Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

(2019) Roberta Cascella et al.   ACS Chemical Biology

The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis

(2019) Tomaipitinca et al.   Nutrients

Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases

(2019) Roberta Cascella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity

(2018) Christine Leibiger et al.   HUMAN MOLECULAR GENETICS

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

(2018) Ching-Chieh Chou et al.   NATURE NEUROSCIENCE

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

(2018) Fabio Di Domenico et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection

(2018) Antonella Tramutola et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy

(2017) Roberta Cascella et al.   FASEB JOURNAL

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

(2017) Richard J. Karpowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β oligomers (AβOs) in Alzheimer’s disease

(2017) Barbara Mroczko et al.   JOURNAL OF NEURAL TRANSMISSION

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

(2017) Tim E. Moors et al.   Molecular Neurodegeneration

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

(2017) Bing Zhu et al.   Nature Communications

Endocytosis regulates TDP-43 toxicity and turnover

(2017) Guangbo Liu et al.   Nature Communications

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

(2017) Peizhou Jiang et al.   Scientific Reports

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Cardiac Disorders as Risk Factors for Alzheimer's Disease

(2017) Tânia Corrêa de Toledo Ferraz Alves et al.   JOURNAL OF ALZHEIMERS DISEASE

The genetic background of Parkinson's disease: current progress and future prospects

(2016) K. Kalinderi et al.   ACTA NEUROLOGICA SCANDINAVICA

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

(2016) Michel Brahic et al.   ACTA NEUROPATHOLOGICA

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

The Immunoproteasome in oxidative stress, aging, and disease

(2016) Helen K. Johnston-Carey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

(2016) Roberta Cascella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Selective Autophagy

(2016) Gabriele Zaffagnini et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease

(2016) Antonella Tramutola et al.   Oxidative Medicine and Cellular Longevity

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity inDrosophila

(2016) Pedro Fernandez-Funez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

(2016) Elodie Monsellier et al.   Scientific Reports

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

(2015) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

Lifespan of mice and primates correlates with immunoproteasome expression

(2015) Andrew M. Pickering et al.   JOURNAL OF CLINICAL INVESTIGATION

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53

(2015) Eugenio Barone et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

SQSTM1 mutations – Bridging Paget disease of bone and ALS/FTLD

(2014) Sarah L. Rea et al.   EXPERIMENTAL CELL RESEARCH

UBE2E Ubiquitin-conjugating Enzymes and Ubiquitin Isopeptidase Y Regulate TDP-43 Protein Ubiquitination

(2014) Friederike Hans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

(2014) E. L. Scotter et al.   JOURNAL OF CELL SCIENCE

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Preconditioning stimulus of proteasome inhibitor enhances aggresome formation and autophagy in differentiated SH-SY5Y cells

(2014) Yeojin Bang et al.   NEUROSCIENCE LETTERS

TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells

(2014) Claudia Capitini et al.   PLoS One

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bag6/Bat3/Scythe: A novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation

(2013) Jin-Gu Lee et al.   BIOESSAYS

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease

(2013) JIANHUA JIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Protein oxidation in aging and the removal of oxidized proteins

(2013) Annika Höhn et al.   Journal of Proteomics

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

(2013) M. L. Burr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

(2013) Tobias Jung et al.   Redox Biology

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

(2012) Fabio Di Domenico et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins

(2012) Andrew M. Pickering et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway

(2012) Jochen Klucken et al.   Autophagy

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress

(2012) Marc Kästle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)

(2012) Michaeline L. Hebron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster

(2012) A. M. Pickering et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications

(2012) Idit Shachar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Obesity, Insulin Resistance, and Alzheimer's Disease

(2012) Kerry L. Hildreth et al.   Obesity

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination

(2012) Eric B. Dammer et al.   PLoS One

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

(2012) B. Mannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease

(2011) Thomas S. Wingo   ARCHIVES OF NEUROLOGY

Nitrosative protein tyrosine modifications: biochemistry and functional significance

(2011) Woon-Seok Yeo et al.   BMB Reports

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death

(2011) Dong-Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress-Mediated Regulation of Proteasome Complexes

(2011) Charity T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

(2011) Edward B. Lee et al.   NATURE REVIEWS NEUROSCIENCE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Behavioral Defects in Chaperone-Deficient Alzheimer's Disease Model Mice

(2011) Juhi Ojha et al.   PLoS One

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions

(2010) Tilman Grune et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Lipofuscin inhibits the proteasome by binding to surface motifs

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Lysosomal Degradation of α-Synucleinin Vivo

(2010) Sally K. Mak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps

(2010) Bella Groisman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Immunoproteasome deficiency alters retinal proteasome’s response to stress

(2010) Stacy A. Hussong et al.   JOURNAL OF NEUROCHEMISTRY

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Multiplex SILAC Analysis of a Cellular TDP-43 Proteinopathy Model Reveals Protein Inclusions Associated with SUMOylation and Diverse Polyubiquitin Chains

(2010) Nicholas T. Seyfried et al.   MOLECULAR & CELLULAR PROTEOMICS

Mutations of optineurin in amyotrophic lateral sclerosis

(2010) Hirofumi Maruyama et al.   NATURE

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43

(2009) Makoto Urushitani et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Incidence and remaining lifetime risk of Parkinson disease in advanced age

(2009) J. A. Driver et al.   NEUROLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular genetics of Alzheimer's disease: An update

(2008) Nathalie Brouwers et al.   ANNALS OF MEDICINE

Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease

(2008) Christopher D. Aluise et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

(2008) Matthew J. Winton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE

Early Stages for Parkinson’s Development: α-Synuclein Misfolding and Aggregation

(2008) Junping Yu et al.   Journal of Neuroimmune Pharmacology

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE