Effects of senolytic drugs on human mesenchymal stromal cells

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells

(2017) Eduardo Fernandez-Rebollo et al.   Scientific Reports

Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence

(2017) Nicola Alessio et al.   NEOPLASIA

Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells

(2016) Julia Franzen et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

Danazol Treatment for Telomere Diseases

(2016) Danielle M. Townsley et al.   NEW ENGLAND JOURNAL OF MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Danazol induces apoptosis and cytotoxicity of leukemic cells alone and in combination with purine nucleoside analogs in chronic lymphocytic leukemia

(2015) Monika Podhorecka et al.   ANNALS OF HEMATOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

(2011) Carmen M. Koch et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Impact of individual platelet lysates on isolation and growth of human mesenchymal stromal cells

(2010) Patrick Horn et al.   CYTOTHERAPY

Anti-ageing and rejuvenating effects of quercetin

(2010) Niki Chondrogianni et al.   EXPERIMENTAL GERONTOLOGY

Different Facets of Aging in Human Mesenchymal Stem Cells

(2010) Wolfgang Wagner et al.   TISSUE ENGINEERING PART B-REVIEWS

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One