The Restriction Factors of Human Immunodeficiency Virus

Characterization of the Interface of the Bone Marrow Stromal Cell Antigen 2–Vpu Protein Complex via Computational Chemistry

(2012) Jinming Zhou et al.   BIOCHEMISTRY

Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein

(2012) Nadine Laguette et al.   Cell Host & Microbe

The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx

(2012) Efrem S. Lim et al.   Cell Host & Microbe

The Host Restriction Factor APOBEC3G and Retroviral Vif Protein Coevolve due to Ongoing Genetic Conflict

(2012) Alex A. Compton et al.   Cell Host & Microbe

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest

(2012) Wei Wei et al.   CELLULAR MICROBIOLOGY

Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain

(2012) Jean K. Gustin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

(2012) Baek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

(2012) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor

(2012) Chiyu Zhang et al.   PLoS One

The role of tripartite motif family members in mediating susceptibility to HIV-1 infection

(2012) Nadia Rahm et al.   Current Opinion in HIV and AIDS

Endogenous Origins of HIV-1 G-to-A Hypermutation and Restriction in the Nonpermissive T Cell Line CEM2n

(2012) Eric W. Refsland et al.   PLoS Pathogens

Hiding in Plain Sight: How HIV Evades Innate Immune Responses

(2011) Nicolas Manel et al.   CELL

Compensatory Changes in the Cytoplasmic Tail of gp41 Confer Resistance to Tetherin/BST-2 in a Pathogenic Nef-Deleted SIV

(2011) Ruth Serra-Moreno et al.   Cell Host & Microbe

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein fromEnterococcus faecalisand Crystal Structure of the Activator-Substrate Complex

(2011) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

(2011) Mark Skasko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Role of the Endocytic Pathway in the Counteraction of BST-2 by Human Lentiviral Pathogens

(2011) D. Lau et al.   JOURNAL OF VIROLOGY

Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 Activity

(2011) X. Wang et al.   JOURNAL OF VIROLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

(2011) Hanna-Mari Tervo et al.   Retrovirology

HIV-1 Vpu Antagonizes BST-2 by Interfering Mainly with the Trafficking of Newly Synthesized BST-2 to the Cell Surface

(2011) Mathieu Dubé et al.   TRAFFIC

HIV-1 Vpu Blocks Recycling and Biosynthetic Transport of the Intrinsic Immunity Factor CD317/Tetherin To Overcome the Virion Release Restriction

(2011) S. Schmidt et al.   mBio

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release

(2011) Fengwen Zhang et al.   PLoS Pathogens

The ESCRT-0 Component HRS is Required for HIV-1 Vpu-Mediated BST-2/Tetherin Down-Regulation

(2011) Katy Janvier et al.   PLoS Pathogens

Rab7A Is Required for Efficient Production of Infectious HIV-1

(2011) Marina Caillet et al.   PLoS Pathogens

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligase

(2010) Laurieann Casey et al.   CYTOKINE

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

(2010) John S. Albin et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Lentiviral Vif Degrades the APOBEC3Z3/APOBEC3H Protein of Its Mammalian Host and Is Capable of Cross-Species Activity

(2010) R. S. LaRue et al.   JOURNAL OF VIROLOGY

Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

(2010) T. Kobayashi et al.   JOURNAL OF VIROLOGY

Ebola Virus Glycoprotein Counteracts BST-2/Tetherin Restriction in a Sequence-Independent Manner That Does Not Require Tetherin Surface Removal

(2010) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Serine-Threonine Ubiquitination Mediates Downregulation of BST-2/Tetherin and Relief of Restricted Virion Release by HIV-1 Vpu

(2010) A. A. Tokarev et al.   JOURNAL OF VIROLOGY

Long-Term Restriction by APOBEC3F Selects Human Immunodeficiency Virus Type 1 Variants with Restored Vif Function

(2010) J. S. Albin et al.   JOURNAL OF VIROLOGY

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

(2010) Heiko Hauser et al.   Retrovirology

Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment

(2010) Mathieu Dubé et al.   PLoS Pathogens

Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane

(2010) Jason Hammonds et al.   PLoS Pathogens

Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles

(2010) Kathleen Fitzpatrick et al.   PLoS Pathogens

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

(2009) David Perez-Caballero et al.   CELL

A Cellular Restriction Dictates the Permissivity of Nondividing Monocytes/Macrophages to Lentivirus and Gammaretrovirus Infection

(2009) Rajnish Kaushik et al.   Cell Host & Microbe

Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists

(2009) Fengwen Zhang et al.   Cell Host & Microbe

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

(2009) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimal Translation Initiation Enables Vif-Deficient Human Immunodeficiency Virus Type 1 To Escape Restriction by APOBEC3G

(2009) G. Hache et al.   JOURNAL OF VIROLOGY

The Transmembrane Domain of BST-2 Determines Its Sensitivity to Down-Modulation by Human Immunodeficiency Virus Type 1 Vpu

(2009) L. Rong et al.   JOURNAL OF VIROLOGY

Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope Glycoprotein

(2009) A. Le Tortorec et al.   JOURNAL OF VIROLOGY

Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a  TrCP-Dependent Mechanism

(2009) J. L. Douglas et al.   JOURNAL OF VIROLOGY

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration

(2009) R. K. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of HIV-1 by APOBEC3G is cytidine deaminase-dependent

(2009) Edward P. Browne et al.   VIROLOGY

Mutation of a Single Residue Renders Human Tetherin Resistant to HIV-1 Vpu-Mediated Depletion

(2009) Ravindra K. Gupta et al.   PLoS Pathogens

BCA2/Rabring7 Promotes Tetherin-Dependent HIV-1 Restriction

(2009) Kei Miyakawa et al.   PLoS Pathogens

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

(2009) Bastien Mangeat et al.   PLoS Pathogens

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

Antiretroelement Activity of APOBEC3H Was Lost Twice in Recent Human Evolution

(2008) Molly OhAinle et al.   Cell Host & Microbe

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells

(2008) C. Goujon et al.   JOURNAL OF VIROLOGY

The DNA Deaminase Activity of Human APOBEC3G Is Required for Ty1, MusD, and Human Immunodeficiency Virus Type 1 Restriction

(2008) A. J. Schumacher et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Enhancing immunity to HIV through APOBEC

(2008) Reuben S Harris   NATURE BIOTECHNOLOGY

Turning up the volume on mutational pressure: Is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)

(2008) Satish K Pillai et al.   Retrovirology