Rab5 GTPases are required for optimal TORC2 function

TOR Complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites

(2018) Françoise M. Roelants et al.   MOLECULAR BIOLOGY OF THE CELL

AGC kinases, mechanisms of regulation ‎and innovative drug development

(2018) Alejandro E. Leroux et al.   SEMINARS IN CANCER BIOLOGY

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2

(2018) Kristin L. Leskoske et al.   GENES & DEVELOPMENT

Regulation of Rab5 isoforms by transcriptional and post-transcriptional mechanisms in yeast

(2017) Oliver Schmidt et al.   FEBS LETTERS

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae

(2017) Françoise M. Roelants et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

(2017) Manikandan Karuppasamy et al.   Nature Communications

Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation

(2017) Chien-An Yao et al.   Oncotarget

Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

(2017) Hisashi Tatebe et al.   eLife

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress

(2016) J. F. Guerreiro et al.   BIOCHEMICAL JOURNAL

Cell surface recycling in yeast: mechanisms and machineries

(2016) Chris MacDonald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae

(2016) Christopher G. Alvaro et al.   GENETICS

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex

(2016) Evan L. Guiney et al.   MOLECULAR BIOLOGY OF THE CELL

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae

(2016) Christopher G. Alvaro et al.   GENETICS

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

(2016) Katie Powis et al.   Cell Discovery

Control of Plasma Membrane Permeability by ABC Transporters

(2015) Svetlana Khakhina et al.   EUKARYOTIC CELL

Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model

(2015) Serge Feyder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dexamethasone-induced cellular tension requires a SGK1-stimulated Sec5-GEF-H1 interaction

(2015) H.-L. Wang et al.   JOURNAL OF CELL SCIENCE

Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes

(2015) Bjorn D. M. Bean et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9

(2015) Tess Shideler et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of an oncogenic RAB protein

(2015) D. B. Wheeler et al.   SCIENCE

Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

(2015) Alexander Muir et al.   eLife

Fungal Membrane Organization: The Eisosome Concept

(2014) Lois M. Douglas et al.   Annual Review of Microbiology

The Nutrient Stress-induced Small GTPase Rab5 Contributes to the Activation of Vesicle Trafficking and Vacuolar Activity

(2014) Kunio Nakatsukasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

Guanine Nucleotide Exchange Factors (GEFs) Have a Critical but Not Exclusive Role in Organelle Localization of Rab GTPases

(2013) Margarita Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vps9 Family Protein Muk1 Is the Second Rab5 Guanosine Nucleotide Exchange Factor in Budding Yeast

(2013) Andrew L. Paulsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient regulation of the mTOR Complex 1 signaling pathway

(2013) Sang Gyun Kim et al.   MOLECULES AND CELLS

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

(2013) Danielle L Swaney et al.   NATURE METHODS

A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum

(2013) Nathan C Shaner et al.   NATURE METHODS

Rab GAP cascade regulates dynamics of Ypt6 in the Golgi traffic

(2013) Y. Suda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OptimizedE. coliexpression strain LOBSTR eliminates common contaminants from His-tag purification

(2013) Kasper R. Andersen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Nutrient signaling to mTOR and cell growth

(2013) Jenna L. Jewell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

(2013) Joseph I. Kliegman et al.   Cell Reports

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae

(2012) Qingsong Liu et al.   ACS Chemical Biology

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles

(2012) Jens Lachmann et al.   MOLECULAR BIOLOGY OF THE CELL

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Termination of Isoform-Selective Vps21/Rab5 Signaling at Endolysosomal Organelles by Msb3/Gyp3

(2012) Daniel P. Nickerson et al.   TRAFFIC

Target of Rapamycin Complex 2 Signals to Downstream Effector Yeast Protein Kinase 2 (Ypk2) through Adheres-Voraciously-to-Target-of-Rapamycin-2 Protein 1 (Avo1) inSaccharomyces cerevisiae

(2011) Hsien-Ching Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic

(2011) Rachael L. Plemel et al.   MOLECULAR BIOLOGY OF THE CELL

Intrinsic tethering activity of endosomal Rab proteins

(2011) Sheng-Ying Lo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab-Family GTPase Regulates TOR Complex 2 Signaling in Fission Yeast

(2010) Hisashi Tatebe et al.   CURRENT BIOLOGY

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

(2010) J. Mok et al.   Science Signaling

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1

(2009) Joseph Avruch et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rag proteins regulate amino-acid-induced mTORC1 signalling

(2009) Yasemin Sancak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Visualization of molecular interactions using bimolecular fluorescence complementation analysis: Characteristics of protein fragment complementation

(2009) Tom K. Kerppola   CHEMICAL SOCIETY REVIEWS

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

(2009) Doris Berchtold et al.   MOLECULAR BIOLOGY OF THE CELL

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

Long QT Syndrome–Associated Mutations in KCNQ1 and KCNE1 Subunits Disrupt Normal Endosomal Recycling of I Ks Channels

(2008) Guiscard Seebohm et al.   CIRCULATION RESEARCH

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

(2008) Claudio P. Albuquerque et al.   MOLECULAR & CELLULAR PROTEOMICS

Stress resistance and signal fidelity independent of nuclear MAPK function

(2008) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA