Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease

(2016) Raj N. Kalaria   ACTA NEUROPATHOLOGICA

Interaction between cerebrovascular disease and Alzheimer pathology

(2016) Satoshi Saito et al.   CURRENT OPINION IN PSYCHIATRY

Influence of Low-Dose Aspirin on Cerebral Amyloid Angiopathy in Mice

(2016) Yorito Hattori et al.   JOURNAL OF ALZHEIMERS DISEASE

Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study

(2016) Solène Moulin et al.   LANCET NEUROLOGY

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

(2016) Ping Yang et al.   MOLECULES

Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment

(2016) Nevicia F. Case et al.   STROKE

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

(2016) Yorito Hattori et al.   Journal of the American Heart Association

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

(2015) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution

(2015) G.C. Chiang et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity

(2015) Kelly R. Bales et al.   BRAIN

Mild Cognitive Impairment: At the Crossroad of Neurodegeneration and Vascular Dysfunction

(2015) Satoshi Saito et al.   Current Alzheimer Research

A Novel Mouse Model of Subcortical Infarcts with Dementia

(2015) Y. Hattori et al.   JOURNAL OF NEUROSCIENCE

Anti-Glycation Activities of Phenolic Constituents from Silybum marianum (Milk Thistle) Flower in Vitro and on Human Explants

(2015) Seoungwoo Shin et al.   MOLECULES

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload

(2015) Haipeng Guo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease

(2015) Ajay Gupta et al.   Frontiers in Aging Neuroscience

Free Access to a Running-Wheel Advances the Phase of Behavioral and Physiological Circadian Rhythms and Peripheral Molecular Clocks in Mice

(2015) Yuki Yasumoto et al.   PLoS One

Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy

(2014) Y. D. Reijmer et al.   BRAIN

Outcome markers for clinical trials in cerebral amyloid angiopathy

(2014) Steven M Greenberg et al.   LANCET NEUROLOGY

Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice

(2014) James L. Searcy et al.   PLoS One

Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase

(2014) Yorito Hattori et al.   STROKE

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

New Therapeutic Approaches for Alzheimer’s Disease and Cerebral Amyloid Angiopathy

(2014) Satoshi Saito et al.   Frontiers in Aging Neuroscience

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

(2014) Takakuni Maki et al.   Annals of Clinical and Translational Neurology

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

(2013) Mizuho SATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

Dihydroquercetin: More than just an impurity?

(2012) Anita Elaine Weidmann   EUROPEAN JOURNAL OF PHARMACOLOGY

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

(2012) Laibaik Park et al.   STROKE

pCO2 and pH regulation of cerebral blood flow

(2012) SeongHun Yoon et al.   Frontiers in Physiology

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study

(2011) Lenore J. Launer et al.   ANNALS OF NEUROLOGY

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice

(2011) Mahito Yamada et al.   PLoS One

Measuring Circadian and Acute Light Responses in Mice using Wheel Running Activity

(2011) Tara A. LeGates et al.   Jove-Journal of Visualized Experiments

Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

(2010) Nakaba MURATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Milk thistle in liver diseases: past, present, future

(2010) Ludovico Abenavoli et al.   PHYTOTHERAPY RESEARCH

Inhibition of Advanced Glycation End Product Formation by Medicinal Plant Extracts Correlates with Phenolic Metabolites and Antioxidant Activity

(2010) Cory Harris et al.   PLANTA MEDICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review

(2009) Hannah AD Keage et al.   BMC Neurology

Oligomeric Aβ in Alzheimer's Disease: Relationship to Plaque and Tangle Pathology,APOEGenotype and Cerebral Amyloid Angiopathy

(2009) Zoë van Helmond et al.   BRAIN PATHOLOGY

The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds

(2009) Sean A. Hudson et al.   FEBS Journal

A highly sensitive and robust UPLC–MS with electrospray ionization method for quantitation of taxifolin in rat plasma

(2009) Xiaodan Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

(2008) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Verification of the Intermolecular Parallel β-Sheet in E22K-Aβ42 Aggregates by Solid-State NMR Using Rotational Resonance: Implications for the Supramolecular Arrangement of the Toxic Conformer of Aβ42

(2008) Yuichi MASUDA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

In vivo study of dihydroquercetin genotoxicity

(2008) A. K. Zhanataev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

The neuroprotective potential of flavonoids: a multiplicity of effects

(2008) David Vauzour et al.   Genes and Nutrition

Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-  Peptide, Partial Restoration via  -Secretase Inhibition

(2008) B. H. Han et al.   JOURNAL OF NEUROSCIENCE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY