Bag6/Bat3/Scythe: A novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases

(2012) Timothy P Wakeman et al.   EMBO JOURNAL

A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain

(2012) Philip Long et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of Chaperone Effects on a Yeast Prion by Cochaperone Sgt2

(2012) D. A. Kiktev et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

A Novel BAT3 Sequence Generated by Alternative RNA Splicing of Exon 11B Displays Cell Type-Specific Expression and Impacts on Subcellular Localization

(2012) Nadine Kämper et al.   PLoS One

A Novel, Non-Apoptotic Role for Scythe/BAT3: A Functional Switch between the Pro- and Anti-Proliferative Roles of p21 during the Cell Cycle

(2012) Sheila T. Yong et al.   PLoS One

BAT3 Regulates Mycobacterium tuberculosis Protein ESAT-6-Mediated Apoptosis of Macrophages

(2012) Ajay Grover et al.   PLoS One

SGTA antagonizes BAG6-mediated protein triage

(2012) P. Leznicki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface

(2012) Justin W. Chartron et al.   Cell Reports

SGTA Recognizes a Noncanonical Ubiquitin-like Domain in the Bag6-Ubl4A-Trc35 Complex to Promote Endoplasmic Reticulum-Associated Degradation

(2012) Yue Xu et al.   Cell Reports

A biochemical analysis of the constraints of tail-anchored protein biogenesis

(2011) Pawel Leznicki et al.   BIOCHEMICAL JOURNAL

Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy

(2011) Yanfen Liu et al.   CELL RESEARCH

γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expression

(2011) Nadine Kämper et al.   FASEB JOURNAL

Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

(2011) Karina Kaczmarek et al.   MOLECULAR BIOLOGY OF THE CELL

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

(2011) Fei Wang et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum

(2011) Jasper H. L. Claessen et al.   PLoS One

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

(2011) Robert Ernst et al.   PLOS BIOLOGY

ERAD ubiquitin ligases

(2010) Martin Mehnert et al.   BIOESSAYS

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

BAG-6 is essential for selective elimination of defective proteasomal substrates

(2010) Ryosuke Minami et al.   JOURNAL OF CELL BIOLOGY

Asna1/TRC40-mediated membrane insertion of tail-anchored proteins

(2010) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

Bat3 promotes the membrane integration of tail-anchored proteins

(2010) P. Leznicki et al.   JOURNAL OF CELL SCIENCE

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

(2010) Leandro C. Cerchietti et al.   JOURNAL OF CLINICAL INVESTIGATION

Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm

(2010) Yao-Yuan Hsieh et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma

(2009) Tomohide Tsukahara et al.   CANCER SCIENCE

Sequential interplay between BAG6 and HSP70 upon heat shock

(2009) A. Corduan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural insight into the membrane insertion of tail-anchored proteins by Get3

(2009) Atsushi Yamagata et al.   GENES TO CELLS

The structural basis of tail-anchored membrane protein recognition by Get3

(2009) Agnieszka Mateja et al.   NATURE

The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion

(2009) Junbin Hu et al.   PLoS One

Structural insights into tail-anchored protein binding and membrane insertion by Get3

(2009) Gunes Bozkurt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model for eukaryotic tail-anchored protein binding based on the structure of Get3

(2009) C. J. M. Suloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2

(2009) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis

(2008) Toru Sasaki et al.   JOURNAL OF CELL BIOLOGY

BAT3 and SET1A Form a Complex with CTCFL/BORIS To Modulate H3K4 Histone Dimethylation and Gene Expression

(2008) P. Nguyen et al.   MOLECULAR AND CELLULAR BIOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis

(2008) S. M. J. Harney et al.   RHEUMATOLOGY