) Xiaoyun Cheng et al.   ANTI-CANCER DRUGS

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo

(2010) Peramaiyan Rajendran et al.   CLINICAL CANCER RESEARCH

Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas

(2010) S. Rau et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Synergy research: Approaching a new generation of phytopharmaceuticals

(2010) Hildebert Wagner   FITOTERAPIA

STAT3 modulates the DNA damage response pathway

(2010) Seán P. Barry et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Inhibition by β-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes

(2010) Antonella Di Sotto et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Clastogenicity of Beta-Caryophyllene in Mouse

(2009) Dolores Molina-Jasso et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression

(2009) Giammarco Fava et al.   LIVER INTERNATIONAL

Antimutagenic and mutagenic activities of some terpenes in the bacterial reverse mutation assay

(2008) Antonella Di Sotto et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS