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Title
4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1
Authors
Keywords
mTORC1, structure, cryo-electron microscopy
Journal
Protein & Cell
Volume 7, Issue 12, Pages 878-887
Publisher
Springer Nature
Online
2016-12-01
DOI
10.1007/s13238-016-0346-6
References
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Related references
Note: Only part of the references are listed.- Tor forms a dimer through an N-terminal helical solenoid with a complex topology
- (2016) Domagoj Baretić et al. Nature Communications
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- (2015) C. Stretton et al. BIOCHEMICAL JOURNAL
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- (2015) Hai-Xin Yuan et al. GENES & DEVELOPMENT
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
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- (2013) Xueming Li et al. NATURE METHODS
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
- (2011) Elaine A. Dunlop et al. Autophagy
- mTOR signaling in disease
- (2011) Eva Dazert et al. CURRENT OPINION IN CELL BIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
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