Attenuation of STAT3 Signaling Cascade by Daidzin Can Enhance the Apoptotic Potential of Bortezomib against Multiple Myeloma

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

(2019) Chin-Yap Loh et al.   Frontiers in Oncology

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells

(2019) Sun Tae Hwang et al.   PHYTOMEDICINE

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

(2019) Chulwon Kim et al.   Biomolecules

Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways

(2019) Young Yun Jung et al.   MOLECULES

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Synergistic Effect of Bioactive Anticarcinogens from Soybean on Anti-Proliferative Activity in MDA-MB-231 and MCF-7 Human Breast Cancer Cells In Vitro

(2018) Yingying Zhu et al.   MOLECULES

Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea

(2018) Fan Xiao et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

(2018) Young Yun Jung et al.   Frontiers in Pharmacology

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

(2018) Muthu K. Shanmugam et al.   Frontiers in Pharmacology

Arctiin is a specific inhibitor of STAT3 phosphorylation in tyrosine 705 residue and potentiates bortezomib-induced apoptotic, proliferative, and angiogenetic effects in human multiple-myeloma cells

(2018) Jong Hyun Lee et al.   PHYTOMEDICINE

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

(2018) Loukik Arora et al.   Cancers

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade

(2018) Jong Hyun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

(2018) Matilda Lee et al.   Redox Biology

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

(2018) Jong Lee et al.   Cancers

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect

(2017) Gulce Sari Kaplan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades

(2017) Hanwool Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway

(2017) Jeong-Hyeon Ko et al.   MOLECULES

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

(2017) Seung Baek et al.   MOLECULES

Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro

(2017) Lalita Subedi et al.   Nutrients

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer

(2016) Jingwen Zhang et al.   APOPTOSIS

Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

(2016) Xiaoyun Dai et al.   MOLECULAR CANCER THERAPEUTICS

Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth

(2016) Kailee A. Johnson et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

(2016) Jessica L. Geiger et al.   ORAL ONCOLOGY

Targeting transcription factor STAT3 for cancer prevention and therapy

(2016) Edna Zhi Pei Chai et al.   PHARMACOLOGY & THERAPEUTICS

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

(2016) Seung Ho Baek et al.   PHYTOMEDICINE

Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases

(2016) Seung Ho Baek et al.   PHYTOTHERAPY RESEARCH

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

(2016) Jong Hyun Lee et al.   Oncotarget

IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future

(2015) Go Woon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway

(2015) Jong Hyun Lee et al.   CANCER LETTERS

Current therapeutic strategies for multiple myeloma

(2015) Yoshihiro Torimoto et al.   International Journal of Clinical Oncology

SHP-1 is a negative regulator of epithelial–mesenchymal transition in hepatocellular carcinoma

(2015) L-C Fan et al.   ONCOGENE

Preparation and application of a monoclonal antibody against the isoflavone glycoside daidzin using a mannich reaction-derived hapten conjugate

(2015) Gorawit Yusakul et al.   PHYTOCHEMICAL ANALYSIS

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model

(2015) Kodappully Sivaraman Siveen et al.   Oncotarget

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

(2015) Jahangir Abdi et al.   Oncotarget

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells

(2014) Sung-Moo Kim et al.   CANCER LETTERS

Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases

(2013) Jong Hyun Lee et al.   CANCER LETTERS

β-caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase

(2013) Chulwon Kim et al.   MOLECULAR CARCINOGENESIS

Bortezomib-induced severe autonomic neuropathy

(2012) A. Stratogianni et al.   CLINICAL AUTONOMIC RESEARCH

Thalidomide-induced acute cholestatic hepatitis: Case report and review of the literature

(2012) Filipe Vilas-Boas et al.   Gastroenterologia y Hepatologia

Pathogenesis of Myeloma

(2011) Kenneth C. Anderson et al.   Annual Review of Pathology-Mechanisms of Disease

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies

(2010) N. Reddy et al.   ANNALS OF ONCOLOGY

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

(2010) Feng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

(2009) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS