Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

Repeated immune activation with low-dose lipopolysaccharide attenuates the severity of Huntington's disease in R6/2 transgenic mice

(2018) Sung Won Lee et al.   Animal Cells and Systems

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson’s disease

(2018) Yi-Ying Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Differential effects of lipopolysaccharide on mouse sensory TRP channels

(2018) Brett Boonen et al.   CELL CALCIUM

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Rosiglitazone as a Modulator of TLR4 and TLR3 Signaling Pathways in Rat Primary Neurons and Astrocytes

(2018) Dmitry Chistyakov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration

(2018) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

Inflammation, Immunity and ALS: Etiology and Pathology

(2018) Miles Lyon et al.   MUSCLE & NERVE

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

(2018) Yazmin M. Flores-Martinez et al.   Journal of Immunology Research

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease

(2018) Yong-Fei Zhao et al.   Aging and Disease

Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model

(2018) Shawn M. Barton et al.   JOURNAL OF ALZHEIMERS DISEASE

Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease

(2018) Camilla Thygesen et al.   Frontiers in Cellular Neuroscience

Role of Microglia TLRs in Neurodegeneration

(2018) Bernd L. Fiebich et al.   Frontiers in Cellular Neuroscience

P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo

(2018) Chao Gu et al.   Frontiers in Cellular Neuroscience

Activation of EP2 receptor suppresses poly(I: C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs

(2017) Nizar M. Yousif et al.   GLIA

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide

(2017) Eric E. Beier et al.   NEUROBIOLOGY OF DISEASE

Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway

(2017) Randy Hunter et al.   NEUROSCIENCE RESEARCH

Genetic Forms of Parkinson's Disease

(2017) Christine Kim et al.   SEMINARS IN NEUROLOGY

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

(2017) Yeranddy A. Alpizar et al.   Nature Communications

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

(2017) Jia Liu et al.   Frontiers in Immunology

Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain

(2017) Yuhai Zhao et al.   Frontiers in Immunology

Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection

(2017) Neha Sharma et al.   INFLAMMOPHARMACOLOGY

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes1

(2017) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

(2017) Harsharan S. Bhatia et al.   Scientific Reports

Apocyanin, NADPH oxidase inhibitor prevents lipopolysaccharide induced α-synuclein aggregation and ameliorates motor function deficits in rats: Possible role of biochemical and inflammatory alterations

(2016) Neha Sharma et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration

(2016) Li Ma et al.   BRAIN RESEARCH BULLETIN

Synucleinopathies: common features and hippocampal manifestations

(2016) Weiwei Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparative morphometric analysis of microglia in the spinal cord of SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2016) Tomohiro Ohgomori et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

LRRK2 modulates microglial activity through regulation of chemokine (C–X3–C) receptor 1 –mediated signalling pathways

(2016) Bo Ma et al.   HUMAN MOLECULAR GENETICS

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease

(2016) Ingrid H. Philippens et al.   JOURNAL OF ALZHEIMERS DISEASE

All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats

(2016) Nassima Behairi et al.   JOURNAL OF NEUROIMMUNOLOGY

Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation

(2016) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

(2016) Richard Gordon et al.   NEUROBIOLOGY OF DISEASE

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches

(2016) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain

(2016) Olena Lykhmus et al.   Frontiers in Molecular Neuroscience

Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice

(2016) Chia-Hung Chien et al.   PLoS One

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

(2016) Changyoun Kim et al.   Scientific Reports

Interleukin-10 Protection against Lipopolysaccharide-Induced Neuro-Inflammation and Neurotoxicity in Ventral Mesencephalic Cultures

(2015) Yan Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson’s Disease Model

(2015) Neha Sharma et al.   MOLECULAR NEUROBIOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

α7 Nicotinic Acetylcholine Receptor-Specific Antibody Induces Inflammation and Amyloid β42 Accumulation in the Mouse Brain to Impair Memory

