KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

(2018) Kristof Theys et al.   PLoS Genetics

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes

(2018) Michela Mazzon et al.   PLoS Pathogens

Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein

(2018) Hsin-Ping Chiu et al.   PLoS Pathogens

Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs

(2018) Tamiko Nishimura et al.   NUCLEIC ACIDS RESEARCH

Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice

(2018) Qingqing Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

(2018) Molly OhAinle et al.   eLife

TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein

(2017) Xiaojiao Zheng et al.   JOURNAL OF VIROLOGY

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

(2017) Matthew A. Takata et al.   NATURE

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Comprehensive classification of the PIN domain-like superfamily

(2017) Dorota Matelska et al.   NUCLEIC ACIDS RESEARCH

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

(2017) Irati Antzin-Anduetza et al.   Retrovirology

The CpG dinucleotide content of the HIV-1 envelope gene may predict disease progression

(2017) Mishi Kaushal Wasson et al.   Scientific Reports

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses

(2017) Andrew E. Shaw et al.   PLOS BIOLOGY

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond

(2017) Osamu Takeuchi   Wiley Interdisciplinary Reviews-RNA

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

(2016) Eleanor Gaunt et al.   eLife

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of zinc-finger anti-viral protein in host defense against Sindbis virus

(2015) Tatsuya Kozaki et al.   INTERNATIONAL IMMUNOLOGY

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes

(2015) Melody M.H. Li et al.   TRENDS IN CELL BIOLOGY

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

(2015) John B. Moldovan et al.   PLoS Genetics

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

(2015) John L. Goodier et al.   PLoS Genetics

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

MCPIP1 Suppresses Hepatitis C Virus Replication and Negatively Regulates Virus-Induced Proinflammatory Cytokine Responses

(2014) Ren-Jye Lin et al.   JOURNAL OF IMMUNOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals

(2014) Suzanne Pickering et al.   PLoS Pathogens

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

(2014) Fiona Tulloch et al.   eLife

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

(2013) Ren-Jye Lin et al.   NUCLEIC ACIDS RESEARCH

MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells

(2013) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

(2013) Richeng Mao et al.   PLoS Pathogens

Translational repression precedes and is required for ZAP-mediated mRNA decay

(2012) Yiping Zhu et al.   EMBO JOURNAL

Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA

(2012) Shoudeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase

(2012) J. Xu et al.   NUCLEIC ACIDS RESEARCH

MARF1 Regulates Essential Oogenic Processes in Mice

(2012) Y.-Q. Su et al.   SCIENCE

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRp40 and SRp55 Promote the Translation of Unspliced Human Immunodeficiency Virus Type 1 RNA

(2010) C. M. Swanson et al.   JOURNAL OF VIROLOGY

Genetic Inactivation of Poliovirus Infectivity by Increasing the Frequencies of CpG and UpA Dinucleotides within and across Synonymous Capsid Region Codons

(2009) C. C. Burns et al.   JOURNAL OF VIROLOGY

CGIN1: A Retroviral Contribution to Mammalian Genomes

(2009) A. Marco et al.   MOLECULAR BIOLOGY AND EVOLUTION

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

Role of Cellular RNA Processing Factors in Human Immunodeficiency Virus Type 1 mRNA Metabolism, Replication, and Infectivity

(2008) J. A. Jablonski et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein

(2008) Julie A. Kerns et al.   PLoS Genetics