Activation of the Antiviral Kinase PKR and Viral Countermeasures

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Translational insensitivity to potent activation of PKR by HCV IRES RNA

(2009) Takashi Shimoike et al.   ANTIVIRAL RESEARCH

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene Products

(2009) Cyril X. George et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

RNA Dimerization Promotes PKR Dimerization and Activation

(2009) Laurie A. Heinicke et al.   JOURNAL OF MOLECULAR BIOLOGY

Ebola Virus VP35 Antagonizes PKR Activity through Its C-Terminal Interferon Inhibitory Domain

(2009) M. Schumann et al.   JOURNAL OF VIROLOGY

Essential Role for either TRS1 or IRS1 in Human Cytomegalovirus Replication

(2009) E. E. Marshall et al.   JOURNAL OF VIROLOGY

Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKK  and TBK-1

(2009) K. C. Prins et al.   JOURNAL OF VIROLOGY

NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase

(2009) M. Habjan et al.   JOURNAL OF VIROLOGY

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA

(2009) S. Myong et al.   SCIENCE

Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery

(2009) Tsung-Hsien Chang et al.   PLoS Pathogens

The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex

(2009) Rocío Coloma et al.   PLoS Pathogens

P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection

(2009) Alan G. Goodman et al.   PLoS Pathogens

Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR

(2009) Bianca Dauber et al.   PLoS Pathogens

Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation

(2009) Tetsuro Ikegami et al.   PLoS Pathogens

Structural Mechanism of RNA Recognition by the RIG-I-like Receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNITY

Approaching the RNA ligand for RIG-I?

(2008) Martin Schlee et al.   IMMUNOLOGICAL REVIEWS

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Analysis of Influenza B Virus NS1 Protein Trafficking Reveals a Novel Interaction with Nuclear Speckle Domains

(2008) J. Schneider et al.   JOURNAL OF VIROLOGY

Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA

(2008) K. Takeuchi et al.   JOURNAL OF VIROLOGY

Binding and Relocalization of Protein Kinase R by Murine Cytomegalovirus

(2008) S. J. Child et al.   JOURNAL OF VIROLOGY

Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143

(2008) M. Budt et al.   JOURNAL OF VIROLOGY

Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus

(2008) A. L. Hartman et al.   JOURNAL OF VIROLOGY

Protein Kinase PKR Mediates the Apoptosis Induction and Growth Restriction Phenotypes of C Protein-Deficient Measles Virus

(2008) A. M. Toth et al.   JOURNAL OF VIROLOGY

Whole-Genome Expression Profiling Reveals That Inhibition of Host Innate Immune Response Pathways by Ebola Virus Can Be Reversed by a Single Amino Acid Change in the VP35 Protein

(2008) A. L. Hartman et al.   JOURNAL OF VIROLOGY

Cellular La Protein Shields Nonsegmented Negative-Strand RNA Viral Leader RNA from RIG-I and Enhances Virus Growth by Diverse Mechanisms

(2008) V. Bitko et al.   JOURNAL OF VIROLOGY

TRBP Control of PACT-Induced Phosphorylation of Protein Kinase R Is Reversed by Stress

(2008) A. Daher et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein kinase R reveals an evolutionary model for defeating viral mimicry

(2008) Nels C. Elde et al.   NATURE

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

(2008) Stefan Rothenburg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

(2008) Matthias Habjan et al.   PLoS One

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

(2008) S. R. Nallagatla et al.   RNA

The Role of PACT in Mediating Gene Induction, PKR Activation, and Apoptosis in Response to Diverse Stimuli

(2007) Joao T. Marques et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH