Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

(2018) Chiara Ambrogio et al.   CELL

The Dictyostelium GSK3 kinase GlkA coordinates signal relay and chemotaxis in response to growth conditions

(2018) Jesus Lacal Romero et al.   DEVELOPMENTAL BIOLOGY

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

(2018) Saige L. Pompura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altering the threshold of an excitable signal transduction network changes cell migratory modes

(2017) Yuchuan Miao et al.   NATURE CELL BIOLOGY

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

(2016) H. Jang et al.   BIOCHEMICAL JOURNAL

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

(2016) Mark A. Lemmon et al.   CELL

The microfluidic lighthouse: an omnidirectional gradient generator

(2016) A. Nakajima et al.   LAB ON A CHIP

The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells

(2016) Hiroshi Senoo et al.   MOLECULAR BIOLOGY OF THE CELL

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The small GTPases Ras and Rap1 bind to and control TORC2 activity

(2016) Ankita Khanna et al.   Scientific Reports

Chemotaxis of a model organism: progress with Dictyostelium

(2015) John ME Nichols et al.   CURRENT OPINION IN CELL BIOLOGY

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Networks that Regulate Cell Migration

(2015) Peter Devreotes et al.   Cold Spring Harbor Perspectives in Biology

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

(2014) Yulia Artemenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rho GTPases orient directional sensing in chemotaxis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity

(2012) Günther Gerisch et al.   BIOPHYSICAL JOURNAL

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

(2012) Verena Kölsch et al.   MOLECULAR BIOLOGY OF THE CELL

Signaling mechanisms for chemotaxis

(2011) Yu Wang et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

(2010) Pascale G. Charest et al.   DEVELOPMENTAL CELL

Cellular responses to extracellular guidance cues

(2010) Anastacia Berzat et al.   EMBO JOURNAL

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2

(2010) Xin-Hua Liao et al.   JOURNAL OF CELL SCIENCE

Glycogen Synthase Kinase-3 Is Required for Efficient Dictyostelium Chemotaxis

(2010) Regina Teo et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

(2010) Ming Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Utilization of Arg-elution method for FLAG-tag based chromatography

(2009) Mutsumi Futatsumori-Sugai et al.   PROTEIN EXPRESSION AND PURIFICATION

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

(2008) Arjan Kortholt et al.   CELLULAR SIGNALLING

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

(2008) Yoichiro Kamimura et al.   CURRENT BIOLOGY

Crosstalk between small GTPases and polarity proteins in cell polarization

(2008) Sandra Iden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY