Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

(2017) Chandrashekhar D. Kamat et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

(2017) Magali Dumont et al.   JOURNAL OF ALZHEIMERS DISEASE

NADPH oxidases contribute to autophagy regulation

(2014) Ju Huang et al.   Autophagy

NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone

(2012) G. Frazziano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox and Reactive Oxygen Species Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis

(2012) Myriam Bourens et al.   ANTIOXIDANTS & REDOX SIGNALING

The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease

(2012) María E. Solesio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Targeting Heme Oxygenase-1 in Vascular Disease

(2012) William Durante   CURRENT DRUG TARGETS

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial regulation of epigenetics and its role in human diseases

(2012) Sheroy Minocherhomji et al.   Epigenetics

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of mitochondrial biogenesis

(2012) Claude A. Piantadosi et al.   FREE RADICAL BIOLOGY AND MEDICINE

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Nitric oxide signaling in hypoxia

(2012) J. J. David Ho et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial diseases

(2012) Anthony HV Schapira   LANCET

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

The Neglected Significance of “Antioxidative Stress”

(2012) B. Poljsak et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Oxidative Stress in Heart Failure: What Are We Missing?

(2011) Douglas B. Sawyer   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Hydrogen Peroxide as a Signaling Molecule

(2011) Elizabeth Veal et al.   ANTIOXIDANTS & REDOX SIGNALING

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer

(2011) Louise Hedskog et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of oxidative stress and antioxidant enzymes in Crohn's disease

(2011) Marisa Iborra et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanism of the Nrf2/Keap1/ARE signaling system

(2011) V. O. Tkachev et al.   BIOCHEMISTRY-MOSCOW

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction in diabetic cardiomyopathy

(2011) Jennifer G. Duncan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytosolic phospholipase A2, lipoxygenase metabolites, and reactive oxygen species

(2011) Cheol-Min Kim et al.   BMB Reports

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Enabling Innovative Translational Research in Acute Kidney Injury

(2011) Abolfazl Zarjou et al.   CTS-Clinical and Translational Science

Mitochondria in Chronic Liver Disease

(2011) Ignazio Grattagliano et al.   CURRENT DRUG TARGETS

Re-Wiring the Circuit: Mitochondria as a Pharmacological Target in Liver Disease

(2011) C. V. Diogo et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondria: commanders of innate immunity and disease?

(2011) Suzanne M Cloonan et al.   CURRENT OPINION IN IMMUNOLOGY

Vitamin E in Oxidant Stress-Related Cardiovascular Pathologies: Focus on Experimental Studies

(2011) Belma Turan et al.   CURRENT PHARMACEUTICAL DESIGN

Antioxidant Vitamins and Cardiovascular Disease

(2011) Jorge M. Nunez-Cordoba et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Role of Nitric Oxide on Endothelial Function

(2011) Dimitris Tousoulis et al.   Current Vascular Pharmacology

Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms

(2011) Antonio Martínez-Ruiz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species

(2011) Randy J. Giedt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease

(2011) Nilanjan Ghosh et al.   FREE RADICAL RESEARCH

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy in hematological malignancies: role of reactive oxygen species

(2011) Ganchimeg Ishdorj et al.   LEUKEMIA & LYMPHOMA

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Vascular-derived reactive oxygen species for homeostasis and diseases

(2011) Kimio Satoh et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitochondrial Network Determines Intracellular ROS Dynamics and Sensitivity to Oxidative Stress through Switching Inter-Mitochondrial Messengers

(2011) Junseong Park et al.   PLoS One

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress

(2011) Ronald C. Taylor et al.   PLoS Computational Biology

Mitochondria-Targeted Antioxidants in the Treatment of Disease

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

The Intermembrane Space of Mitochondria

(2010) Johannes M. Herrmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dynamics in Diabetes

(2010) Yisang Yoon et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway

(2010) Xinghua Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial morphology and cardiovascular disease

(2010) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Effect of NF-κB Signaling on Apoptosis in Chronic Inflammation-Associated Carcinogenesis

(2010) H. Wang et al.   CURRENT CANCER DRUG TARGETS

Oxidative Stress and Endothelial Dysfunction in Cardiovascular Disease: Mitochondria-Targeted Therapeutics

(2010) M. Rocha et al.   CURRENT MEDICINAL CHEMISTRY

Role of Antioxidants in Redox Regulation of Diabetic Cardiovascular Complications

(2010) Belma Turan   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes

(2010) A. Makino et al.   DIABETOLOGIA

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Roles of mitochondria in human disease: Figure 1

(2010) Michael R. Duchen et al.   Essays in Biochemistry

Regulation of the autophagic machinery in human neutrophils

(2010) Ioannis Mitroulis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antioxidant approaches for the treatment of Alzheimer’s disease

(2010) Hyun Pil Lee et al.   Expert Review of Neurotherapeutics

H2O2-induced mitochondrial fragmentation in C2C12 myocytes

(2010) Xiying Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Contributions Of Antioxidant Activity Of Lipoic Acid In Reducing Neurogenerative Progression Of Parkinson’s Disease: A Review

(2010) Dayane Pessoa De Araújo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Mitochondria as integrators of signal transduction and energy production in cardiac physiology and disease

(2010) Michael A. Frohman   JOURNAL OF MOLECULAR MEDICINE-JMM

Heme Oxygenase-1 Inhibits Renal Tubular Macroautophagy in Acute Kidney Injury

(2010) S. Bolisetty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NF- B in Renal Inflammation

(2010) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antioxidant Vitamins and Their Use in Preventing Cardiovascular Disease

(2010) Dan Farbstein et al.   MOLECULES

Reactive oxygen species in TNFα-induced signaling and cell death

(2010) Michael J. Morgan et al.   MOLECULES AND CELLS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria

(2010) H. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

Mitochondria, reactive oxygen species and cadmium toxicity in the kidney

(2010) Glenda Gobe et al.   TOXICOLOGY LETTERS

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Antioxidant enzyme gene transfer for ischemic diseases

(2009) Jian Wu et al.   ADVANCED DRUG DELIVERY REVIEWS

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

(2009) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

(2009) Claudio Napoli et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway

(2009) G Liot et al.   CELL DEATH AND DIFFERENTIATION

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

The Ligand Binding Battle at Cytochrome c Oxidase

(2009) Mark T. Gladwin et al.   CIRCULATION RESEARCH

The role of mitochondria in health and disease

(2009) Darcy L Johannsen et al.   CURRENT OPINION IN PHARMACOLOGY

Mitochondrial Nitric Oxide Synthase: A Masterpiece of Metabolic Adaptation, Cell Growth, Transformation, and Death

(2009) Paola V. Finocchietto et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease

(2009) Danielle Morse et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of the nitric oxide signaling pathway and targets for drug development

(2009) Nathan et al.   Frontiers in Bioscience-Landmark

The resolution of inflammation: Anti-inflammatory roles for NF-κB

(2009) Toby Lawrence et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide-mediated inhibition of NFκB regulates hyperthermia-induced apoptosis

(2009) Natarajan Aravindan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway

(2009) Yu Jeong Byun et al.   NEUROSCIENCE LETTERS

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial fusion and division: Regulation and role in cell viability

(2009) Giovanni Benard et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells

(2009) Sheng-Hao Wang et al.   TOXICOLOGICAL SCIENCES

Oxidative Stress Induces Parallel Autophagy and Mitochondria Dysfunction in Human Glioma U251 Cells

(2009) Hongyu Zhang et al.   TOXICOLOGICAL SCIENCES

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes☆

(2008) Mei-Jie Jou   ADVANCED DRUG DELIVERY REVIEWS

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

(2008) Hua Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Catalytic Antioxidants and Neurodegeneration

(2008) Tamara R. Golden et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia

(2008) Xue-Qin Song et al.   BIOLOGICAL PSYCHIATRY

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Antioxidant Gene Therapy for Cardiovascular Disease

(2008) Anna-Liisa Levonen et al.   CIRCULATION

Crosstalk Between Autophagy and Apoptosis in Heart Disease

(2008) Kazuhiko Nishida et al.   CIRCULATION RESEARCH

Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

(2008) Tomoko Nishino et al.   FEBS Journal

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells

(2008) Jia Yang et al.   FREE RADICAL RESEARCH

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

(2008) Gjumrakch Aliev et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

(2008) Marina Jendrach et al.   MITOCHONDRION

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Generation of Reactive Oxygen Species by Mitochondrial Complex I: Implications in Neurodegeneration

(2008) Romana Fato et al.   NEUROCHEMICAL RESEARCH

Post-translational modifications induced by nitric oxide (NO): Implication in cancer cells apoptosis

(2008) Lissbeth Leon et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One

Antioxidants as Potential Therapeutics for Lung Fibrosis

(2007) Brian J. Day   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Medicine: Pharmacological targeting of mitochondria in disease

(2007) J S Armstrong   BRITISH JOURNAL OF PHARMACOLOGY

Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages

(2007) Takashi Ashino et al.   MOLECULAR IMMUNOLOGY

Mitochondria and skin disease

(2002) M. A. Birch-Machin   CLINICAL AND EXPERIMENTAL DERMATOLOGY