Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study

Chemosensitization of hepatocellular carcinoma cells to sorafenib by β-caryophyllene oxide-induced inhibition of ABC export pumps

(2019) Silvia Di Giacomo et al.   ARCHIVES OF TOXICOLOGY

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience

(2019) Cem Simsek et al.   Journal of Oncology

Caryophyllene Sesquiterpenes from Pulicaria vulgaris Gaertn .: Isolation, Structure Determination, Bioactivity and Structure−Activity Relationship

(2019) Afifa Zardi-Bergaoui et al.   CHEMISTRY & BIODIVERSITY

STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells

(2019) Rossana Cocchiola et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines

(2019) Tânia Capelôa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

(2019) Ilse R. Dubbelboer et al.   Cancers

Dietary administration of β-caryophyllene and its epoxide to Sprague-Dawley rats for 90 days

(2019) Maria Bastaki et al.   FOOD AND CHEMICAL TOXICOLOGY

β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice

(2019) Paulina Chávez-Hurtado et al.   JOURNAL OF MEDICINAL FOOD

Volatiles of Black Pepper Fruits (Piper nigrum L.)

(2019) Dosoky et al.   MOLECULES

β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway – An in-vitro and in-silico study

(2019) Duraisamy Ramachandhiran et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Role of lactoferrin and its receptors on biliary epithelium

(2018) Romina Mancinelli et al.   BIOMETALS

Natural compounds and combination therapy in colorectal cancer treatment

(2018) A. Rejhová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caryophyllane sesquiterpenes inhibit DNA-damage by tobacco smoke in bacterial and mammalian cells

(2018) Silvia Di Giacomo et al.   FOOD AND CHEMICAL TOXICOLOGY

A crystallographic and theoretical study of an (E)-2-Hydroxyiminoethanone derivative: prediction of cyclooxygenase inhibition selectivity of stilbenoids by MM-PBSA and the role of atomic charge

(2018) Seyed Sajad Hosseini Balef et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular bases of the poor response of liver cancer to chemotherapy

(2018) Jose J.G. Marin et al.   Clinics and Research in Hepatology and Gastroenterology

Gambogenic acid reverses P-glycoprotein mediated multidrug resistance in HepG2/Adr cells and its underlying mechanism

(2018) Qianqian Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro and in silico evaluation of P-glycoprotein inhibition through 99m Tc-methoxyisobutylisonitrile uptake

(2018) Seyed Sajad Hosseini Balef et al.   Chemical Biology & Drug Design

Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

(2018) Gokhan Zengin et al.   MOLECULES

SPC Liposomes as Possible Delivery Systems for Improving Bioavailability of the Natural Sesquiterpene β-Caryophyllene: Lamellarity and Drug-Loading as Key Features for a Rational Drug Delivery Design

(2018) Antonella Di Sotto et al.   Pharmaceutics

Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation

(2017) Antonella Di Sotto et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition

(2017) Saikat Dewanjee et al.   MOLECULES

Combinatorial immunotherapy strategies for hepatocellular carcinoma

(2016) Maria Tagliamonte et al.   CURRENT OPINION IN IMMUNOLOGY

Drug combination therapy increases successful drug repositioning

(2016) Wei Sun et al.   DRUG DISCOVERY TODAY

The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice

(2016) Nan Wu et al.   HEPATOLOGY

β-caryophyllene andβ-caryophyllene oxide-natural compounds of anticancer and analgesic properties

(2016) Klaudyna Fidyt et al.   Cancer Medicine

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein

(2015) Chiara Riganti et al.   CANCER LETTERS

β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet–induced obese C57BL/6N mice

(2015) Jae In Jung et al.   CARCINOGENESIS

Mutagenicity of cigarette butt waste in the bacterial reverse mutation assay: The protective effects of β-caryophyllene and β-caryophyllene oxide

(2015) Silvia Di Giacomo et al.   ENVIRONMENTAL TOXICOLOGY

Interaction of β-caryophyllene and β-caryophyllene oxide with phospholipid bilayers: Differential scanning calorimetry study

(2015) Maria Grazia Sarpietro et al.   THERMOCHIMICA ACTA

Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells

(2015) Shaymaa M. M. Yahya et al.   TUMOR BIOLOGY

A caryophyllane-type sesquiterpene, caryophyllenol A from Valeriana amurensis

(2014) Junkai Wu et al.   FITOTERAPIA

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma

(2014) Takuji Torimura et al.   Translational Oncology

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products

(2013) Chulwon Kim et al.   APOPTOSIS

β-caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase

(2013) Chulwon Kim et al.   MOLECULAR CARCINOGENESIS

Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P-glycoprotein expression

(2013) LI SUN et al.   Molecular Medicine Reports

Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells

(2013) Safaa Yehia Eid et al.   PHYTOMEDICINE

Genotoxicity assessment of β-caryophyllene oxide

(2013) Antonella Di Sotto et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Safety and efficacy of metronomic non-pegylated liposomal encapsulated doxorubicin in heavily pretreated advanced breast cancer patients

(2012) L. Manso et al.   Clinical & Translational Oncology

The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin

(2012) Ji-Eon Kim et al.   XENOBIOTICA

Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer

(2011) Silvia Dellapasqua et al.   BREAST

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

(2011) Veronika Hanušová et al.   DRUG METABOLISM REVIEWS

The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

(2011) Naseem Akhtar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp

(2011) Xulong Zhang et al.   PLoS One

Galactosylated α,β-poly[(2-hydroxyethyl)-L-aspartamide]-bound doxorubicin

(2010) Xiaoyun Cheng et al.   ANTI-CANCER DRUGS

Role of STAT3 decoy oligodeoxynucleotides on cell invasion and chemosensitivity in human epithelial ovarian cancer cells

(2010) Xiaolei Zhang et al.   CANCER GENETICS AND CYTOGENETICS

Inhibition by β-caryophyllene of ethyl methanesulfonate-induced clastogenicity in cultured human lymphocytes

(2010) Antonella Di Sotto et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Metronomic administration of pegylated liposomal-doxorubicin in extensively pre-treated metastatic breast cancer patients: A mono-institutional case-series report

(2009) E. Munzone et al.   BREAST

Chemical composition and antibacterial activity of essential oils of Eugenia species

(2009) Michele D. A. Magina et al.   Journal of Natural Medicines

Interaction of the P-Glycoprotein Multidrug Efflux Pump with Cholesterol: Effects on ATPase Activity, Drug Binding and Transport†

(2008) Paul D. W. Eckford et al.   BIOCHEMISTRY

Evolutionary Advantage and Molecular Modes of Action of Multi-Component Mixtures Used in Phytomedicine

(2008) Michael Wink   CURRENT DRUG METABOLISM

Antimutagenic and mutagenic activities of some terpenes in the bacterial reverse mutation assay

(2008) Antonella Di Sotto et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA