Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)
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Title
Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 6, Pages 4103-4115
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2012-12-21
DOI
10.1074/jbc.m112.419945
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Note: Only part of the references are listed.- The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities
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- Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
- (2011) S. Z. Imam et al. JOURNAL OF NEUROSCIENCE
- TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
- (2011) Fabienne C Fiesel et al. Molecular Neurodegeneration
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy
- (2010) Osamu Yokota et al. ACTA NEUROPATHOLOGICA
- Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness
- (2010) Felix Geser et al. ARCHIVES OF NEUROLOGY
- Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
- (2010) Jianfei Qi et al. CANCER CELL
- Parkinson's disease: insights from pathways
- (2010) M. R. Cookson et al. HUMAN MOLECULAR GENETICS
- TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
- (2010) C. Lagier-Tourenne et al. HUMAN MOLECULAR GENETICS
- Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
- (2010) Brigit E. Riley et al. JOURNAL OF CELL BIOLOGY
- TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
- (2010) Ian RA Mackenzie et al. LANCET NEUROLOGY
- Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
- (2010) Preeti J Khandelwal et al. Molecular Neurodegeneration
- Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease
- (2010) Andrew King et al. NEUROPATHOLOGY
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
- (2010) H. S. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyotrophic Lateral Sclerosis–Plus Syndrome With TAR DNA-Binding Protein-43 Pathology
- (2009) Leo F. McCluskey et al. ARCHIVES OF NEUROLOGY
- Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling
- (2009) D. Sha et al. HUMAN MOLECULAR GENETICS
- Parkin promotes intracellular A 1-42 clearance
- (2009) M. P. Burns et al. HUMAN MOLECULAR GENETICS
- Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function
- (2009) Kenneth M. Rosen et al. JOURNAL OF NEUROSCIENCE RESEARCH
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43mutation in familial amyotrophic lateral sclerosis
- (2008) Akio Yokoseki et al. ANNALS OF NEUROLOGY
- TDP-43A315T mutation in familial motor neuron disease
- (2008) Michael A. Gitcho et al. ANNALS OF NEUROLOGY
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- Evidence of Multisystem Disorder in Whole-Brain Map of Pathological TDP-43 in Amyotrophic Lateral Sclerosis
- (2008) Felix Geser et al. ARCHIVES OF NEUROLOGY
- PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
- (2008) Yongsung Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Fumiyo Ikeda et al. EMBO REPORTS
- Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice
- (2008) Jose A. Rodríguez-Navarro et al. HUMAN MOLECULAR GENETICS
- Combined kinase inhibition modulates parkin inactivation
- (2008) E. Rubio de la Torre et al. HUMAN MOLECULAR GENETICS
- α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution
- (2008) Kohichi Kawahara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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