Article
Biochemistry & Molecular Biology
Abdullah Alsrhani, Abozer Y. Elderdery, Badr Alzahrani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok
Summary: Breast cancer is a common and increasing malignant disease, and there is a need for better treatment options. Nanotechnology, particularly albumin-based nanoparticles, has potential as a chemotherapy technique for cancer therapy. In this study, albumin visnagin nanoparticles were synthesized and characterized, and their efficacy in suppressing breast cancer cells was examined.
Article
Genetics & Heredity
Ana Paco, Joana Leitao-Castro, Renata Freitas
Summary: HOXB7 is often overexpressed in breast cancer cells and related to poor prognosis. Silencing HOXB7 in TNBC cells can lead to lower migration and invasion rates, as well as changes in CDH1 expression and DNA methylation, suggesting a potential therapeutic target for TNBC treatment.
Article
Biochemistry & Molecular Biology
Bao-Bao Yu, Hao Yuan, Yun-Cong Chen, Dan-Xia Zhou, Zhen-Ji Gan, Jie Wang, Jian-Xin Li, Zhu-Jun Yao
Summary: AA005 shows potential as a future therapeutic agent for TNBC by inhibiting cell growth and activating aerobic glycolysis pathway. AA005 also causes irreversible damage to cell activity and mitochondrial function, leading to cell death. In addition, the in vivo therapeutic efficacy of AA005 has been demonstrated in a mouse model.
Article
Oncology
Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye
Summary: Under conditions of tumor acidosis, the expression of PD-L1 significantly increases and it is likely mediated by activation of the STAT3 signaling pathway. This finding provides new insights into the study of tumor immune evasion mechanisms.
Article
Oncology
Romana Mikyskova, Olena Sapega, Miroslav Psotka, Ondrej Novotny, Zdenek Hodny, Sona Balintova, David Malinak, Jana Svobodova, Rudolf Andrys, David Rysanek, Kamil Musilek, Milan Reinis
Summary: The responsiveness of proliferating and docetaxel-induced senescent cancer cells to small molecule STAT3 inhibitor Stattic and its analogues was evaluated. Senescent cells were more resistant to these inhibitors and could affect the secretion of certain cytokines. This study provides useful information for further development of STAT3 inhibitor-based therapy for cancer or age-related diseases.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Oncology
Masoumeh Hajizadeh, Salar Hafez Ghoran, Hewa Jalal Azeez, Mohammad Ali Hosseinpour Feizi, Esmaeil Babaei
Summary: Gemini Curcumin (Gemini-Cur) is a nanoformulation of curcumin that exhibits significant apoptotic effects on cancer cell lines. This in vitro study demonstrates that Gemini-Cur suppresses the proliferation of MDA-MB-468 breast cancer cells in a time- and dose-dependent manner. The apoptotic effects are mediated through modulation of the expression of Bax, Bcl-2, survivin, and caspase-3.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Sushma Maharjan, Min-Gu Lee, So-Young Kim, Kyu-Shik Lee, Kyung-Soo Nam
Summary: Considerable emphasis is being placed on combinatorial chemotherapeutic/natural treatments for breast cancer. This study reveals the synergistic anti-tumor activity of morin and Doxorubicin (Dox) co-treatment on MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation. Morin/Dox treatment promoted Dox uptake and induced DNA damage and formation of nuclear foci of p-H2A.X. Furthermore, co-treatment attenuated the expression of DNA repair proteins, cell cycle proteins, and FOXM1, as well as downregulated the phosphorylation of EGFR and STAT3, resulting in suppression of TNBC cell growth.
Article
Oncology
Lin Niu, Songhe Yang, Xueying Zhao, Xiaochao Liu, Lina Si, Meng Wei, Lei Liu, Luyang Cheng, Yuebing Qiao, Zhihong Chen
Summary: The study found that sericin could effectively inhibit TNBC cell proliferation, induce cell cycle arrest, and promote cellular apoptosis, primarily by downregulating the PI3K/Akt signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ajda Coker-Gurkan, Esin Can, Semanur Sahin, Pinar Obakan-Yerlikaya, Elif-Damla Arisan
Summary: Atiprimod demonstrates inhibitory effects on breast cancer cell growth and apoptosis in vitro by affecting the activity of STAT3 and NF-kappa B, as well as inducing ER stress within the cells. In cell experiments, atiprimod shows great potential as an anti-cancer therapy.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Antonella Di Sotto, Marco Gulli, Marco Minacori, Romina Mancinelli, Stefania Garzoli, Ester Percaccio, Alessio Incocciati, Donatella Romaniello, Gabriela Mazzanti, Margherita Eufemi, Silvia Di Giacomo
Summary: This study evaluated the chemopreventive properties of the natural compound beta-caryophyllene against cigarette smoke condensate (CSC)-induced damage in breast cancer cells. It was found that beta-caryophyllene increased cell death, hindered cell recovery and migration, and inhibited a key signaling pathway. These findings suggest that beta-caryophyllene could be a novel strategy to reduce smoke-induced harm in cancer patients and improve survival in breast cancer women.
Article
Chemistry, Multidisciplinary
Shadi N. Kotob, Jessica L. Kelts
Summary: Vitamin D is a steroid hormone that inhibits cell growth. The triple-negative breast cancer cell lines MDA-MB-231 and MDA-MB-468 do not have growth suppression with vitamin D, while MCF-7 does. Mutations in the p53 gene in MDA-MB-231 and MDA-MB-468 may explain the lack of growth suppression. Reactivation of p53 using PRIMA-1(MET) does not restore the sensitivity of the triple-negative cells to vitamin D.
Article
Biochemistry & Molecular Biology
Sahika Cingir Koker, Banu Yalcin, Irem Dogan Turacli
Summary: Metformin, a commonly used drug for diabetes and cancer, was investigated in this study for its effects on breast cancer cell lines. The study found that metformin-resistant cells showed increased migration capacity and decreased sensitivity to PI3K inhibitors, suggesting the need to consider the subtype of breast cancer when evaluating the effects of metformin.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shenglin Wang, Yunqing Wang, Zhen Huang, Hongxiang Wei, Xinwen Wang, Rongkai Shen, Wenbin Lan, Guangxian Zhong, Jianhua Lin
Summary: This study confirms the moderate anti-tumor effects of gefitinib on osteosarcoma, via suppression of the PI3K/Akt and ERK pathways to reduce cell proliferation and migration. Combined treatment with stattic further enhances the inhibitory effects of gefitinib, reducing cell invasion and promoting apoptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Endocrinology & Metabolism
Chen Chen, Hong-ying Wang, Cheng-yu Chu, Wei Zhang, Yi-ting Jin, Qiang Zou
Summary: Rab11a is downregulated in breast cancer under hypoxia, promoting tumor cell migration and associated with changes in the expression of epithelial-mesenchymal transition-related proteins. Additionally, Rab11a levels are downregulated in the metastatic axillary lymph nodes of breast cancer patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.