Role of MCC/Eisosome in Fungal Lipid Homeostasis

Plasma membrane architecture protects Candida albicans from killing by copper

(2019) Lois M. Douglas et al.   PLoS Genetics

TORC2 controls endocytosis through plasma membrane tension

(2019) Margot Riggi et al.   JOURNAL OF CELL BIOLOGY

Lateral plasma membrane compartmentalization links protein function and turnover

(2018) Jon V Busto et al.   EMBO JOURNAL

Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells

(2018) Kan-na Tomioku et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Sphingolipids activate the endoplasmic reticulum stress surveillance pathway

(2018) Francisco Piña et al.   JOURNAL OF CELL BIOLOGY

TOR Complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites

(2018) Françoise M. Roelants et al.   MOLECULAR BIOLOGY OF THE CELL

Conformation-dependent partitioning of yeast nutrient transporters into starvation-protective membrane domains

(2018) Christos Gournas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ergosterol is mainly located in the cytoplasmic leaflet of the yeast plasma membrane

(2018) Lukasz M. Solanko et al.   TRAFFIC

Steric exclusion and protein conformation determine the localization of plasma membrane transporters

(2018) Frans Bianchi et al.   Nature Communications

Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2

(2018) Margot Riggi et al.   NATURE CELL BIOLOGY

The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization

(2018) Gongshe Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two eisosome proteins play opposite roles in autophagic control and sustain cell integrity, function and pathogenicity in Beauveria bassiana

(2017) Long-Bin Zhang et al.   ENVIRONMENTAL MICROBIOLOGY

mRNA decay is regulated via sequestration of the conserved 5′-3′ exoribonuclease Xrn1 at eisosome in yeast

(2017) Katarína Vaškovičová et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Genes Important forSchizosaccharomyces pombeMeiosis Identified Through a Functional Genomics Screen

(2017) Julie Blyth et al.   GENETICS

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

(2017) Takuma Tsuji et al.   eLife

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Genes Important forSchizosaccharomyces pombeMeiosis Identified Through a Functional Genomics Screen

(2017) Julie Blyth et al.   GENETICS

Transmembrane voltage: Potential to induce lateral microdomains

(2016) Jan Malinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status

(2016) Sara García-Marqués et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans

(2016) Hong X. Wang et al.   MOLECULAR BIOLOGY OF THE CELL

ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activities

(2016) Athen N. Kimberlin et al.   PLANT PHYSIOLOGY

Phosphoinositides in endocytosis

(2015) York Posor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Eisosome Ultrastructure and Evolution in Fungi, Microalgae, and Lichens

(2015) Jae-Hyeok Lee et al.   EUKARYOTIC CELL

Eisosomes Regulate Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Cortical Clusters and Mitogen-activated Protein (MAP) Kinase Signaling upon Osmotic Stress

(2015) Ruth Kabeche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

(2015) Katelyn Bartlett et al.   JOURNAL OF BIOSCIENCES

Eisosomes provide membrane reservoirs for rapid expansion of the yeast plasma membrane

(2015) R. Kabeche et al.   JOURNAL OF CELL SCIENCE

The zinc cluster proteins Upc2 and Ecm22 promote filamentation inSaccharomyces cerevisiaeby sterol biosynthesis-dependent and -independent pathways

(2015) Kelly Woods et al.   MOLECULAR MICROBIOLOGY

Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2

(2015) Huiseon Yang et al.   Nature Communications

Characterization of AnNce102 and its role in eisosome stability and sphingolipid biosynthesis

(2015) Alexandros Athanasopoulos et al.   Scientific Reports

Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence

(2015) Lifang Li et al.   PLoS Pathogens

Evolutionarily Conserved 5’-3’ Exoribonuclease Xrn1 Accumulates at Plasma Membrane-Associated Eisosomes in Post-Diauxic Yeast

(2015) Tomas Grousl et al.   PLoS One

Depolarization affects the lateral microdomain structure of yeast plasma membrane

(2014) Petr Herman et al.   FEBS Journal

A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast

(2014) Chao-Wen Wang et al.   JOURNAL OF CELL BIOLOGY

A Pil1-Sle1-Syj1-Tax4 functional pathway links eisosomes with PI(4,5)P2 regulation

(2014) R. Kabeche et al.   JOURNAL OF CELL SCIENCE

A role for eisosomes in maintenance of plasma membrane phosphoinositide levels

(2014) Florian Fröhlich et al.   MOLECULAR BIOLOGY OF THE CELL

TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation

(2014) Brad J. Niles et al.   Cell Reports

Membrane Microdomains, Rafts, and Detergent-Resistant Membranes in Plants and Fungi

(2013) Jan Malinsky et al.   Annual Review of Plant Biology

Regulation of mating in the budding yeast Saccharomyces cerevisiae by the zinc cluster proteins Sut1 and Sut2

(2013) Claudia Blanda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast

(2013) Jaroslav Vecer et al.   FEBS LETTERS

Genetic Networks Inducing Invasive Growth in Saccharomyces cerevisiae Identified Through Systematic Genome-Wide Overexpression

(2013) C. A. Shively et al.   GENETICS

Sphingolipid Domains in the Plasma Membranes of Fibroblasts Are Not Enriched with Cholesterol

(2013) Jessica F. Frisz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orm Proteins Integrate Multiple Signals to Maintain Sphingolipid Homeostasis

(2013) Charulatha Gururaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells

(2013) Alexandre Toulmay et al.   JOURNAL OF CELL BIOLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts

(2013) J. F. Frisz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MARVEL Domain Protein Nce102 Regulates Actin Organization and Invasive Growth of Candida albicans

(2013) L. M. Douglas et al.   mBio

Rapid Redistribution of Phosphatidylinositol-(4,5)-Bisphosphate and Septins during the Candida albicans Response to Caspofungin

(2012) Hassan Badrane et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Zinc Cluster Protein Sut1 Contributes to Filamentation in Saccharomyces cerevisiae

(2012) Helen A. Foster et al.   EUKARYOTIC CELL

A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth

(2012) Aurélia Vernay et al.   JOURNAL OF CELL BIOLOGY

Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast

(2012) M. Liu et al.   JOURNAL OF CELL SCIENCE

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Patchwork organization of the yeast plasma membrane into numerous coexisting domains

(2012) Felix Spira et al.   NATURE CELL BIOLOGY

Distribution of Cortical Endoplasmic Reticulum Determines Positioning of Endocytic Events in Yeast Plasma Membrane

(2012) Vendula Stradalova et al.   PLoS One

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Convergences and divergences among eukaryotic kingdoms

(2012) Elise Delage et al.   PROGRESS IN LIPID RESEARCH

Identification,in VitroActivity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules

(2011) Bonnie K. Baxter et al.   ACS Chemical Biology

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Pil1, an eisosome organizer, plays an important role in the recruitment of synaptojanins and amphiphysins to facilitate receptor-mediated endocytosis in yeast

(2011) Erin R. Murphy et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Eisosome proteins assemble into a membrane scaffold

(2011) Lena Karotki et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

The eisosome core is composed of BAR domain proteins

(2011) Agustina Olivera-Couto et al.   MOLECULAR BIOLOGY OF THE CELL

The filament-forming protein Pil1 assembles linear eisosomes in fission yeast

(2011) Ruth Kabeche et al.   MOLECULAR BIOLOGY OF THE CELL

Eisosome-driven plasma membrane organization is mediated by BAR domains

(2011) Natasza E Ziółkowska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sur7 Promotes Plasma Membrane Organization and Is Needed for Resistance to Stressful Conditions and to the Invasive Growth and Virulence of Candida albicans

(2011) L. M. Douglas et al.   mBio

Lateral reorganization of plasma membrane is involved in the yeast resistance to severe dehydration

(2010) Sebastien Dupont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae

(2010) Ma Carmen García-López et al.   CURRENT GENETICS

C Terminus of Nce102 Determines the Structure and Function of Microdomains in the Saccharomyces cerevisiae Plasma Membrane

(2010) Martin Loibl et al.   EUKARYOTIC CELL

Gel Domains in the Plasma Membrane ofSaccharomyces cerevisiae

(2010) Francisco Aresta-Branco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Sphingolipid Metabolism by the Phosphatidylinositol-4-phosphate Phosphatase Sac1p through Regulation of Phosphatidylinositol inSaccharomyces cerevisiae

(2009) Sarah E. Brice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues

(2009) Timothy A. Schulz et al.   JOURNAL OF CELL BIOLOGY

A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling

(2009) Florian Fröhlich et al.   JOURNAL OF CELL BIOLOGY

Furrow-like invaginations of the yeast plasma membrane correspond to membrane compartment of Can1

(2009) V. Stradalova et al.   JOURNAL OF CELL SCIENCE

Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology

(2009) Xue Li Guan et al.   MOLECULAR BIOLOGY OF THE CELL

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

(2009) Doris Berchtold et al.   MOLECULAR BIOLOGY OF THE CELL

Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae

(2008) Nuno Pedroso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphatidic Acid Phosphatase, a Key Enzyme in the Regulation of Lipid Synthesis

(2008) George M. Carman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingolipid Long-chain Base-Pkh1/2-Ypk1/2 Signaling Pathway Regulates Eisosome Assembly and Turnover

(2008) Guangzuo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane microdomains regulate turnover of transport proteins in yeast

(2008) Guido Grossmann et al.   JOURNAL OF CELL BIOLOGY

The Sur7 Protein Regulates Plasma Membrane Organization and Prevents Intracellular Cell Wall Growth in Candida albicans

(2008) Francisco J. Alvarez et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY