The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

(2016) Moeko Noguchi-Shinohara et al.   JOURNAL OF ALZHEIMERS DISEASE

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

(2016) Jose M. Farfel et al.   NEUROLOGY

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function

(2016) Loic Auderset et al.   Stem Cells International

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

(2016) Maria I. Fonseca et al.   PLoS One

Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity

(2015) Kelly R. Bales et al.   BRAIN

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Cerebral amyloid angiopathy with and without hemorrhage: Evidence for different disease phenotypes

(2015) A. Charidimou et al.   NEUROLOGY

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases

(2015) Lucinda Craggs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy

(2014) Kenji Sakai et al.   ACTA NEUROPATHOLOGICA

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

(2014) Aaron H Burstein et al.   BMC Neurology

Cilostazol improves lymphatic function by inducing proliferation and stabilization of lymphatic endothelial cells

(2014) Takayuki Kimura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

PKCε Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Aβ Degradation in Brain Neurons

(2014) Chol Seung Lim et al.   PLoS One

New Therapeutic Approaches for Alzheimer’s Disease and Cerebral Amyloid Angiopathy

(2014) Satoshi Saito et al.   Frontiers in Aging Neuroscience

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

(2014) Takakuni Maki et al.   Annals of Clinical and Translational Neurology

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway

(2013) M. Jacquet et al.   JOURNAL OF IMMUNOLOGY

ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy

(2013) Anna Carrano et al.   NEUROBIOLOGY OF AGING

Cilostazol improves cognitive function in patients with mild cognitive impairment: a retrospective analysis

(2013) Akihiko Taguchi et al.   Psychogeriatrics

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

(2013) Nobuhisa Iwata et al.   Scientific Reports

Mannose-Binding Lectin Binds to Amyloid Protein and Modulates Inflammation

(2012) Mykol Larvie et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

(2012) Akihiko Hoshi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic variation at CR1 increases risk of cerebral amyloid angiopathy

(2012) A. Biffi et al.   NEUROLOGY

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

(2011) Harshvardhan Rolyan et al.   JOURNAL OF NEURAL TRANSMISSION

Fluid mechanics in the perivascular space

(2011) Peng Wang et al.   JOURNAL OF THEORETICAL BIOLOGY

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

CR1is associated with amyloid plaque burden and age-related cognitive decline

(2010) Lori B. Chibnik et al.   ANNALS OF NEUROLOGY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy

(2010) A. Biffi et al.   NEUROLOGY

LRP-1

(2010) Stéphane Dedieu et al.   Cell Adhesion & Migration

MAPK, β-amyloid and synaptic dysfunction: the role of RAGE

(2009) Nicola Origlia et al.   Expert Review of Neurotherapeutics

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: A potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease

(2007) Douglas G. Walker et al.   MICROVASCULAR RESEARCH

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY