The role of neutrophils and NETosis in autoimmune and renal diseases

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction after Lung Transplantation

(2015) David M. Sayah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetics changes associated to environmental triggers in autoimmunity

(2015) Carlos A. Cañas et al.   AUTOIMMUNITY

Interaction of kindlin-3 and  2-integrins differentially regulates neutrophil recruitment and NET release in mice

(2015) Z. Xu et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

Neutrophil extracellular trap formation is associated with autophagy-related signalling in ANCA-associated vasculitis

(2015) S. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysis of 65 Renal Biopsies From Patients With Rheumatoid Arthritis (1976–2015)

(2015) Juan P. Vinicki et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis

(2015) Kim M. O’Sullivan et al.   KIDNEY INTERNATIONAL

Identification of a large set of rare complete human knockouts

(2015) Patrick Sulem et al.   NATURE GENETICS

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis

(2015) Go Kanzaki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased levels of neutrophil extracellular trap remnants in the circulation of patients with small vessel vasculitis, but an inverse correlation to anti-neutrophil cytoplasmic antibodies during remission

(2015) Daniel Söderberg et al.   RHEUMATOLOGY

Promotion of Hypercoagulability in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis by C5a-Induced Tissue Factor-Expressing Microparticles and Neutrophil Extracellular Traps

(2015) Yi-Min Huang et al.   Arthritis & Rheumatology

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase

(2015) Dragana Odobasic et al.   Arthritis & Rheumatology

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome

(2015) Srilakshmi Yalavarthi et al.   Arthritis & Rheumatology

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

The Balancing Act of Neutrophils

(2014) Bart W. Bardoel et al.   Cell Host & Microbe

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes

(2014) Y. Wang et al.   DIABETES

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps Downregulate Lipopolysaccharide-Induced Activation of Monocyte-Derived Dendritic Cells

(2014) Lorena Barrientos et al.   JOURNAL OF IMMUNOLOGY

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

(2014) Martina Behnen et al.   JOURNAL OF IMMUNOLOGY

CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN

(2014) E. M. Disteldorf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Enhanced Formation and Disordered Regulation of NETs in Myeloperoxidase-ANCA-Associated Microscopic Polyangiitis

(2014) D. Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis

(2014) Joshua D. Ooi et al.   KIDNEY INTERNATIONAL

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Renal involvement in antiphospholipid syndrome

(2014) Savino Sciascia et al.   Nature Reviews Nephrology

Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease

(2014) J. Charles Jennette et al.   Nature Reviews Rheumatology

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

Inhibition of HumanγδT Cell Proliferation and Effector Functions by Neutrophil Serine Proteases

(2014) J. Fazio et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Early diabetic nephropathy in type 1 diabetes

(2014) Petter Bjornstad et al.   Current Opinion in Endocrinology Diabetes and Obesity

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

(2014) Nathan L. Bowers et al.   PLoS Pathogens

Neutrophil Extracellular Trap-Derived Enzymes Oxidize High-Density Lipoprotein: An Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus

(2014) Carolyne K. Smith et al.   Arthritis & Rheumatology

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Attention Deficit and Hyperactivity Disorder Scores Are Elevated and Respond toN-Acetylcysteine Treatment in Patients With Systemic Lupus Erythematosus

(2013) Ricardo J. Garcia et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Citrullination Within the Atherosclerotic Plaque: A Potential Target for the Anti-Citrullinated Protein Antibody Response in Rheumatoid Arthritis

(2013) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Reduced Blood Leukocyte and Neutrophil Numbers in the Pathogenesis of Type 1 Diabetes

(2013) M. Harsunen et al.   HORMONE AND METABOLIC RESEARCH

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

Integrin Regulation during Leukocyte Recruitment

(2013) J. Herter et al.   JOURNAL OF IMMUNOLOGY

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis

(2013) Ruth J. Pepper et al.   KIDNEY INTERNATIONAL

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

The Pathogenesis of the Antiphospholipid Syndrome

(2013) Bill Giannakopoulos et al.   NEW ENGLAND JOURNAL OF MEDICINE

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

(2013) Jonatan Leffler et al.   ARTHRITIS RESEARCH & THERAPY

Granulocyte colony stimulating factor exacerbates antineutrophil cytoplasmic antibody vasculitis

(2012) Simon J Freeley et al.   ANNALS OF THE RHEUMATIC DISEASES

Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: Implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculiti

(2012) Daigo Nakazawa et al.   ARTHRITIS AND RHEUMATISM

The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin

(2012) Joyce J. B. C. van Beers et al.   ARTHRITIS AND RHEUMATISM

2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

(2012) J. C. Jennette et al.   ARTHRITIS AND RHEUMATISM

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Interleukin-17 Cytokines Are Critical in Development of Fatal Lupus Glomerulonephritis

(2012) Prapaporn Pisitkun et al.   IMMUNITY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition

(2012) Ravi S. Keshari et al.   PLoS One

The emerging role of neutrophils in thrombosis—the journey of TF through NETs

(2012) Konstantinos Kambas et al.   Frontiers in Immunology

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Hypochlorous acid regulates neutrophil extracellular trap release in humans

(2011) L. J. Palmer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Efficacy and safety of tacrolimus therapy for lupus nephritis: a systematic review of clinical trials

(2011) YH Lee et al.   LUPUS

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants

(2010) C.-W. Yang et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Cyclosporine A or intravenous cyclophosphamide for lupus nephritis: the Cyclofa-Lune study

(2010) J. Zavada et al.   LUPUS

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis

(2010) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation

(2010) Satyananda Patel et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Neutrophils: game changers in glomerulonephritis?

(2010) Tanya N. Mayadas et al.   TRENDS IN MOLECULAR MEDICINE

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies

(2009) Maria G. Tektonidou et al.   ARTHRITIS AND RHEUMATISM

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Mac-1 (CD11b/CD18) Links Inflammation and Thrombosis After Glomerular Injury

(2009) Junichi Hirahashi et al.   CIRCULATION

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

Role of neutrophils in innate immunity: a systems biology-level approach

(2009) Scott D. Kobayashi et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Human Neutrophil Fcγ Receptors Initiate and Play Specialized Nonredundant Roles in Antibody-Mediated Inflammatory Diseases

(2008) Naotake Tsuboi et al.   IMMUNITY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

(2008) Victoria Ramos-Kichik et al.   TUBERCULOSIS

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

(2008) Brian A Kidd et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

(2007) Patrizia Scapini et al.   IMMUNOLOGY LETTERS