The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

The Prostaglandin D2 Receptor CRTH2 Promotes IL-33–Induced ILC2 Accumulation in the Lung

(2020) Oyebola O. Oyesola et al.   JOURNAL OF IMMUNOLOGY

DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

(2019) Ruth Saunders et al.   Science Translational Medicine

Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function

(2019) Clare Hardman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients

(2019) Carla Winkler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The impact of the prostaglandin D 2 receptor 2 and its downstream effects on the pathophysiology of asthma

(2019) Christopher E. Brightling et al.   ALLERGY

Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D 2 and cysteinyl leukotrienes in allergic rhinitis

(2019) Ichiro Tojima et al.   ALLERGY

Stability of peripheral blood immune markers in patients with asthma

(2019) Nami Shrestha Palikhe et al.   Allergy Asthma and Clinical Immunology

Suppression of aspirin-mediated eosinophil activation by prostaglandin E2

(2019) Kavita Pal et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild‐to‐moderate asthma

(2019) Hector Ortega et al.   CLINICAL AND EXPERIMENTAL ALLERGY

NEW TREATMENTS FOR ASTHMA: FROM THE PATHOGENIC ROLE OF PROSTAGLANDIN D2 TO THE THERAPEUTIC EFFECTS OF FEVIPIPRANT

(2019) Corrado Pelaia et al.   PHARMACOLOGICAL RESEARCH

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

(2019) Stacy Gelhaus Wendell et al.   PHARMACOLOGICAL REVIEWS

A Phase 2a Study of DP2 antagonist GB001 for Asthma

(2019) Koichiro Asano et al.   Journal of Allergy and Clinical Immunology-In Practice

Prostaglandin D 2 receptors in human mast cells

(2019) Jiao Xia et al.   ALLERGY

Dendritic cells treated with a prostaglandin I2 analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice

(2019) Tzu-Hsuan Wong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prostaglandin E2 signal inhibits T regulatory cell differentiation during allergic rhinitis inflammation through EP4 receptor

(2019) Lisha Li et al.   World Allergy Organization Journal

Targeting the interleukin-4 and interleukin-13 pathways in severe asthma

(2018) Amit D. Parulekar et al.   CURRENT OPINION IN PULMONARY MEDICINE

Prostaglandin D 2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1

(2018) Bandar K. Baothman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fevipiprant in the treatment of asthma

(2018) Christobelle White et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T cell–intrinsic prostaglandin E 2 -EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation

(2018) Jinju Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E 2 suppresses human group 2 innate lymphoid cell function

(2018) Jovana Maric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology

(2018) Sachin K. Samuchiwal et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

(2018) Bart Hilvering et al.   Mucosal Immunology

Activating prostaglandin E2 receptor subtype EP4 increases secreted mucin from airway goblet cells

(2018) Tomohiro Akaba et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists in asthma: a systematic review and meta-analysis protocol

(2018) Wei Liu et al.   BMJ Open

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

(2018) Maria M. M. Kaisar et al.   PLOS BIOLOGY

Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling

(2018) Yu Zhou et al.   Frontiers in Immunology

Aspirin-Exacerbated Respiratory Disease

(2018) Andrew A. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of E-prostanoid receptors in nasal polyp tissues of smoking and nonsmoking patients with chronic rhinosinusitis

(2018) Li Xie et al.   PLoS One

Eicosanoid Control Over Antigen Presenting Cells in Asthma

(2018) Nincy Debeuf et al.   Frontiers in Immunology

Prostaglandin E2 decrease in induced sputum of hypersensitive asthmatics during oral challenge with aspirin

(2018) Lucyna Mastalerz et al.   ALLERGY

Fevipiprant, a DP2 receptor antagonist, inhibits eosinophil migration towards mast cells

(2018) Revital Shamri et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights

(2018) Daniel Elieh Ali Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives

(2018) Giancarlo Marone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

An evaluation of fevipiprant for the treatment of asthma: a promising new therapy?

(2018) Juan Carlos Murillo et al.   EXPERT OPINION ON PHARMACOTHERAPY

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

(2018) Jovana Maric et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2 in NSAID-exacerbated respiratory disease

(2018) Mark Rusznak et al.   Current Opinion in Allergy and Clinical Immunology

Fevipiprant, an oral prostaglandin DP2receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids

(2017) Eric D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

Introduction to “allergic inflammation”

(2017) Toshinori Nakayama   IMMUNOLOGICAL REVIEWS

Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease

(2017) Jacqueline J. Eastman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis

(2017) Min-Ju Seo et al.   PROGRESS IN LIPID RESEARCH

Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling

(2017) L. Machado-Carvalho et al.   RHINOLOGY

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

(2017) Erik Wambre et al.   Science Translational Medicine

Prostaglandin I2Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses

(2016) Weisong Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Emergence of Biomolecular Pathways to Define Novel Asthma Phenotypes. Type-2 Immunity and Beyond

(2016) Sally E. Wenzel   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Impaired E Prostanoid2Expression and Resistance to Prostaglandin E2in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease

(2016) Katherine N. Cahill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Elevated levels of circulating CD4+CRTh2+T cells characterize severe asthma

(2016) N. S. Palikhe et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

(2016) Maya R. Karta et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Lipid Mediators in Aspirin-Exacerbated Respiratory Disease

(2016) Andrew R. Parker et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Eosinophil production of prostaglandin D 2 in patients with aspirin-exacerbated respiratory disease

(2016) Xin Feng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

(2016) Alyssa Mitson-Salazar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin controls prostaglandin D 2 generation in patients with aspirin-exacerbated respiratory disease

(2016) Kathleen M. Buchheit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma

(2016) Veit J. Erpenbeck et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

(2016) Marek Sanak   Allergy Asthma & Immunology Research

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

(2016) Piotr Kuna et al.   Drug Design Development and Therapy

Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis

(2016) Ji Heui Kim et al.   Scientific Reports

Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts

(2016) Kengo Kanai et al.   ALLERGOLOGY INTERNATIONAL

Fevipiprant, a prostaglandin D 2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial

(2016) Sherif Gonem et al.   Lancet Respiratory Medicine

Prostaglandins E2 signal mediated by receptor subtype EP2 promotes IgE production in vivo and contributes to asthma development

(2016) Yuhan Gao et al.   Scientific Reports

Factors Driving the Aspirin Exacerbated Respiratory Disease Phenotype

(2015) John W. Steinke et al.   American Journal of Rhinology & Allergy

Expression Profiles of Prostaglandin E2 Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis

(2015) Li Xie et al.   American Journal of Rhinology & Allergy

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

(2015) Kohichi Kawahara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

D prostanoid receptor 2 (chemoattractant receptor–homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells

(2015) Sally E. Stinson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin D2: A dominant mediator of aspirin-exacerbated respiratory disease

(2015) Katherine N. Cahill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The PGE2–EP2–mast cell axis: An antiasthma mechanism

(2015) Rosa Torres et al.   MOLECULAR IMMUNOLOGY

Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment

(2015) Ian P. Hall et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Evaluation of eicosanoids in nasal lavage as biomarkers of inflammation in patients with allergic rhinitis

(2015) Maciej Ciebiada et al.   Archives of Medical Science

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459

(2014) R. Pettipher et al.   ALLERGY

Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics

(2014) Z. Diamant et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2 Inhibits Eosinophil Trafficking through E-Prostanoid 2 Receptors

(2014) E. M. Sturm et al.   JOURNAL OF IMMUNOLOGY

Expression of DP2 (CRTh2), a Prostaglandin D2 Receptor, in Human Mast Cells

(2014) Tae Chul Moon et al.   PLoS One

The role of prostaglandins in allergic lung inflammation and asthma

(2014) Dru Claar et al.   Expert Review of Respiratory Medicine

Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation

(2013) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells

(2013) Zbigniew Zasłona et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

(2013) Chengcan Yao et al.   Nature Communications

Effect of Prostaglandin E2 on Vascular Endothelial Growth Factor Production in Nasal Polyp Fibroblasts

(2013) Dong Yeol Han et al.   Allergy Asthma & Immunology Research

The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial

(2012) F. Horak et al.   ALLERGY

Differential Regulation of Airway Smooth Muscle Cell Migration by E-Prostanoid Receptor Subtypes

(2012) Hiromichi Aso et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

PGE2 receptor (EP4) agonists: Potent dilators of human bronchi and future asthma therapy?

(2012) C. Benyahia et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

EP4 receptor stimulation down-regulates human eosinophil function

(2011) Petra Luschnig-Schratl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity

(2011) T. S. Hallstrand et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors

(2011) Viktoria Konya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis

(2011) Daisuke Kajiwara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression of Arachidonate Metabolism Enzymes and Receptors in Nasal Polyps of Aspirin-Hypersensitive Asthmatics

(2011) Anna M. Adamusiak et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The regulation of CD4+ T cell immune responses toward Th2 cell development by prostaglandin E2

(2011) Yu-Shi Bao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Reduced expression of COXs and production of prostaglandin E2 in patients with nasal polyps with or without aspirin-intolerant asthma

(2011) Jordi Roca-Ferrer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

D-type prostanoid receptor enhances the signaling of chemoattractant receptor–homologous molecule expressed on TH2 cells

(2011) Miriam Sedej et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to InduceMUC5BGene Expression via d-Prostanoid Receptor Signaling

(2011) Yeon Ho Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells

(2011) L. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Eosinophils as a Novel Cell Source of Prostaglandin D2: Autocrine Role in Allergic Inflammation

(2011) T. Luna-Gomes et al.   JOURNAL OF IMMUNOLOGY

Inhibitory effect of prostaglandin I2 on bone marrow kinetics of eosinophils in the guinea pig

(2011) Eva M. Sturm et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs

(2011) Takeshi Nabe et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

EP4 receptor as a new target for bronchodilator therapy

(2011) J. Buckley et al.   THORAX

Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa

(2010) Hideaki Shirasaki et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Co-operative signalling through DP1 and DP2 prostanoid receptors is required to enhance leukotriene C4 synthesis induced by prostaglandin D2 in eosinophils

(2010) FP Mesquita-Santos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced airway smooth muscle cell thromboxane receptor signaling via activation of JNK MAPK and extracellular calcium influx

(2010) Ying Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endothelium-derived prostaglandin I2 controls the migration of eosinophils

(2010) Viktoria Konya et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammation

(2009) S. Aggarwal et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Expression and Characterization of PGD2 Receptors in Chronic Rhinosinusitis: Modulation of DP and CRTH2 by PGD2

(2008) Miki Yamamoto et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY