Exploring carbonic anhydrase inhibition with multimeric coumarins displayed on a fullerene scaffold

Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes

(2015) Yoan Brissonnet et al.   BIOCONJUGATE CHEMISTRY

Out of the active site binding pocket for carbonic anhydrase inhibitors

(2015) Katia D'Ambrosio et al.   CHEMICAL COMMUNICATIONS

New coumarin-[60]fullerene dyads connected by an alkynyl linkage: Synthesis and fluorescence studies. Evidence for efficient singlet–singlet energy transfer

(2015) Susana Nascimento et al.   DYES AND PIGMENTS

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

(2014) Colin Bonduelle et al.   CHEMICAL COMMUNICATIONS

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

(2014) Amine M. Boukerb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multivalent glycosylated nanoparticles for studying carbohydrate–protein interactions

(2014) Avijit K. Adak et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycofullerenes Inhibit Viral Infection

(2013) Joanna Luczkowiak et al.   BIOMACROMOLECULES

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Multivalent scaffolds in glycoscience: an overview

(2013) Olivier Renaudet et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX

(2013) Aditi Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mannosylated pillar[5]arene derivative: chiral information transfer and antiadhesive properties against uropathogenic bacteria

(2013) Iwona Nierengarten et al.   TETRAHEDRON LETTERS

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

(2012) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibition of bacterial adhesion to live human cells: Activity and cytotoxicity of synthetic mannosides

(2012) Mirja Hartmann et al.   FEBS LETTERS

Carbohydrate–protein interactions and their biosensing applications

(2011) Xiangqun Zeng et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Multivalent Glycoclusters from 1-Thio-β-d-galactose and Their Inhibitory Activity against the β-Galactosidase fromE. coli

(2011) Alejandro J. Cagnoni et al.   JOURNAL OF ORGANIC CHEMISTRY

Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications

(2011) Jean-Louis Reymond et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

(2010) Macarena Sánchez-Navarro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene-Coumarin Dyad as a Selective Metal Receptor: Synthesis, Photophysical Properties, Electrochemistry and Ion Binding Studies

(2010) Georgia Pagona et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule

(2010) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors

(2009) Claudia Temperini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Research Highlights

(2009) R Banerjee   Nanomedicine

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adducts

(2008) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions

(2008) Isao Nishimori et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

(2008) Maamar Stiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY