Granulopoiesis and granules of human neutrophils

The Branching Point in Erythro-Myeloid Differentiation

(2015) Leïla Perié et al.   CELL

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

(2015) Franziska Paul et al.   CELL

Analysis of site-specificN-glycan remodeling in the endoplasmic reticulum and the Golgi

(2015) Ivan Hang et al.   GLYCOBIOLOGY

Human Neutrophils Secrete Bioactive Paucimannosidic Proteins from Azurophilic Granules into Pathogen-Infected Sputum

(2015) Morten Thaysen-Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer

(2015) Stine N. Clemmensen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency

(2015) Taizo Wada et al.   JOURNAL OF IMMUNOLOGY

Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

(2015) Agne Malki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations

(2015) Yunfang Li et al.   PLoS Genetics

miRNA-130a regulates C/EBP-  expression during granulopoiesis

(2014) M. T. Larsen et al.   BLOOD

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Rab27a Regulates Exocytosis of Tertiary and Specific Granules in Human Neutrophils

(2014) M. J. Herrero-Turrion et al.   JOURNAL OF IMMUNOLOGY

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Differential Expression of Granulopoiesis Related Genes in Neutrophil Subsets Distinguished by Membrane Expression of CD177

(2014) Nan Hu et al.   PLoS One

ProHNPs are specific markers of normal myelopoiesis

(2014) F Emmertsen et al.   Blood Cancer Journal

Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly

(2014) Asma Rehman et al.   IUCrJ

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

(2013) N. Rapin et al.   BLOOD

Surface receptor CD177/NB1 does not confer a recruitment advantage to neutrophilic granulocytes during human peritonitis

(2013) Le Wang et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease

(2013) Wenli Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity

(2013) N. C. Perera et al.   JOURNAL OF IMMUNOLOGY

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

MicroRNA Profiling in Human Neutrophils during Bone Marrow Granulopoiesis and In Vivo Exudation

(2013) Maria T. Larsen et al.   PLoS One

The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In Vitro

(2013) Amanda Welin et al.   PLoS One

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

(2012) H. Guo et al.   BLOOD

Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice

(2012) M. F. Alemdehy et al.   BLOOD

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion

(2012) Eric R. Lechman et al.   Cell Stem Cell

Olfactomedin 4 Inhibits Cathepsin C-Mediated Protease Activities, Thereby Modulating Neutrophil Killing of Staphylococcus aureus and Escherichia coli in Mice

(2012) W. Liu et al.   JOURNAL OF IMMUNOLOGY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

MicroRNA-130a-mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF- 1 stimulation in granulocytic precursors

(2011) M. Hager et al.   BLOOD

Serglycin participates in retention of  -defensin in granules during myelopoiesis

(2011) A. Glenthoj et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis

(2011) Stine N. Clemmensen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Technical Advance: Immunophenotypical characterization of human neutrophil differentiation

(2011) Helena Mora-Jensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Olfactomedin 4 defines a subset of human neutrophils

(2011) Stine N. Clemmensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of Smad signaling in hematopoiesis and translational hematology

(2011) U Blank et al.   LEUKEMIA

C/EBP  regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations

(2010) J. A. Pulikkan et al.   BLOOD

Dual granule localization of the dormant NADPH oxidase and cytochrome b559 in human neutrophils

(2010) O. W. Bjerrum et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Intracellular location of syntaxin 7 in human neutrophils

(2010) Li-xin Xie et al.   IMMUNOLOGY LETTERS

Complement Receptor Mac-1 Is an Adaptor for NB1 (CD177)-mediated PR3-ANCA Neutrophil Activation

(2010) Uwe Jerke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by the Endothelial S536N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1

(2010) B. Bayat et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection

(2010) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Hematopoietic Stem Cell-Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy

(2010) B. Gentner et al.   Science Translational Medicine

Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia

(2009) J. A. Pulikkan et al.   BLOOD

Gfi1 regulates miR-21 and miR-196b to control myelopoiesis

(2009) Chinavenmeni S. Velu et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling

(2008) Troy Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils

(2008) Cristiana Brochetta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lineage development of hematopoietic stem and progenitor cells

(2008) Bernd Giebel et al.   BIOLOGICAL CHEMISTRY

TGF-  as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

(2008) S. Yamazaki et al.   BLOOD

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE