Understanding the Pathophysiology of Cerebral Amyloid Angiopathy

In vivo characterization of spontaneous microhemorrhage formation in mice with cerebral amyloid angiopathy

(2020) Susanne J van Veluw et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

(2020) Jerome Robert et al.   Molecular Neurodegeneration

Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project

(2020) Anna Bersano et al.   NEUROLOGICAL SCIENCES

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

(2019) Gargi Banerjee et al.   ANNALS OF NEUROLOGY

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

(2019) Susan A Austin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

(2019) Yingjian You et al.   Acta Neuropathologica Communications

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

(2019) Yoshinori Endo et al.   Acta Neuropathologica Communications

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

(2019) Claire Leurent et al.   Annals of Clinical and Translational Neurology

Multiple Approaches to Diffusion Magnetic Resonance Imaging in Hereditary Cerebral Amyloid Angiopathy Mutation Carriers

(2019) Tijn M. Schouten et al.   Journal of the American Heart Association

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

(2019) Emily B. Button et al.   Alzheimers Research & Therapy

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42

(2019) Giorgio Giaccone et al.   Acta Neuropathologica Communications

Early Aβ reduction prevents progression of cerebral amyloid angiopathy

(2019) Juliane Schelle et al.   ANNALS OF NEUROLOGY

Amyloid Imaging of Dutch‐type Hereditary Cerebral Amyloid Angiopathy Carriers

(2019) Aaron Schultz et al.   ANNALS OF NEUROLOGY

HDL from an Alzheimerʼs disease perspective

(2019) Emily B. Button et al.   CURRENT OPINION IN LIPIDOLOGY

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

(2019) Shereen Nizari et al.   Frontiers in Aging Neuroscience

Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2α–ATF4 Pathway in Mouse Microglia

(2019) Takayuki Inoue et al.   Cells

Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer’s Disease

(2019) Baruh Polis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy

(2019) Neethu Michael et al.   Frontiers in Neurology

Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy

(2019) Andreas Charidimou et al.   NEUROLOGY

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery

(2018) Zane Jaunmuktane et al.   ACTA NEUROPATHOLOGICA

Fatal Aβ cerebral amyloid angiopathy 4 decades after a dural graft at the age of 2 years

(2018) Dominique Hervé et al.   ACTA NEUROPATHOLOGICA

Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

(2018) David M. A. Mann et al.   ACTA NEUROPATHOLOGICA

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

(2018) Nina Schultz et al.   AGING CELL

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

Prions, prionoids and protein misfolding disorders

(2018) Claudia Scheckel et al.   NATURE REVIEWS GENETICS

The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier

(2018) Shino Magaki et al.   NEUROBIOLOGY OF AGING

Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy

(2018) Andreas Charidimou et al.   NEUROLOGY

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

(2018) Xiaoting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis of Cerebral Amyloid Angiopathy

(2018) Steven M. Greenberg et al.   STROKE

Molecular subtypes of Alzheimer’s disease

(2018) Giuseppe Di Fede et al.   Scientific Reports

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

(2018) Michael Burwinkel et al.   Acta Neuropathologica Communications

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

(2018) Ignazio Cali et al.   Acta Neuropathologica Communications

Blocking the Apolipoprotein E/Amyloid-β Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice

(2018) Jing Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Primary Cerebral Blood Flow Deficiency and Alzheimer's Disease: Shadows and Lights

(2018) Marianna Mazza et al.   JOURNAL OF ALZHEIMERS DISEASE

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

(2018) Silvia A. Purro et al.   NATURE

Cerebral amyloid angiopathy as a cause of neurodegeneration

(2017) Eric E. Smith   JOURNAL OF NEUROCHEMISTRY

Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages

(2017) Rachita K. Sumbria et al.   Journal of Neuroinflammation

Meta-analysis methodology in the microbleeds field: The relevance of the clinical question and study quality in choosing the most appropriate model

(2017) Andreas Charidimou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Identification of post-translational modifications of Aβ peptide in platelet membranes from patients with cerebral amyloid angiopathy

(2017) Lin Song et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cerebrovascular function in presymptomatic and symptomatic individuals with hereditary cerebral amyloid angiopathy: a case-control study

(2017) Anna M van Opstal et al.   LANCET NEUROLOGY

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

(2017) Jérôme Robert et al.   Molecular Neurodegeneration

Intravenous treatment with human recombinant ApoA-I Milano reduces beta amyloid cerebral deposition in the APP23-transgenic mouse model of Alzheimer's disease

(2017) Sofía Fernández-de Retana et al.   NEUROBIOLOGY OF AGING

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Aβ seeds and prions: How close the fit?

(2017) Jay Rasmussen et al.   Prion

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

(2017) Jerome Robert et al.   eLife

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets

(2017) Xue-mei Qi et al.   Translational Neurodegeneration

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

(2017) Satoshi Saito et al.   Acta Neuropathologica Communications

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Apolipoprotein E/Amyloid β Binding by Peptoid CPO_Aβ17-21 P Ameliorates Alzheimer’s Disease Related Pathology and Cognitive Decline

(2017) Shan Liu et al.   Scientific Reports

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chronic Cerebral Hypoperfusion Accelerates Alzheimer’s Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model

(2016) Yun Zhai et al.   JOURNAL OF ALZHEIMERS DISEASE

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

β-Amyloid in CSF

(2016) Ellis S. van Etten et al.   NEUROLOGY

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Human prion diseases: surgical lessons learned from iatrogenic prion transmission

(2016) David J. Bonda et al.   Neurosurgical Focus

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

(2016) Maria del C. Valdés Hernández et al.   Brain and Behavior

Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage

(2015) Sergi Martinez-Ramirez et al.   Alzheimers & Dementia

Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity

(2015) Kelly R. Bales et al.   BRAIN

Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage

(2015) Alessandro Biffi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

(2015) Franziska Schmidt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model

(2015) Shu-Sheng Jiao et al.   NEUROTOXICITY RESEARCH

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

(2015) J. Claude Hemphill et al.   STROKE

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells

(2014) Takayuki Kimura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

­Classifying prion and prion-like phenomena

(2014) Djamel Harbi et al.   Prion

Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type

(2014) Juliette A. Kamp et al.   REVIEWS IN THE NEUROSCIENCES

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

(2014) Tiffany L Sudduth et al.   Alzheimers Research & Therapy

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

(2014) Takakuni Maki et al.   Annals of Clinical and Translational Neurology

Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: An in vitro model of cerebral amyloid angiopathy

(2013) Kazuhiro Hasegawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

(2013) Anna Carrano et al.   NEUROBIOLOGY OF AGING

White matter perivascular spaces: An MRI marker in pathology-proven cerebral amyloid angiopathy?

(2013) A. Charidimou et al.   NEUROLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology

(2012) Robert W. Mahley et al.   NEURON

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study

(2011) Alessandro Biffi et al.   LANCET NEUROLOGY

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Critical role of interfaces and agitation on the nucleation of Aβ amyloid fibrils at low concentrations of Aβ monomers

(2010) Akiyoshi Morinaga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

(2010) S. Kumar-Singh   GENES BRAIN AND BEHAVIOR

Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

(2010) Iliya Lefterov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship Between Low Levels of High-Density Lipoprotein Cholesterol and Dementia in the Elderly. The InChianti Study

(2010) G. Zuliani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Perindopril-Based Lowering of Blood Pressure on Intracerebral Hemorrhage Related to Amyloid Angiopathy

(2010) Hisatomi Arima et al.   STROKE

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

(2009) Tamas Revesz et al.   ACTA NEUROPATHOLOGICA

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

(2009) Leon M Tai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in anin VitroModel of the Blood-Brain Barrier Cells

(2008) Kaoru Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH

Cerebral Amyloid Angiopathy: Progressive Disruption of the Neurovascular Unit

(2008) G. J. Zipfel et al.   STROKE

Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: A potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease

(2007) Douglas G. Walker et al.   MICROVASCULAR RESEARCH

β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension

(2007) Maria Teresa Gentile et al.   NEUROBIOLOGY OF AGING

Charge Alterations of E22 Enhance the Pathogenic Properties of the Amyloid β-Protein

(2003) Jerry P. Melchor et al.   JOURNAL OF NEUROCHEMISTRY