Cellular Factors Targeting HIV-1 Transcription and Viral RNA Transcripts

Block-And-Lock Strategies to Cure HIV Infection

(2020) Gerlinde Vansant et al.   Viruses-Basel

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

(2020) Dorota Kmiec et al.   mBio

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

(2019) Xiancai Ma et al.   eLife

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Potential roles of Nef and Vpu in HIV-1 latency

(2019) Dorota Kmiec et al.   Future Virology

Characterization of novel splice variants of zinc finger antiviral protein (ZAP)

(2019) Melody M. H. Li et al.   JOURNAL OF VIROLOGY

Interferon-inducible TRIM22 contributes to maintenance of HIV-1 proviral latency in T cell lines

(2019) Filippo Turrini et al.   VIRUS RESEARCH

FOXO1 transcription factor plays a key role in T cell—HIV-1 interaction

(2019) Arthur Roux et al.   PLoS Pathogens

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

(2019) Daichi Yamasoba et al.   Nature Microbiology

HIV “shock and kill” therapy: In need of revision

(2019) Erik Abner et al.   ANTIVIRAL RESEARCH

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

(2019) Dominik Hotter et al.   Cell Host & Microbe

The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides

(2019) Valerie Odon et al.   NUCLEIC ACIDS RESEARCH

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

(2019) Mattia Ficarelli et al.   eLife

CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms

(2019) Mattia Ficarelli et al.   JOURNAL OF VIROLOGY

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

(2019) Johannes Schwerk et al.   NATURE IMMUNOLOGY

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

(2019) Jennifer L. Meagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

(2019) Paola Miyazato et al.   Retrovirology

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Novel host restriction factors implicated in HIV-1 replication

(2018) Dibya Ghimire et al.   JOURNAL OF GENERAL VIROLOGY

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies

(2018) Kaori Asamitsu et al.   MOLECULES

HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

(2018) Steven A. Yukl et al.   Science Translational Medicine

Barriers for HIV Cure: The Latent Reservoir

(2018) Sergio Castro-Gonzalez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact

(2018) Luis M. Agosto et al.   Cell Reports

HIV cure strategies: a complex approach for a complicated viral reservoir?

(2018) Matthew D Marsden et al.   Future Virology

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein

(2017) Xiaojiao Zheng et al.   JOURNAL OF VIROLOGY

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

(2017) Matthew A. Takata et al.   NATURE

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

(2017) Irati Antzin-Anduetza et al.   Retrovirology

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

(2017) Dominik Hotter et al.   PLoS Pathogens

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses

(2017) Rosalba Perrone et al.   Scientific Reports

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection

(2016) Benjamin A. Diner et al.   mBio

Residual inflammation and viral reservoirs

(2016) Marta Massanella et al.   Current Opinion in HIV and AIDS

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

(2016) Eleanor Gaunt et al.   eLife

IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation

(2016) Lucia Hároníková et al.   PLoS One

Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency

(2015) Guochun Jiang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Cooperative Assembly of IFI16 Filaments on dsDNA Provides Insights into Host Defense Strategy

(2015) Jungsan Sohn et al.   BIOPHYSICAL JOURNAL

SnapShot: Antiviral Restriction Factors

(2015) Silvia F. Kluge et al.   CELL

RNase L Activates the NLRP3 Inflammasome during Viral Infections

(2015) Arindam Chakrabarti et al.   Cell Host & Microbe

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

(2015) Irene Lo Cigno et al.   JOURNAL OF VIROLOGY

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

(2015) Filippo Turrini et al.   Retrovirology

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

(2015) Daniel Sauter et al.   Cell Reports

Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target

(2014) Stephen Safe et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RNase-L Control of Cellular mRNAs: Roles in Biologic Functions and Mechanisms of Substrate Targeting

(2014) Sarah E. Brennan-Laun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

(2014) Karen E. Johnson et al.   PLoS Pathogens

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells

(2013) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA

(2013) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNAS Plus: From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

(2013) M. R. Jakobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Selective Targeting of the Repressive Transcription Factors YY1 and cMyc to Disrupt Quiescent Human Immunodeficiency Viruses

(2012) Kirston Barton et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Restriction Factors of Human Immunodeficiency Virus

(2012) Reuben S. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple NF-κB Sites in HIV-1 Subtype C Long Terminal Repeat Confer Superior Magnitude of Transcription and Thereby the Enhanced Viral Predominance

(2012) Mahesh Bachu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells

(2012) Y. Xuan et al.   JOURNAL OF VIROLOGY

Shock and kill

(2012) Steven G. Deeks   NATURE

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

(2012) T. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF- B-Responsive Long Terminal Repeat Elements

(2011) A. Kajaste-Rudnitski et al.   JOURNAL OF VIROLOGY

New Insights into the Role of RNase L in Innate Immunity

(2010) Arindam Chakrabarti et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence

(2010) Jesper B. Andersen et al.   RNA Biology

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY

TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus

(2009) P. Eldin et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Inactivation of Poliovirus Infectivity by Increasing the Frequencies of CpG and UpA Dinucleotides within and across Synonymous Capsid Region Codons

(2009) C. C. Burns et al.   JOURNAL OF VIROLOGY

CGIN1: A Retroviral Contribution to Mammalian Genomes

(2009) A. Marco et al.   MOLECULAR BIOLOGY AND EVOLUTION

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of the Antiviral Kinase PKR and Viral Countermeasures

(2009) Bianca Dauber et al.   Viruses-Basel

RNase L Mediated Protection from Virus Induced Demyelination

(2009) Derek D. C. Ireland et al.   PLoS Pathogens

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein

(2008) Julie A. Kerns et al.   PLoS Genetics