(2015) Olena Lykhmus et al.   PLoS One

Inflammation Induces TDP-43 Mislocalization and Aggregation

(2015) Ana Sofia Correia et al.   PLoS One

Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: Modulation by NOS inhibitors

(2014) Ahmed Maher et al.   BRAIN RESEARCH BULLETIN

Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling

(2014) Julie Cazareth et al.   Journal of Neuroinflammation

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Morphine Prevents Lipopolysaccharide-Induced TNF Secretion in Mast Cells Blocking I B Kinase Activation and SNAP-23 Phosphorylation: Correlation with the Formation of a  -Arrestin/TRAF6 Complex

(2013) I. K. Madera-Salcedo et al.   JOURNAL OF IMMUNOLOGY

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

(2013) Arnaud François et al.   Journal of Neuroinflammation

CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression

(2013) Tony Valente et al.   NEUROBIOLOGY OF AGING

Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem

(2013) Isabelle Bardou et al.   NEUROBIOLOGY OF AGING

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

(2013) Adam Jangula et al.   NEUROSCIENCE LETTERS

Autophagic Impairment Contributes to Systemic Inflammation-Induced Dopaminergic Neuron Loss in the Midbrain

(2013) Hui-Fen Zheng et al.   PLoS One

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice

(2012) Toshihiko Katafuchi et al.   Annals of the New York Academy of Sciences

Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood–brain barrier: Protection by the antioxidant N-acetylcysteine

(2012) Michelle A. Erickson et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18

(2012) Paola Bossù et al.   Journal of Neuroinflammation

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

(2012) Sophie Leow-Dyke et al.   Journal of Neuroinflammation

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease

(2012) J. Bouchard et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Common variation in theLRRK2gene is a risk factor for Parkinson's disease

(2012) Ignacio F. Mata et al.   MOVEMENT DISORDERS

The Parkinson's disease-related genes act in mitochondrial homeostasis

(2012) Yan Sai et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Lipopolysaccharide-induced tau phosphorylation and kinase activity - modulation, but not mediation, by corticotropin-releasing factor receptors

(2011) Allyson D. Roe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Myeloid Differentiation Factor-2 Interacts with Lyn Kinase and Is Tyrosine Phosphorylated Following Lipopolysaccharide-Induced Activation of the TLR4 Signaling Pathway

(2011) Pearl Gray et al.   JOURNAL OF IMMUNOLOGY

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration

(2011) Keke Zhang   Molecular Medicine Reports

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

(2011) Sonia Franciosi et al.   NEUROBIOLOGY OF DISEASE

Switching the Microglial Harmful Phenotype Promotes Lifelong Restoration of Subtantia Nigra Dopaminergic Neurons from Inflammatory Neurodegeneration in Aged Mice

(2011) Francesca L'Episcopo et al.   REJUVENATION RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) S. Byrne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Inhibition of I B Kinase-  Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity

(2010) F. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulusEvidence in Parkinson's disease patients

(2010) M.A. Burguillos et al.   NEUROBIOLOGY OF DISEASE

Inflammation in Neurological Disorders: A Help or a Hindrance?

(2010) V. Wee Yong   NEUROSCIENTIST

Impairment of long-term depression induced by chronic brain inflammation in rats

(2009) Sun Seek Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Distinct neuroinflammatory profile in post-mortem human Huntingtonʼs disease

(2009) Aurelio Silvestroni et al.   NEUROREPORT

Striatal Neuroinflammation Promotes Parkinsonism in Rats

(2009) Dong-Young Choi et al.   PLoS One

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease

(2008) Tarja M. Malm et al.   GLIA

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

(2008) Maria Björkqvist et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration

(2008) Emily N. Mangano et al.   NEUROBIOLOGY OF AGING

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

(2008) Yuxin Liu et al.   NEUROTOXICOLOGY

Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons

(2007) Cristian Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague–Dawley rats

(2007) Randy L. Hunter et al.   NEUROSCIENCE LETTERS