Histones as mediators of host defense, inflammation and thrombosis

FAF and SufA: Proteins of Finegoldia magna That Modulate the Antibacterial Activity of Histones

(2017) Elizabeth C. Murphy et al.   Journal of Innate Immunity

Inter-  inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

(2015) H. Chaaban et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Arginine-rich histones have strong antiviral activity for influenza A viruses

(2015) Marloes Hoeksema et al.   Innate Immunity

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?

(2015) Craig N. Jenne et al.   PLoS Pathogens

DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps

(2015) Tyler W.R. Halverson et al.   PLoS Pathogens

Modular analysis of hipposin, a histone-derived antimicrobial peptide consisting of membrane translocating and membrane permeabilizing fragments

(2014) Maria E. Bustillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

(2014) Nishant Dwivedi et al.   FASEB JOURNAL

Proteases, neutrophils, and periodontitis: the NET effect

(2014) William M. Nauseef   JOURNAL OF CLINICAL INVESTIGATION

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

LL-37 modulates human neutrophil responses to influenza A virus

(2014) Shweta Tripathi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic inheritance uncoupled from sequence-specific recruitment

(2014) K. Ragunathan et al.   SCIENCE

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

The amazing innate immune response to influenza A virus infection

(2013) Shweta Tripathi et al.   Innate Immunity

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Human CRP Defends against the Toxicity of Circulating Histones

(2013) S. T. Abrams et al.   JOURNAL OF IMMUNOLOGY

Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus

(2013) Shuu Morita et al.   PEPTIDES

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fighting against the dark side of neutrophil extracellular traps in disease

(2012) Mona Saffarzadeh et al.   CURRENT OPINION IN HEMATOLOGY

Platelet-neutrophil Interactions as a Target for Prevention and Treatment of Transfusion- related Acute Lung Injury

(2012) Axelle Caudrillier et al.   CURRENT PHARMACEUTICAL DESIGN

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition

(2012) Ravi S. Keshari et al.   PLoS One

A novel role for lipid droplets in the organismal antibacterial response

(2012) Preetha Anand et al.   eLife

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antimicrobial properties of arginine- and lysine-rich histones and involvement of bacterial outer membrane protease T in their differential mode of actions

(2011) Chihiro Tagai et al.   PEPTIDES

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Differential Microbicidal Effects of Human Histone Proteins H2A and H2B onLeishmaniaPromastigotes and Amastigotes

(2010) Yingwei Wang et al.   INFECTION AND IMMUNITY

Review: Defensins and cathelicidins in lung immunity

(2010) Tesfaldet Tecle et al.   Innate Immunity

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H4 Is a Major Component of the Antimicrobial Action of Human Sebocytes

(2009) Dong-Youn Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Extrachromosomal Histone H2B Mediates Innate Antiviral Immune Responses Induced by Intracellular Double-Stranded DNA

(2009) K. Kobiyama et al.   JOURNAL OF VIROLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

(2009) Jan-Michel Otte et al.   REGULATORY PEPTIDES

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Buforins: Histone H2A-derived antimicrobial peptides from toad stomach

(2008) Ju Hyun Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial effects of H4-(86-100), histogranin and related compounds - possible involvement of DNA gyrase

(2008) Simon Lemaire et al.   FEBS Journal

Investigating the nucleic acid interactions and antimicrobial mechanism of buforin II

(2008) Erika T. Uyterhoeven et al.   FEBS LETTERS

Structure–activity relations of parasin I, a histone H2A-derived antimicrobial peptide

(2008) Young Sook Koo et al.   PEPTIDES

Characterization of a hemolytic protein, identified as histone H4, from the skin of the Japanese tree frog Hyla japonica (Hylidae)

(2007) Hiroaki Kawasaki et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37

(2007) Marta Carretero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY