The power from within – understanding the driving forces of neutrophil extracellular trap formation

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs

(2019) Malgorzata J. Podolska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation

(2019) Luise Erpenbeck et al.   Frontiers in Immunology

The double-edged role of neutrophil extracellular traps in inflammation

(2019) Maximilien Euler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Blue and Long-Wave Ultraviolet Light Induce in vitro Neutrophil Extracellular Trap (NET) Formation

(2019) Elsa Neubert et al.   Frontiers in Immunology

Neutrophils: multitasking first responders of immunity and tissue homeostasis

(2018) Craig N. Jenne et al.   CELL AND TISSUE RESEARCH

The enigmatic neutrophil: what we do not know

(2018) Paul Kubes   CELL AND TISSUE RESEARCH

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

Neutrophil Extracellular Traps in the Second Decade

(2018) Volker Brinkmann   Journal of Innate Immunity

Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions

(2018) X. Yu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone

(2018) Cristiane Naffah de Souza et al.   Frontiers in Immunology

Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation

(2018) Cynthia M. de Bont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

(2018) Jonas Hahn et al.   FASEB JOURNAL

Recent advances on the crosstalk between neutrophils and B or T lymphocytes

(2018) Sara Costa et al.   IMMUNOLOGY

Chromatin swelling drives neutrophil extracellular trap release

(2018) Elsa Neubert et al.   Nature Communications

The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function

(2018) Harriet R. Manley et al.   Frontiers in Immunology

Neutrophils in Homeostasis, Immunity, and Cancer

(2017) José Ángel Nicolás-Ávila et al.   IMMUNITY

Increased levels of neutrophil extracellular trap remnants in the serum of patients with rheumatoid arthritis

(2017) Wei Wang et al.   International Journal of Rheumatic Diseases

Activated protein C inhibits neutrophil extracellular trap formationin vitroand activationin vivo

(2017) Laura D. Healy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Extracellular Traps: A Scoping Review

(2017) Ryan S. Doster et al.   Journal of Innate Immunity

Granulocytes as modulators of dendritic cell function

(2017) Annelot Breedveld et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review

(2017) Tamara Hoppenbrouwers et al.   PLoS One

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps

(2017) Martina Behnen et al.   Frontiers in Immunology

Granulocytes: New Members of the Antigen-Presenting Cell Family

(2017) Ang Lin et al.   Frontiers in Immunology

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging

(2017) Maarten van der Linden et al.   Scientific Reports

PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model

(2016) L. Erpenbeck et al.   BIOLOGY OF REPRODUCTION

Matters of life and death. How neutrophils die or survive along NET release and is “NETosis” = necroptosis?

(2016) Jyaysi Desai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interindividual variation of NETosis in healthy donors: introduction and application of a refined method for extracellular trap quantification

(2016) Jochen H. O. Hoffmann et al.   EXPERIMENTAL DERMATOLOGY

Histones as mediators of host defense, inflammation and thrombosis

(2016) Marloes Hoeksema et al.   Future Microbiology

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

(2016) Kimberly Martinod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Conservative Mechanisms of Extracellular Trap Formation by Annelida Eisenia andrei: Serine Protease Activity Requirement

(2016) Joanna Homa et al.   PLoS One

The lymph node neutrophil

(2016) Henry R. Hampton et al.   SEMINARS IN IMMUNOLOGY

Social amoebae trap and kill bacteria by casting DNA nets

(2016) Xuezhi Zhang et al.   Nature Communications

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host

(2016) Maren von Köckritz-Blickwede et al.   Frontiers in Microbiology

Neutrophil Integrins and Matrix Ligands and NET Release

(2016) Xian M. O’Brien et al.   Frontiers in Immunology

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis

(2016) Andrew S. Kimball et al.   Frontiers in Immunology

Entamoeba histolytica Trophozoites and Lipopeptidophosphoglycan Trigger Human Neutrophil Extracellular Traps

(2016) Eva E. Ávila et al.   PLoS One

A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa

(2015) T. Mohanty et al.   BLOOD

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps

(2015) Tyler W.R. Halverson et al.   PLoS Pathogens

How Neutrophils Shape Adaptive Immune Responses

(2015) Pieter H. C. Leliefeld et al.   Frontiers in Immunology

Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease

(2014) S. Tibrewal et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

(2014) Chanchal Sur Chowdhury et al.   ARTHRITIS RESEARCH & THERAPY

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Adhesion Maturation of Neutrophils on Nanoscopically Presented Platelet Glycoprotein Ibα

(2013) Sebastian Kruss et al.   ACS Nano

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity

(2013) Nishant Dwivedi et al.   ANNALS OF THE RHEUMATIC DISEASES

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

(2013) Ka-Wing Wong et al.   JOURNAL OF INFECTIOUS DISEASES

Is DNA a Good Model Polymer?

(2013) Douglas R. Tree et al.   MACROMOLECULES

Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

(2013) Anthony J. O’Donoghue et al.   PLoS One

Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

(2013) Jonatan Leffler et al.   ARTHRITIS RESEARCH & THERAPY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies

(2012) Sebastian Kruss et al.   LAB ON A CHIP

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Radius of gyration of plasmid DNA isoforms from static light scattering

(2010) David R. Latulippe et al.   BIOTECHNOLOGY AND BIOENGINEERING

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

(2010) Martin P. Stewart et al.   NATURE

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Extracellular DNA Is Required for Root Tip Resistance to Fungal Infection

(2009) F. Wen et al.   PLANT PHYSIOLOGY

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition

(2008) A OLINS et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The LINC-less granulocyte nucleus

(2008) Ada L. Olins et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE