Mechanistic Insight into Heptosyltransferase Inhibition by using Kdo Multivalent Glycoclusters

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition

(2016) Marta Abellán Flos et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pillar[5]arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins

(2016) Kevin Buffet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

(2016) Mathieu L. Lepage et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases

(2015) Nadia Touisni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold

(2015) Stéphane P. Vincent et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

(2015) Kevin Buffet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold

(2015) Marta Abellán-Flos et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthetic multivalency for biological applications

(2015) Eugene Mahon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Emerging trends in enzyme inhibition by multivalent nanoconstructs

(2015) Nasreddine Kanfar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

(2014) Sébastien G. Gouin   CHEMISTRY-A EUROPEAN JOURNAL

Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases

(2014) Lauren Tedaldi et al.   MedChemComm

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mannosylated pillar[5]arene derivative: chiral information transfer and antiadhesive properties against uropathogenic bacteria

(2013) Iwona Nierengarten et al.   TETRAHEDRON LETTERS

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of a small library of bivalent α-d-mannopyranosides for lectin cross-linking

(2011) Milan Bergeron-Brlek et al.   CARBOHYDRATE RESEARCH

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Systematic Synthesis of Inhibitors of the Two First Enzymes of the Bacterial Heptose Biosynthetic Pathway: Towards Antivirulence Molecules Targeting Lipopolysaccharide Biosynthesis

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

(2010) Macarena Sánchez-Navarro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Glycal Fluorophosphorylation: Synthesis of ADP-2-fluoroheptose, an Inhibitor of the LPS Biosynthesis

(2008) Hirofumi Dohi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

(2008) Maamar Stiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY