ROS as Regulators of Mitochondrial Dynamics in Neurons

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation

(2018) Qiong Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family

(2018) Lois Dankwa et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

(2018) Clara Hiu-Ling Hung et al.   Redox Biology

Leigh-like neuroimaging features associated with new biallelic mutations in OPA1

(2017) Anna Rubegni et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6/2 fragment model

(2017) Tanja Hering et al.   EXPERIMENTAL NEUROLOGY

Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer’s disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities

(2017) Chandra Sekhar Kuruva et al.   HUMAN MOLECULAR GENETICS

CENP-F couples cargo to growing and shortening microtubule ends

(2017) Gil Kanfer et al.   MOLECULAR BIOLOGY OF THE CELL

Amyloid β-42 induces neuronal apoptosis by targeting mitochondria

(2017) Xiao-Jian Han et al.   Molecular Medicine Reports

Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease

(2017) Patricia Martín-Maestro et al.   Oxidative Medicine and Cellular Longevity

An emerging role for mitochondrial dynamics in schizophrenia

(2017) Kyle H. Flippo et al.   SCHIZOPHRENIA RESEARCH

p47Phox/CDK5/DRP1-Mediated Mitochondrial Fission Evokes PV Cell Degeneration in the Rat Dentate Gyrus Following Status Epilepticus

(2017) Ji-Eun Kim et al.   Frontiers in Cellular Neuroscience

c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

(2017) Lujun Zhou et al.   Cell Death & Disease

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

(2017) Amit U. Joshi et al.   Oncotarget

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis

(2017) Juanjuan Zhang et al.   Scientific Reports

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease

(2016) Zhenzhen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis

(2016) Volodya Altanbyek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial fission and fusion

(2016) H. Lee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations

(2016) Clément A. Gautier et al.   HUMAN MOLECULAR GENETICS

Mitochondrial fission and fusion in secondary brain damage after CNS insults

(2016) Justin Balog et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO-regulated mitochondrial function in Parkinson's disease

(2016) Ana Cristina Guerra de Souza et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology

(2016) Juan Manuel Chao de la Barca et al.   NEUROBIOLOGY OF DISEASE

RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

(2016) S. Piras et al.   Oxidative Medicine and Cellular Longevity

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP

(2016) Emily Filichia et al.   Scientific Reports

Calcium-Sensing Receptor: A Key Target for Extracellular Calcium Signaling in Neurons

(2016) Brian L. Jones et al.   Frontiers in Physiology

Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis

(2016) Aurélie M. C. Millet et al.   Annals of Clinical and Translational Neurology

ROS Produced by NOX2 Controls In Vitro Development of Cerebellar Granule Neurons Development

(2015) Mauricio Olguín-Albuerne et al.   ASN Neuro

PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

(2015) Madhuparna Roy et al.   Autophagy

Mitochondrial ROS metabolism: 10 Years later

(2015) A. Y. Andreyev et al.   BIOCHEMISTRY-MOSCOW

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Mitochondrial dynamics and inherited peripheral nerve diseases

(2015) Davide Pareyson et al.   NEUROSCIENCE LETTERS

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons

(2015) L Y Shields et al.   Cell Death & Disease

Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling

(2015) Kaifeng Guo et al.   PLoS One

Shaping the dynamic mitochondrial network

(2014) Laura L Lackner   BMC BIOLOGY

The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions

(2014) Yutaro Komuro et al.   Developmental Neurobiology

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death

(2014) A. Martorell-Riera et al.   EMBO JOURNAL

MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons

(2014) Wenzhang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Organelle-specific initiation of cell death

(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics

(2014) M. Norton et al.   Science Signaling

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

(2013) Hiromi Sesaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy-mediated turnover of Dynamin-related Protein 1

(2013) Phillip R Purnell et al.   BMC NEUROSCIENCE

OPA1 loss of function affects in vitro neuronal maturation

(2013) Ambre M. Bertholet et al.   BRAIN

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Principles of the mitochondrial fusion and fission cycle in neurons

(2013) M. Cagalinec et al.   JOURNAL OF CELL SCIENCE

Declines in Drp1 and Parkin Expression Underlie DNA Damage-Induced Changes in Mitochondrial Length and Neuronal Death

(2013) D. B. Wang et al.   JOURNAL OF NEUROSCIENCE

The role of the mitochondrial calcium uniporter in cerebral ischemia/reperfusion injury in rats involves regulation of mitochondrial energy metabolism

(2013) QIN ZHAO et al.   Molecular Medicine Reports

Switching Responses: Spatial and Temporal Regulators of Axon Guidance

(2013) Andrew Kaplan et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures

(2013) Edina A. Wappler et al.   PLoS One

Kissing and nanotunneling mediate intermitochondrial communication in the heart

(2013) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due toOPA1Mutations

(2013) Andrea M. Schild et al.   Biomed Research International

Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions

(2013) Ryan J. Mailloux et al.   Redox Biology

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies

(2012) Maria Manczak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons

(2012) Mi-Hyang Cho et al.   BRAIN RESEARCH

N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress

(2012) Josie J. Gray et al.   BRAIN RESEARCH

The intracellular redox state is a core determinant of mitochondrial fusion

(2012) Timothy Shutt et al.   EMBO REPORTS

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

(2012) Yusuke Kageyama et al.   JOURNAL OF CELL BIOLOGY

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease

(2012) Theodore J. Wilson et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Age-Dependent Association of the Polymorphisms in the Mitochondria-Shaping Gene, OPA1, With Blood Pressure and Hypertension in Korean Population

(2011) Hyun-Seok Jin et al.   AMERICAN JOURNAL OF HYPERTENSION

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reply: Spastic paraplegia in 'dominant optic atrophy plus' phenotype due to OPA1 mutation

(2011) P. Yu-Wai-Man et al.   BRAIN

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

(2011) Pinwei Huang et al.   PLoS One

TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL

(2010) J J Kim et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dynamics in cell death and neurodegeneration

(2010) Dong-Hyung Cho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

(2010) J. Kim et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity

(2010) Arezu Jahani-Asl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lethalde NovoMutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

(2010) Chuang-Rung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

(2010) Jason A Mears et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serum deprivation-induced reactive oxygen species production is mediated by Romo1

(2009) Seung Baek Lee et al.   APOPTOSIS

Complexity of mitochondrial dynamics in neurons and its control by ADP produced during synaptic activity

(2009) Sergei L. Mironov   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The cell-type specificity of mitochondrial dynamics

(2009) Andrey V. Kuznetsov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

OPA1-associated disorders: Phenotypes and pathophysiology

(2009) Patrizia Amati-Bonneau et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Recent advances in our understanding of neurodegeneration

(2009) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

Construction of Functional Interaction Networks through Consensus Localization Predictions of the Human Proteome

(2009) Solip Park et al.   JOURNAL OF PROTEOME RESEARCH

Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas

(2009) Yung-Yen Chiang et al.   MODERN PATHOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1

(2008) Ansgar Santel et al.   IUBMB LIFE

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

A phenotypic variation of dominant optic atrophy and deafness (ADOAD) due to a novel OPA1 mutation

(2008) M. Liguori et al.   JOURNAL OF NEUROLOGY

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial Dysfunction and Psychiatric Disorders

(2008) Gislaine T. Rezin et al.   NEUROCHEMICAL RESEARCH

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA