The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

(2019) Joanna R. Kovalski et al.   MOLECULAR CELL

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

(2019) Riko Hatakeyama et al.   Autophagy

Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae

(2019) Melissa N. Locke et al.   CELL CYCLE

TORC2 controls endocytosis through plasma membrane tension

(2019) Margot Riggi et al.   JOURNAL OF CELL BIOLOGY

Sphingolipids and membrane targets for therapeutics

(2019) Robbie Loewith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2

(2019) Maria Nieves Martinez Marshall et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

(2019) Hiroshi Senoo et al.   NATURE CELL BIOLOGY

Role of MCC/Eisosome in Fungal Lipid Homeostasis

(2019) Zahumensky et al.   Biomolecules

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Cryo-EM structure of human mTOR complex 2

(2018) Xizi Chen et al.   CELL RESEARCH

Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals

(2018) Rafael Lucena et al.   CURRENT BIOLOGY

Modulation of TORC2 Signaling by a Conserved Lkb1 Signaling Axis in Budding Yeast

(2018) Maria Alcaide-Gavilán et al.   GENETICS

Target Of Rapamycin Complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae

(2018) Robbie Loewith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the human mTORC2 core complex

(2018) Edward Stuttfeld et al.   eLife

Modulation of TORC2 Signaling by a Conserved Lkb1 Signaling Axis in Budding Yeast

(2018) Maria Alcaide-Gavilán et al.   GENETICS

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2

(2018) Margot Riggi et al.   NATURE CELL BIOLOGY

A fluorescent membrane tension probe

(2018) Adai Colom et al.   Nature Chemistry

Caveolae: Structure, Function, and Relationship to Disease

(2018) Robert G. Parton   Annual Review of Cell and Developmental Biology

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2

(2018) Kristin L. Leskoske et al.   GENES & DEVELOPMENT

Rab5 GTPases are required for optimal TORC2 function

(2018) Melissa N. Locke et al.   JOURNAL OF CELL BIOLOGY

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

Ypk1/Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodelling after membrane stresses

(2017) Riko Hatakeyama et al.   JOURNAL OF CELL SCIENCE

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

(2017) Manoël Prouteau et al.   NATURE

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

(2017) Angelica Benavides-Serrato et al.   PLoS One

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

(2017) Manikandan Karuppasamy et al.   Nature Communications

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae

(2016) Christopher G. Alvaro et al.   GENETICS

Calcium channel regulator Mid1 links TORC2-mediated changes in mitochondrial respiration to autophagy

(2016) Ariadne Vlahakis et al.   JOURNAL OF CELL BIOLOGY

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

(2016) Huirong Yang et al.   Protein & Cell

Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae

(2016) Christopher G. Alvaro et al.   GENETICS

Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose

(2015) Tomoyuki Hatano et al.   CELL CYCLE

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

(2015) Delphine Rispal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eisosomes provide membrane reservoirs for rapid expansion of the yeast plasma membrane

(2015) R. Kabeche et al.   JOURNAL OF CELL SCIENCE

mTOR in health and in sickness

(2015) Dritan Liko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae

(2015) Wataru Nomura et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

When Physics Takes Over: BAR Proteins and Membrane Curvature

(2015) Mijo Simunovic et al.   TRENDS IN CELL BIOLOGY

The SIN1-PH Domain Connects mTORC2 to PI3K

(2015) H.-X. Yuan et al.   Cancer Discovery

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

(2015) Alexander Muir et al.   eLife

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

TOR complex 2–Ypk1 signaling regulates actin polarization via reactive oxygen species

(2014) Brad J. Niles et al.   MOLECULAR BIOLOGY OF THE CELL

TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation

(2014) Brad J. Niles et al.   Cell Reports

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

(2013) Dudley W. Lamming et al.   FASEB JOURNAL

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae

(2012) Brad J. Niles et al.   CELL CYCLE

Regulation of TOR by small GTPases

(2012) Raúl V Durán et al.   EMBO REPORTS

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Endoplasmic reticulum is a main localization site of mTORC2

(2011) Delphine R. Boulbés et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Evolution of the TOR Pathway

(2011) Teunis J. P. van Dam et al.   JOURNAL OF MOLECULAR EVOLUTION

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

(2009) Doris Berchtold et al.   MOLECULAR BIOLOGY OF THE CELL

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

TOR1 and TOR2 Have Distinct Locations in Live Cells

(2008) Thomas W. Sturgill et al.   EUKARYOTIC CELL

The Sphingolipid Long-chain Base-Pkh1/2-Ypk1/2 Signaling Pathway Regulates Eisosome Assembly and Turnover

(2008) Guangzuo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY