Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Oncology
Ranzhiqiang Yang, Yinghui Song, Kashif Shakoor, Weimin Yi, Chuang Peng, Sulai Liu
Summary: Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumor with a poor prognosis, characterized by neoplastic transformation of intrahepatic biliary epithelial cells. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that may serve as a target for ICC treatment. Further research is needed to improve understanding of STAT3 and its role in ICC development.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Geriatrics & Gerontology
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Keunwan Park, Chan Hee Lee, Kae Won Cho, Yun Kyung Lee, Jae-Young Lim, Jeong Kyo Yoon, Sae Hwan Lee, Hyog Young Kwon
Summary: Ginsenoside Rd (GRd) significantly ameliorates muscle wasting induced by aging and cancer through various mechanisms, demonstrating a potential therapeutic role in reversing muscle wasting in mice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jingyi Feng, Zijing Huang, Jiarui Lu, Laiting Chan, Xin Feng, Lizhen Lei, Zhuwei Huang, Lichieh Lin, Yichen Yao, Xiaolei Zhang
Summary: This study aimed to investigate the effect of Stat3 on osteoblast-mediated bone healing in inflammatory lesions. Conditional knockout of Stat3 in osteoblasts resulted in decreased bone mass and increased osteolysis in the inflammatory lesions. Stat3-deficient osteoblasts showed impaired calcium deposits, decreased expression of osteogenic markers, and increased expression of RANKL. Moreover, Stat3-deficient osteoblasts exhibited decreased proliferation and migration in response to LPS stimulation.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: The study found that IL-10 promotes fibrosis in endometriosis instead of having an anti-fibrotic effect. Inhibition of STAT3 gene activation can reduce the pro-fibrotic phenotype induced by IL-10 in endometriotic stromal cells.
HUMAN REPRODUCTION
(2023)
Article
Oncology
Xiaodong Wang, Xiaoji Ding, Jin Yan, Ziying Lu, Haoyang Cao, Xiaolong Ni, Yin Ying
Summary: The study showed that inhibiting STAT5 significantly reduced atherosclerosis induced by high-fat diet and decreased inflammation. Furthermore, targeting STAT5 could also reduce inflammation induced by oxLDL.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Biqiang Zhu, Jingjing Zheng, Gaichao Hong, Tao Bai, Wei Qian, Jinsong Liu, Xiaohua Hou
Summary: L-fucose inhibits the progression of CCA through the miR-200b/MAPK7 and signal transducer and activator of transcription 3 signaling pathways.
CHINESE MEDICAL JOURNAL
(2022)
Article
Chemistry, Medicinal
Ko-Hua Yu, Chin-Chuan Hung, Tian-Shung Wu, Chin-Fu Chen, I-Ting Wu, Ping-Chung Kuo, Sio-Hong Lam, Hsin-Yi Hung
Summary: Research has shown that zhankuic acid methyl ester derivatives have better chemoreversal activity in multidrug-resistant cancer cells, with compound 12 exhibiting the highest reversal fold. Compounds 8, 12, and 26 were found to influence the activation of STAT3, contributing to their chemoreversal effects. These findings suggest a new potential combined therapy with paclitaxel for treating multidrug-resistant cancers.
Article
Endocrinology & Metabolism
An-Ci Siao, Li-Jane Shih, Yen-Yue Lin, Yi-Wei Tsuei, Yow-Chii Kuo, Hui-Chen Ku, Chih-Ping Chuu, Po-Jen Hsiao, Yung-Hsi Kao
Summary: ET-3 stimulates white preadipocyte growth through the ETAR, AMPK, JNK/c-JUN, and STAT3 pathways, showing a preadipocyte type-dependent effect. These findings provide insights into how endothelin mediates fat cell activity and associated diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah M. M. AL-Qabbaa, Samaher I. I. Qaboli, Tahani K. K. Alshammari, Maha A. A. Alamin, Haya M. M. Alrajeh, Lama A. A. Almuthnabi, Rana R. R. Alotaibi, Asma S. S. Alonazi, Anfal F. F. Bin Dayel, Nawal M. M. Alrasheed, Nouf M. M. Alrasheed
Summary: This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on diabetic nephropathy (DN). The results showed that sitagliptin can reduce inflammation and improve DN by inhibiting PTP1B and modulating the JAK/STAT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Zheng-nan Ren, Jun Yang, Meng-ya Zhang, Yi-wen Huang, Dong-xiao Song, Xun Sun, Li-long Pan, Jia Sun
Summary: This study demonstrated that (R)-TML104 alleviates experimental pancreatitis by activating AMP-activated protein kinase and inducing SIRT1 expression, which in turn reduces inflammatory cell infiltration. The mechanism involves inhibition of the inflammatory response mediated by the interleukin 6-STAT3 pathway through modulation of SIRT1.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Wijdan Al-Ahmadi, Thomas S. Webberley, Alex Joseph, Ffion Harris, Yee-Hung Chan, Reem Alotibi, Jessica O. Williams, Alaa Alahmadi, Thomas Decker, Timothy R. Hughes, Dipak P. Ramji
Summary: The study revealed significant impacts of ERK1 deficiency and STAT1 S727A modification on gene expression in macrophages, as well as key processes like inflammation and cell migration. These findings suggest potential therapeutic implications for the regulation of atherosclerosis.
Article
Oncology
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen, Mingyao Liu, Zhengfang Yi
Summary: This study identifies a novel drug called WB436B as a selective STAT3 inhibitor for the treatment of pancreatic cancer. WB436B effectively inhibits tumor growth and metastasis, providing hope for the treatment of pancreatic cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Medicinal
Marta Gargantilla, Leentje Persoons, Tereza Kauerova, Natalia del Rio, Dirk Daelemans, Eva-Maria Priego, Peter Kollar, Maria-Jesus Perez-Perez
Summary: This study identified new salicylanilide compounds with antiproliferative activity against cancer cells by inhibiting tubulin polymerization and STAT3 phosphorylation, without toxicity towards normal cells.
Article
Oncology
Supak Yothaisong, Malinee Thanee, Nisana Namwat, Puangrat Yongvanit, Thidarut Boonmars, Anucha Puapairoj, Watcharin Loilome
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2014)
Article
Oncology
Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang, Bandit Thinkhamrop
Article
Oncology
Wareeporn Wattanawongdon, Chariya Hahnvajanawong, Nisana Namwat, Sirimas Kanchanawat, Thidarut Boonmars, Patcharee Jearanaikoon, Chanwit Leelayuwat, Anchalee Techasen, Wunchana Seubwai
INTERNATIONAL JOURNAL OF ONCOLOGY
(2015)
Article
Oncology
Pakkayanee Sudsarn, Thidarut Boonmars, Wipaporn Ruangjirachuporn, Nisana Namwat, Watcharin Loilome, Pranee Sriraj, Ratchadawan Aukkanimart, Wonkchalee Nadchanan, Songsri Jiraporn
PATHOLOGY & ONCOLOGY RESEARCH
(2016)
Article
Biotechnology & Applied Microbiology
Minerva Daya, Watcharin Loilome, Anchalee Techasen, Malinee Thanee, Prakasit Sa-Ngiamwibool, Attapol Titapun, Puangrat Yongvanit, Nisana Namwat
ONCOTARGETS AND THERAPY
(2018)
Article
Gastroenterology & Hepatology
Runglawan Silakit, Watcharin Loilome, Puangrat Yongvanit, Porncheera Chusorn, Anchalee Techasen, Thidarut Boonmars, Narong Khuntikeo, Nittaya Chamadol, Chawalit Pairojkul, Nisana Namwat
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Kassaporn Duangkumpha, Anucha Puapairoj, Hideyuki Saya, Puangrat Yongvanit
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2014)
Article
Oncology
Walaiporn Khansaard, Anchalee Techasen, Nisana Namwat, Puangrat Yongvanit, Narong Khuntikeo, Anucha Puapairoj, Watcharin Loilome
Article
Oncology
Jurairat Jongthawin, Porncheera Chusorn, Anchalee Techasen, Watcharin Loilome, Thidarut Boonmars, Raynoo Thanan, Anucha Puapairoj, Narong Khuntikeo, Wichittra Tassaneeyakul, Puangrat Yongvanit, Nisana Namwat
Article
Biotechnology & Applied Microbiology
Sasikamon Khophai, Malinee Thanee, Anchalee Techasen, Nisana Namwat, Poramate Klanrit, Attapol Titapun, Apiwat Jarearnrat, Prakasit Sa-Ngiamwibool, Watcharin Loilome
ONCOTARGETS AND THERAPY
(2018)
Article
Oncology
Suyanee Thongchot, Chiara Vidoni, Alessandra Ferraresi, Watcharin Loilome, Narong Khuntikeo, Sakkarn Sangkhamanon, Attapol Titapun, Ciro Isidoro, Nisana Namwat
Summary: The study validates the hypothesis that CAF infiltration and IL-6 release predict poor prognosis in CCA patients, with low stromal IL-6 and active autophagy in cancer cells correlating with better outcomes and chemotherapy response. Therapeutic strategies targeting these factors may improve survival in CCA patients.
Article
Biochemistry & Molecular Biology
Bundit Promraksa, Praewpan Katrun, Jutarop Phetcharaburanin, Yingpinyapat Kittirat, Nisana Namwat, Anchalee Techasen, Jia V. Li, Watcharin Loilome
Summary: The study demonstrated that CA can induce apoptosis in CCA cells and may serve as a potent anticancer agent for CCA treatment. CA affects the half-inhibitory concentration of CCA cells and cellular metabolism, involving antioxidant defense mechanism, glycerophospholipid metabolism, and the tricarboxylic acid cycle.
Article
Medicine, General & Internal
Preawwalee Wintachai, Jing Quan Lim, Anchalee Techasen, Worachart Lert-Itthiporn, Sarinya Kongpetch, Watcharin Loilome, Jarin Chindaprasirt, Attapol Titapun, Nisana Namwat, Narong Khuntikeo, Apinya Jusakul
Summary: The study found that cfDNA levels were significantly higher in CCA compared to benign biliary disease and normal controls. cfDNA levels showed superior diagnostic efficacy in discriminating CCA from healthy controls and BBD.
Article
Multidisciplinary Sciences
Rujikorn Treeriya, Phuc N. Ho, Attapol Titapun, Poramate Klanrit, Manida Suksawat, Thanaporn Kulthawatsiri, Suphasarang Sirirattanakul, Watcharin Loilome, Nisana Namwat, Arporn Wangwiwatsin, Nittaya Chamadol, Narong Khuntikeo, Jutarop Phetcharaburanin
Summary: In this study, nuclear magnetic resonance (NMR) metabolomics was used to investigate the fecal metabolic phenotypes of different study groups, including normal bile duct, periductal fibrosis (PDF), and cholangiocarcinoma (CCA) patients. The results revealed distinct fecal metabolic patterns in PDF and CCA patients compared to the normal bile duct group, indicating the involvement of various metabolic pathways in PDF and CCA progression. The study also highlighted the role of gut-microbial host metabolic crosstalk in PDF and/or CCA patients.