Activated protein C inhibits neutrophil extracellular trap formationin vitroand activationin vivo

Protease-activated receptors in hemostasis

(2016) M. T. Nieman   BLOOD

Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform

(2016) Laura D. Healy et al.   JOURNAL OF IMMUNOLOGICAL METHODS

3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

(2016) Yaoming Wang et al.   NATURE MEDICINE

Activated protein C: biased for translation

(2015) J. H. Griffin et al.   BLOOD

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

(2015) H. P. H. Liang et al.   BLOOD

The emerging role of coagulation proteases in kidney disease

(2015) Thati Madhusudhan et al.   Nature Reviews Nephrology

The effect of plasma-derived activated protein C on leukocyte cell-death and vascular endothelial damage

(2015) Toshiaki Iba et al.   THROMBOSIS RESEARCH

Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

(2014) F. Stavenuiter et al.   BLOOD

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

(2014) Patrick Lyden et al.   CURRENT PHARMACEUTICAL DESIGN

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy

(2013) Asako Itakura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

(2013) Robert D Gray et al.   Journal of Inflammation-London

Mac-1 Directly Binds to the Endothelial Protein C-Receptor: A Link between the Protein C Anticoagulant Pathway and Inflammation?

(2013) Katrin Fink et al.   PLoS One

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils

(2013) Asako Itakura et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

(2012) E. I. Tucker et al.   BLOOD

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove

(2011) J. Lopez-Sagaseta et al.   BLOOD

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

(2011) T. Madhusudhan et al.   BLOOD

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

(2010) A.R. Rezaie   CURRENT MEDICINAL CHEMISTRY

Proteinase-activated receptor-2 up-regulation by Fcγ-receptor activation in human neutrophils

(2010) Mireille St-Onge et al.   FASEB JOURNAL

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va

(2010) Andrew J. Gale et al.   PROTEIN SCIENCE

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Recombinant human activated protein C inhibits integrin-mediated neutrophil migration

(2009) G. F. Elphick et al.   BLOOD

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

(2009) Huang Guo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement

(2008) Shona Harmon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY