It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

(2015) Yanuar Alan Sulistio et al.   MOLECULAR NEUROBIOLOGY

The unravelling of the ubiquitin system

(2015) Aaron Ciechanover   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

(2015) Tomohiro Nakamura et al.   NEUROBIOLOGY OF DISEASE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Oxidative Stress in Aging: Advances in Proteomic Approaches

(2014) Daniel Ortuño-Sahagún et al.   Oxidative Medicine and Cellular Longevity

Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer’s Disease

(2014) Ryo Saito et al.   PLoS One

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

(2014) Mingming Zhang et al.   Scientific Reports

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

(2013) Javier H. Jara et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Parkin overexpression ameliorates hippocampal long-term potentiation and  -amyloid load in an Alzheimer's disease mouse model

(2013) X. Hong et al.   HUMAN MOLECULAR GENETICS

Negative Regulation of 26S Proteasome Stability via Calpain-mediated Cleavage of Rpn10 Subunit upon Mitochondrial Dysfunction in Neurons

(2013) Qian Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: Insights from proteomics

(2013) Marzia Perluigi et al.   Proteomics Clinical Applications

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Hrd1 Facilitates Tau Degradation and Promotes Neuron Survival

(2012) Y.X. Shen et al.   CURRENT MOLECULAR MEDICINE

Roles of Ubiquitin in Endoplasmic Reticulum-Associated Protein Degradation (ERAD)

(2012) Veit Goder   CURRENT PROTEIN & PEPTIDE SCIENCE

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

(2012) T. Watanabe et al.   JOURNAL OF NEUROSCIENCE

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer’s disease

(2012) Paula van Tijn et al.   NEUROCHEMISTRY INTERNATIONAL

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1

(2011) Mingming Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

(2010) Qian Huang et al.   APOPTOSIS

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions

(2010) Tilman Grune et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The potential role of ubiquitin c-terminal hydrolases in oncogenesis

(2010) Ying Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Modelling the Role of UCH-L1 on Protein Aggregation in Age-Related Neurodegeneration

(2010) Carole J. Proctor et al.   PLoS One

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

(2010) F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Ubiquitination in Endocytic Trafficking of G-Protein-Coupled Receptors

(2010) James N. Hislop et al.   TRAFFIC

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

(2008) Nicolle Breusing et al.   BIOLOGICAL CHEMISTRY

Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes

(2008) Valentina Cecarini et al.   BRAIN RESEARCH

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

The proteasome and its role in the degradation of oxidized proteins

(2008) Tobias Jung et al.   IUBMB LIFE

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage: ubiquitin marks the spot

(2008) Eric J Bennett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE