Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

An integrated view on a eukaryotic osmoregulation system

(2015) Stefan Hohmann   CURRENT GENETICS

A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae

(2015) Mandy Hiu Yi Lam et al.   JOURNAL OF MOLECULAR BIOLOGY

Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress

(2015) Evan L. Guiney et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation

(2015) Evgeny Kanshin et al.   Cell Reports

Rewiring yeast osmostress signalling through the MAPK network reveals essential and non-essential roles of Hog1 in osmoadaptation

(2014) Roja Babazadeh et al.   Scientific Reports

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators

(2013) J. Lee et al.   GENES & DEVELOPMENT

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

(2013) Joseph I. Kliegman et al.   Cell Reports

Response to Hyperosmotic Stress

(2012) H. Saito et al.   GENETICS

Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae

(2012) Susan A. Henry et al.   GENETICS

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo measurement of signaling cascade dynamics

(2011) Megan N. McClean et al.   CELL CYCLE

Target of Rapamycin Complex 2 Signals to Downstream Effector Yeast Protein Kinase 2 (Ypk2) through Adheres-Voraciously-to-Target-of-Rapamycin-2 Protein 1 (Avo1) inSaccharomyces cerevisiae

(2011) Hsien-Ching Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Controlling gene expression in response to stress

(2011) Eulàlia de Nadal et al.   NATURE REVIEWS GENETICS

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Positive Regulators of the Yeast Fps1 Glycerol Channel

(2009) Sara E. Beese et al.   PLoS Genetics

Signal processing by the HOG MAP kinase pathway

(2008) P. Hersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress resistance and signal fidelity independent of nuclear MAPK function

(2008) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA