Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases

Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG

(2013) Paul A. Mann et al.   ACS Chemical Biology

Selective inhibition of glycosyltransferases by bivalent imidazolium salts

(2013) Yin Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of fucosyltransferase and fucosidase inhibitors

(2013) Zhijay Tu et al.   CHEMICAL SOCIETY REVIEWS

Design of Glycosyltransferase Inhibitors: Pyridine as a Pyrophosphate Surrogate

(2013) Shuai Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Base-modified Donor Analogues Reveal Novel Dynamic Features of a Glycosyltransferase

(2013) René Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nonionic Inhibitor with High Specificity for the UDP-Gal Donor Binding Site of Human Blood Group B Galactosyltransferase: Design, Synthesis, and Characterization

(2013) Katrin Schaefer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toward Analogues of MraY Natural Inhibitors: Synthesis of 5′-Triazole-Substituted-Aminoribosyl Uridines Through a Cu-Catalyzed Azide–Alkyne Cycloaddition

(2013) Mickaël J. Fer et al.   JOURNAL OF ORGANIC CHEMISTRY

C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–l-isoDMDP Compared to Miglitol and Miglustat

(2013) Sarah F. Jenkinson et al.   JOURNAL OF ORGANIC CHEMISTRY

A Glycosyltransferase Inhibitor from a Molecular Fragment Library Simultaneously Interferes with Metal Ion and Substrate Binding

(2012) Rene Jørgensen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sialic acid metabolism and sialyltransferases: natural functions and applications

(2012) Yanhong Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A New Concept for Glycosyltransferase Inhibitors: Nonionic Mimics of the Nucleotide Donor of the Human Blood Group B Galactosyltransferase

(2012) Katrin Schaefer et al.   CHEMBIOCHEM

Recent structures, evolution and mechanisms of glycosyltransferases

(2012) Christelle Breton et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

Miglustat as a therapeutic agent: prospects and caveats

(2012) Rosemarie E Venier et al.   JOURNAL OF MEDICAL GENETICS

Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase

(2012) Steven Richards et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

(2012) Laurence Boudière et al.   Molecular BioSystems

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase

(2011) Jiaoyang Jiang et al.   Nature Chemical Biology

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana

(2011) Cyrille Y Botté et al.   Nature Chemical Biology

A Glucosylceramide Synthase Inhibitor Protects Rats Against the Cytotoxic Effects of Shiga Toxin 2

(2011) CLAUDIA SILBERSTEIN et al.   PEDIATRIC RESEARCH

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

(2011) J. H. Reiling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosyltransferases and their Assays

(2010) Gerd K. Wagner et al.   CHEMBIOCHEM

A Novel Fluorescent Probe for Retaining Galactosyltransferases

(2010) Thomas Pesnot et al.   CHEMBIOCHEM

New structures, chemical functions, and inhibitors for glycosyltransferases

(2010) Rajarshi Roychoudhury et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The chemical biology of new drugs in the development for tuberculosis

(2010) Clifton E Barry et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments

(2010) Christoph Rademacher et al.   GLYCOCONJUGATE JOURNAL

Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma

(2010) J. Karman et al.   INTERNATIONAL IMMUNOLOGY

Safety, Tolerability, and Pharmacokinetics of Eliglustat Tartrate (Genz-112638) After Single Doses, Multiple Doses, and Food in Healthy Volunteers

(2010) M. Judith Peterschmitt et al.   JOURNAL OF CLINICAL PHARMACOLOGY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

UDP-(5F)-GlcNAc Acts as a Slow-Binding Inhibitor of MshA, a Retaining Glycosyltransferase

(2010) Patrick A. Frantom et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Exploring genomes for glycosyltransferases

(2010) Sara Fasmer Hansen et al.   Molecular BioSystems

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

(2010) Thomas Pesnot et al.   Nature Chemical Biology

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Identification and characterization of flavonoids as sialyltransferase inhibitors

(2009) Kazuya I.P.J. Hidari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness

(2009) Terry K. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rhodanine as a Privileged Scaffold in Drug Discovery

(2009) T. Tomasic et al.   CURRENT MEDICINAL CHEMISTRY

Bisubstrate Analogues as Glycosyltransferase Inhibitors

(2009) Masayuki Izumi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases

(2009) Hiroshi Hinou et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis of Glycosyltransferase Inhibitors

(2009) Tetsuya Kajimoto et al.   SYNTHESIS-STUTTGART

Design, synthesis, and evaluation of novel ethambutol analogues

(2008) Raghunandan Yendapally et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors

(2008) F. Moreau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Glycans in cancer progression

(2008) K. S Lau et al.   GLYCOBIOLOGY

Deoxygenated Disaccharide Analogs as Specific Inhibitors of β1–4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis

(2008) Jillian R. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

A Strategy to Discover Inhibitors of O-Linked Glycosylation

(2007) Benjamin J. Gross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY