Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase

(2015) Sunny S. Lou et al.   JOURNAL OF CELL BIOLOGY

Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation

(2015) Kazuya Tsujita et al.   NATURE CELL BIOLOGY

The TORC2 Component, Sin1, Controls Migration of Anterior Mesendoderm during Zebrafish Gastrulation

(2015) Julien G. Dumortier et al.   PLoS One

A large-scale screen reveals genes that mediate electrotaxis inDictyostelium discoideum

(2015) Runchi Gao et al.   Science Signaling

A large-scale screen reveals genes that mediate electrotaxis inDictyostelium discoideum

(2015) Runchi Gao et al.   Science Signaling

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

Membrane Tension in Rapidly Moving Cells Is Determined by Cytoskeletal Forces

(2013) Arnon D. Lieber et al.   CURRENT BIOLOGY

Ca2+ and calpain control membrane expansion during the rapid cell spreading of neutrophils

(2013) S. Dewitt et al.   JOURNAL OF CELL SCIENCE

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

(2013) Yuan He et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis

(2013) T. A. Masters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

(2013) M. Kampmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods

(2012) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing

(2012) D. Rosel et al.   JOURNAL OF CELL SCIENCE

Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging

(2012) A. Millius et al.   JOURNAL OF CELL SCIENCE

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical feedback between membrane tension and dynamics

(2012) Nils C. Gauthier et al.   TRENDS IN CELL BIOLOGY

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc -receptor-stimulated ROS production in neutrophils

(2011) L. J. Norton et al.   JOURNAL OF CELL SCIENCE

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

(2011) Michelle C. Mendoza et al.   MOLECULAR CELL

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

Membrane tension regulates motility by controlling lamellipodium organization

(2011) E. L. Batchelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading

(2011) N. C. Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab-Family GTPase Regulates TOR Complex 2 Signaling in Fission Yeast

(2010) Hisashi Tatebe et al.   CURRENT BIOLOGY

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

Phosphatidic Acid Is a Leukocyte Chemoattractant That Acts through S6 Kinase Signaling

(2010) Kathleen Frondorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2

(2010) Xin-Hua Liao et al.   JOURNAL OF CELL SCIENCE

Cells navigate with a local-excitation, global-inhibition-biased excitable network

(2010) Y. Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity

(2009) Robert Lavieri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biology and Physics of Cell Shape Changes in Development

(2009) Ewa Paluch et al.   CURRENT BIOLOGY

Adaptive force transmission in amoeboid cell migration

(2009) Jörg Renkawitz et al.   NATURE CELL BIOLOGY

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

(2008) Yoichiro Kamimura et al.   CURRENT BIOLOGY

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

A Lipid-signaled Myosin Phosphatase Surge Disperses Cortical Contractile Force Early in Cell Spreading

(2008) Guangwei Du et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of shape determination in motile cells

(2008) Kinneret Keren et al.   NATURE