The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides

Identified OAS3 gene variants associated with coexistence of HBsAg and anti-HBs in chronic HBV infection

(2018) S. Wang et al.   JOURNAL OF VIRAL HEPATITIS

Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein

(2018) Hsin-Ping Chiu et al.   PLoS Pathogens

Origin and development of oligoadenylate synthetase immune system

(2018) Jiaxiang Hu et al.   BMC EVOLUTIONARY BIOLOGY

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

(2018) Jacint G. Sanchez et al.   JOURNAL OF MOLECULAR BIOLOGY

Prisoners of war — host adaptation and its constraints on virus evolution

(2018) Peter Simmonds et al.   NATURE REVIEWS MICROBIOLOGY

TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein

(2017) Xiaojiao Zheng et al.   JOURNAL OF VIROLOGY

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

(2017) Matthew A. Takata et al.   NATURE

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

(2017) Irati Antzin-Anduetza et al.   Retrovirology

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

(2017) Jelke Jan Fros et al.   eLife

Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing

(2016) Jeroen Witteveldt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance

(2016) Xinlu Wang et al.   JOURNAL OF VIROLOGY

The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1

(2016) Qiannan Tang et al.   JOURNAL OF VIROLOGY

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

(2016) Wendy Ullmer et al.   Viruses-Basel

Codon Pair Bias Is a Direct Consequence of Dinucleotide Bias

(2016) Dusan Kunec et al.   Cell Reports

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

(2016) Eleanor Gaunt et al.   eLife

Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein

(2015) Tobias Karlberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reply to Simmonds et al.: Codon pair and dinucleotide bias have not been functionally distinguished

(2015) Bruce Futcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein

(2015) Chien-Hung Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3

(2015) Jesse Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of dengue (and other RNA viruses) with codon pair recoding can be explained by increased CpG/UpA dinucleotide frequencies: Table 1.

(2015) Peter Simmonds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of the influenza A virus NS1 protein in antiviral defense

(2015) Robert M Krug   Current Opinion in Virology

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

(2015) John B. Moldovan et al.   PLoS Genetics

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

(2015) John L. Goodier et al.   PLoS Genetics

Association of dengue virus infection susceptibility with polymorphisms of 2′-5′-oligoadenylate synthetase genes: a case–control study

(2014) Ramanathan Thamizhmani et al.   Brazilian Journal of Infectious Diseases

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

(2014) D. Ross-Thriepland et al.   JOURNAL OF GENERAL VIROLOGY

The 2'-5'-Oligoadenylate Synthetase 3 Enzyme Potently Synthesizes the 2'-5'-Oligoadenylates Required for RNase L Activation

(2014) M. S. Ibsen et al.   JOURNAL OF VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

(2014) C. Le Nouen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts

(2014) Matthew D. Daugherty et al.   PLoS Genetics

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

(2014) Fiona Tulloch et al.   eLife

Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses

(2013) Peter Simmonds et al.   BMC GENOMICS

Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection

(2013) K. Alagarasu et al.   INFECTION GENETICS AND EVOLUTION

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

(2013) J. Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

(2013) Richeng Mao et al.   PLoS Pathogens

Translational repression precedes and is required for ZAP-mediated mRNA decay

(2012) Yiping Zhu et al.   EMBO JOURNAL

Glycogen Synthase Kinase 3β (GSK3β) Modulates Antiviral Activity of Zinc-finger Antiviral Protein (ZAP)

(2012) Lin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZAP Inhibits Murine Gammaherpesvirus 68 ORF64 Expression and Is Antagonized by RTA

(2012) Y. Xuan et al.   JOURNAL OF VIROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA

(2012) Shoudeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variability in the 2′‐5′‐Oligoadenylate Synthetase Gene Cluster Is Associated with Human Predisposition to Tick‐Borne Encephalitis Virus–Induced Disease

(2010) Andrey V. Barkhash et al.   JOURNAL OF INFECTIOUS DISEASES

Poliovirus-Mediated Disruption of Cytoplasmic Processing Bodies

(2010) J. D. Dougherty et al.   JOURNAL OF VIROLOGY

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

2′-5′-Oligoadenylate synthetase is activated by a specific RNA sequence motif

(2009) Reinhard Kodym et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Regulation of Type I Interferon Production by Paramyxoviruses

(2009) Stephen Goodbourn et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Genetic Inactivation of Poliovirus Infectivity by Increasing the Frequencies of CpG and UpA Dinucleotides within and across Synonymous Capsid Region Codons

(2009) C. C. Burns et al.   JOURNAL OF VIROLOGY

CAIcal: A combined set of tools to assess codon usage adaptation

(2008) Pere Puigbò et al.   Biology Direct

Bioinformatic and Physical Characterizations of Genome-Scale Ordered RNA Structure in Mammalian RNA Viruses

(2008) M. Davis et al.   JOURNAL OF VIROLOGY

Colocalization of fluorescent markers in confocal microscope images of plant cells

(2008) Andrew P French et al.   Nature Protocols

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

(2008) M. U. Gack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY