Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

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Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells

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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

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Rapamycin decelerates cellular senescence

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Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner

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Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

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Targeting lysosomes to eradicate imatinib-resistant chronic myelogenous leukemia cells

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Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells

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Autophagy facilitates oncogene-induced senescence

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Modulation of Caspase-Independent Cell Death Leads to Resensitization of Imatinib Mesylate-Resistant Cells

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Cellular senescence: Its role in tumor suppression and aging

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Life and death partners: apoptosis, autophagy and the cross-talk between them

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Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

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Eating to exit: autophagy-enabled senescence revealed

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Autophagy mediates the mitotic senescence transition

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Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR–ABL cleavage and elimination of chronic myelogenous leukemia cells

(2009) A Puissant et al.   LEUKEMIA

Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression

(2008) F.-X. Mahon et al.   CANCER RESEARCH

Imatinib Mesylate Induces Quiescence in Gastrointestinal Stromal Tumor Cells through the CDH1-SKP2-p27Kip1Signaling Axis

(2008) Ying Liu et al.   CANCER RESEARCH

Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

(2008) Melissa M. Dix et al.   CELL

Does autophagy have a license to kill mammalian cells?

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION

TAF6δ Controls Apoptosis and Gene Expression in the Absence of p53

(2008) Emmanuelle Wilhelm et al.   PLoS One

Proteomic analysis of an imatinib-resistant K562 cell line highlights opposing roles of heat shock cognate 70 and heat shock 70 proteins in resistance

(2008) Marion Pocaly et al.   PROTEOMICS